Tyrosine kinase signaling in and on the endoplasmic reticulum

Farhan, Hesso

doi:10.1042/bst20190543

Cited by 9 publications

(5 citation statements)

References 47 publications

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“…These included ER and endosomal signals, which may suggest RTKs to localize in some extent to various membrane compartments. Endosomal and ER localization may be due to both physiological activity (identified for many RTKs; for reviews, see Miaczynska, 2013 ; Fraser et al , 2017 ; and Farhan, 2020 ) and some unspecific antibody staining.…”

Section: Resultsmentioning

confidence: 99%

Physical and functional interactome atlas of human receptor tyrosine kinases

et al. 2022

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Much cell‐to‐cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles of RTKs. We use affinity purification coupled to mass spectrometry (AP‐MS) to characterize stable binding partners and RTK–protein complexes, proximity‐dependent biotin identification (BioID) to identify transient and proximal interactions, and an in vitro kinase assay to identify RTK substrates. To identify how kinase interactions depend on kinase activity, we also use kinase‐deficient mutants. Our data represent a comprehensive, systemic mapping of RTK interactions and substrates. This resource adds information regarding well‐studied RTKs, offers insights into the functions of less well‐studied RTKs, and highlights RTK‐RTK interactions and shared signaling pathways.

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Section: Resultsmentioning

confidence: 99%

Physical and functional interactome atlas of human receptor tyrosine kinases

et al. 2022

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“…PKDCC regulates the transport of ERP29, RP44, BiP, and PDIA3 by phosphorylating transport receptors. These proteins are components of ER proteostasis and play an important role in UPR-induced apoptosis ( 44 ). Therefore, FAM20C, FAM198A, and PKDCC are essential in regulating ER proteostasis and UPR signaling.…”

Section: Physiological Processes and Pathological Results Of The Secr...mentioning

confidence: 99%

Regulation of secretory pathway kinase or kinase-like proteins in human cancers

Zhu²,

Ren³

et al. 2023

Front. Immunol.

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Secretory pathway kinase or kinase-like proteins (SPKKPs) are effective in the lumen of the endoplasmic reticulum (ER), Golgi apparatus (GA), and extracellular space. These proteins are involved in secretory signaling pathways and are distinctive from typical protein kinases. Various reports have shown that SPKKPs regulate the tumorigenesis and progression of human cancer via the phosphorylation of various substrates, which is essential in physiological and pathological processes. Emerging evidence has revealed that the expression of SPKKPs in human cancers is regulated by multiple factors. This review summarizes the current understanding of the contribution of SPKKPs in tumorigenesis and the progression of immunity. With the epidemic trend of immunotherapy, targeting SPKKPs may be a novel approach to anticancer therapy. This study briefly discusses the recent advances regarding SPKKPs.

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“…These included ER and endosomal signals, which may suggest RTKs to localize in some extent to various membrane compartments. Endosomal and ER localization may be due to both physiological activity (identified for many RTKs; for reviews, see Miaczynska, 2013;Fraser et al, 2017;and Farhan, 2020) and some unspecific antibody staining.…”

Section: Defining the Rtk Interaction Landscapementioning

confidence: 99%