Tyrosine kinase inhibitors versus radiation therapy in unresectable dermatofibrosarcoma protuberans (DFSP): A narrative systematic review

Henry, Owen S.; Platoff, Rebecca; Cerniglia, Katherine S.; Batchu, Sai; Goodwin, Brandon; Sandilos, Georgianna; Adams, Amanda A.; Hong, Young Kwon

doi:10.1016/j.amjsurg.2022.09.040

Cited by 4 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, radiation after surgery can cause skin flap necrosis, edema, and delayed healing in the resection site. Hence, the choice of radiotherapy is highly dependent on the patients' conditions [9,13]. Some studies have suggested the use of traditional post-op radiotherapy since DFSP is known to be radiosensitive.…”

Section: Nonsurgical Treatmentmentioning

confidence: 99%

“…However, due to various CD34 immunoreactivity in DFSP, its presentation can be mistaken with other malignancies or even benign lesions [4][5][6][7]. The majority of DFSP cases have a t (17; 22) (q22; q13) which results in the creation of COL1A1-PDGFB fusion transcripts [8][9][10][11]. Although it has low metastasis risk, it has significant destructive effects locally, which is mostly diagnosed in lesions of the trunk area and distal part of the extremities [12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

et al. 2023

View full text Add to dashboard Cite

Background Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary stages, it can cause a high burden of morbidity unless it is thoroughly excised. Case presentation Here, we review six cases of DFSP which were characterized by skin lesions in various parts of the body. Patients were from 26 to 51 years old; four were Asian men and two were Asian women. Wide surgical excision was performed for all these patients and no extra treatment was considered. Samples were studied by hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) tests. Only one of our patients experienced recurrence after the initial surgery. Conclusion Determining the best surgical method is still a dilemma in the treatment of DFSP lesions. There are numerous studies to prove the efficacy of various surgical interventions. Although DFSP is not commonly known as a malignant skin lesion, delay in treatment will have a catastrophic impact on patients’ lives. Thus, applying an in-time surgical method (wide local excision in our cases) in treating DFSP is crucial in preventing recurrence as well as decreasing the morbidity burden of DFSP.

show abstract

Section: Nonsurgical Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Pazopanib, a VEGF receptor inhibitor, has been approved for the treatment of nonadipocytic STS [71] . In a phase 3 RCT, pazopanib showed significant improvement in progression-free survival in non-adipocytic STS; however, overall survival was not different between treatments [76] . Other target therapies are useful in certain STS histologic subtypes.…”

Section: Targeted Therapymentioning

confidence: 93%

Management of oligometastatic disease in soft tissue sarcomas

Gonzalez¹

2023

J Cancer Metastasis Treat

View full text Add to dashboard Cite

Oligometastatic soft tissue sarcoma represents an intermediate state between localized and disseminated disease. Combination A combination of surgery, radiotherapy and systemic treatment significantly improves prognosis, with a 5-year overall survival as high as 50%. Due to the high prevalence of lung metastases, most of the surgical evidence is centered around lung metastasectomy. The decision to perform surgical metastasectomy remains dependent on optimal patient selection. Adequate post-surgical lung function, absence of extrapulmonary metastases, control of the primary tumor, and feasibility of achieving negative margins are major criteria for patients to undergo successful surgery. Adequate margins, longer disease-free interval, unilateral, limited number (≤ 2), metachronous and small (< 2 cm) pulmonary metastasis are some factors associated with improved survival. Radiotherapy, especially SBRT, is an effective treatment for disease control, and its use as (neo)-adjuvant therapy has shown promising results. However, studies comparing radiotherapy against surgery are missing and the efficacy of radiotherapy independent of surgery is not yet clear. Interventional radiology techniques such as percutaneous thermal ablation (PTA) or arterial embolization have also been described as potential treatment alternatives in candidates deemed not fit for surgery. Systemic treatment has traditionally consisted of an anthracycline (doxorubicin)-based regimen with the addition of ifosfamide in certain cases. Recent advances in systemic treatment include the use of targeted therapy and immunotherapy in (oligo)-metastatic STS. However, except for certain histologies, most STS subtypes are chemoresistant, and the response to systemic treatment is poor.

show abstract

Molekularpathologie bei ausgewählten Weichgewebssarkomen: diagnostisch und therapeutisch relevante Aberrationen

Wardelmann

Hartmann

2022

Onkologie

View full text Add to dashboard Cite

Tyrosine kinase inhibitors versus radiation therapy in unresectable dermatofibrosarcoma protuberans (DFSP): A narrative systematic review

Cited by 4 publications

References 29 publications

Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

Management of oligometastatic disease in soft tissue sarcomas

Molekularpathologie bei ausgewählten Weichgewebssarkomen: diagnostisch und therapeutisch relevante Aberrationen

Contact Info

Product

Resources

About