Tyrosine hydroxylase activity in the heart of the cardiomyopathic Syrian hamster

Sole, Michael J.; Wurtman, Richard J.; Lo, C.-M.; Kamble, Arvind B.; Sonnenblick, Edmund H.

doi:10.1016/0022-2828(77)90031-1

Cited by 19 publications

(1 citation statement)

References 12 publications

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“…Available evidence suggests in addition that the cardiomyopathic hamster heart is subjected to increased sympathetic activity since norepinephrine synthesis and turnover is increased during the myolytic and hypertrophic stages of the disease (Sole et al, 1977). Norepinephrine concentration also increases concomitantly with the development of necrosis (Angelakos et Pasternac et al MAY 1982-201 THE CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES al, 1973Angelakos et al, 1972).…”

Section: Relationship Between Increased Plasma Catecholamines and Lefmentioning

confidence: 99%

Increased Plasma Catecholamines in Patients with Friedreich’s Ataxia

Pasternac

Wagniart

Olivenstein

et al. 1982

Can. j. neurol. sci.

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SUMMARY:We studied free plasma catecholamines in 23 patients with Friedreich’s ataxia, having a mean age of 22 ± 9.6 (SD) years. Conjugated catecholamines were also studied in 10 patients. Mean plasma norepinephrine and epinephrine were significantly higher than controls both in the supine and standing positions. In total 15 out of 23 patients (65%) had increased free and/or conjugated plasma catecholamines. The increase in plasma catecholamines was more marked in patients with severe neuromotor impairment. Among the patients with left ventricular concentric hypertrophy (wall thickness >12 mm), only 3 had no demonstrable sympathetic hyperfunction.Since the high local concentrations of norepinephrine at the site of release from sympathetic nerve terminals may serve as a trigger for the hypertrophic response of the myocardial cell, it is suggested that early pharmacological intervention could prevent or limit the cardiomyopathic process or its clinical consequences.

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Section: Relationship Between Increased Plasma Catecholamines and Lefmentioning

confidence: 99%