Tyrosine Hydroxylase Activity and Catecholamine Content in the Adrenals of Young Hypo- and Hyperthyroid Rats

Gripois, D.; Klein, C.; Valens, M.

doi:10.1159/000241269

Cited by 18 publications

(3 citation statements)

References 9 publications

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“…It may be suggested that the increase in adrenal DA content is the consequence of tyrosine hydroxylase activation (Almgren et al, 1979; Snider and Kuchel, 1983). This suggestion was supported by the findings of other investigators who reported that the adrenal content of catecholamine and the activity of tyrosine hydroxylase and dopamine‐β‐hydroxylase, two enzymes involved in catecholamine biosynthesis, are modulated by the thyroid hormones (Gripois et al, 1980; Gripois and Valens, 1983).…”

Section: Discussionsupporting

confidence: 70%

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Hassan

Rahman

Aly

et al. 2013

Intl J of Devlp Neuroscience

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The present study was conducted to investigate the effect of experimentally-induced hyperthyroidism on dopamine (DA), norepinephrine (NE) and serotonin (5-HT) levels in different brain regions as well as in blood plasma, cardiac muscle and adrenal gland of young and adult male albino rats (60 rats of each age). Hyperthyroidism was induced by daily s.c. injection of L-thyroxine (L-T4, 500 μg/kg body wt.) for 21 consecutive days. Induction of hyperthyroidism caused a significant elevation in DA and 5-HT levels in most of the tissues studied of both young and adult animals after 7, 14, and 21 days. NE content significantly decreased after 21 days in most of the brain regions examined and after 14 and 21 days in blood plasma of young rats following hyperthyroidism. In adult rats, NE content decreased after 14 and 21 days in cardiac muscle and after 21 days only in adrenal gland. It may be suggested that the changes in monoamines level induced by hyperthyroidism may be due to disturbance in the synthesis, turnover and release of these amines through the neurons impairment or may attributed to an alteration pattern of their synthesis and/or degradative enzymes or changes in the sensitivity of their receptors.

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Section: Discussionsupporting

confidence: 70%

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Hassan

Rahman

Aly

et al. 2013

Intl J of Devlp Neuroscience

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show abstract

“…These are the conditions we chose for the incubation in the present study. Even in these conditions, which do not correspond to the optimal functioning of the enzyme, the basal levels of tyrosine hydroxylase (as represented by the values for the saline-injected pups) are increased by neonatal hypothyroidism, just as they are when tyrosine hydroxylase is assayed under more optimal conditions (Gripois et al 1980;Lau & Slotkin 1982).…”

Section: Discussionmentioning

confidence: 99%

Influence of Neonatal Hypothyroidism on Adrenal Tyrosine Hydroxylase Activation in the Young Rat

Valens

Gripois

1990

Clin Exp Pharma Physio

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“…Thus, in the young rat, PNMT is modulated by hypo-and hyperthyroidism with TH and DBH [7,8,13,14] but to a lesser extent.…”

Section: Discussionmentioning

confidence: 99%

Adrenal Phenylethanolamine-N-Methyltransferase Activity in the Young Rat: Influence of Thyroid Hormones and Insulin-Induced Hypoglycemia

Gripois¹,

Valens²

1986

Neonatology

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The postnatal evolution of adrenal phenylethanolamine-N-methyltransferase (PNMT) activity is slightly accelerated by hypothyroidism and slowed by hyperthyroidism. In 14-day-old rats a single stimulation of the adrenals by insulin-induced hypoglycemia does not lead to any change in enzymatic activity. If the stimulation is repeated for 4 days, it leads to a net increase in adrenal PNMT activity in the control rats, while no increase occurs in hypo- or hyperthyroid animals.

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Tyrosine Hydroxylase Activity and Catecholamine Content in the Adrenals of Young Hypo- and Hyperthyroid Rats

Cited by 18 publications

References 9 publications

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Alterations in monoamines level in discrete brain regions and other peripheral tissues in young and adult male rats during experimental hyperthyroidism

Influence of Neonatal Hypothyroidism on Adrenal Tyrosine Hydroxylase Activation in the Young Rat

Adrenal Phenylethanolamine-N-Methyltransferase Activity in the Young Rat: Influence of Thyroid Hormones and Insulin-Induced Hypoglycemia

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