Tyrosine crystals in salivary gland tumours.

Friedmann, I.; Spilg, W. G. S.; Russell, TL

doi:10.1136/jcp.35.1.120-a

Cited by 7 publications

(2 citation statements)

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“…In addition, there have been occasional reports describing tyrosine crystals in these tumors (Bullock 1953, Nochomovitz & Kahn 1974, Thackray & Lucas 1974, Thomas & Hutt 1981. Similar crystals have been observed in a ceruminous gland tumour (Friedmann et al 1982). The histological investigation of the crystals in the parotid tumours has been somewhat limited.…”

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confidence: 91%

Tyrosine‐rich crystals in pleomorphic adenomas of parotid glands

Chaplin

Darke

Patel

1983

J Oral Pathology Medicine

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confidence: 91%

Tyrosine‐rich crystals in pleomorphic adenomas of parotid glands

Chaplin

Darke

Patel

1983

J Oral Pathology Medicine

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“…Tyrosine crystals have also been described in association with numerous kinds of tumors but particularly those of the parotid glands − and the salivary glands. − This is noteworthy because those glands also generate digestive enzymes similar to those produced by the pancreas. Thus the proteolytic process that we employed to obtain the crystals may parallel natural processes that occur in some living tissues.…”

Section: Discussionmentioning

confidence: 99%

Tyrosine Microcrystals Produced by Digestion of Proteins with Pancreatic Enzymes

McPherson

Larson

Kuznetsov

2012

Crystal Growth & Design

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If serum albumin from several animals, including humans, at concentrations greater than about 60 mg/mL is combined with an aqueous extract of porcine or human pancreas, then massive amounts of microcrystals develop. Both raw blood serum, as well as a range of concentrated, pure proteins, when combined with the extract produced identical crystals. Morphologies of crystals and their aggregates did, however, show some dependence on the starting protein material. Crystals could be dissolved by boiling in water and recrystallized. By X-ray diffraction we showed the crystals to be l-tyrosine crystals, presumably a degradation product of the starting proteins. Amino acid analysis, supported by mass spectrometry, of even well washed crystals, however, consistently showed them to be composed of 20% to 30% of other amino acids. An atomic force microscopy investigation of the crystals revealed that the crystal surfaces were persistently coated with spherical particles about 3 nm in diameter. The particles are apparently micellar arrangements of oligopeptides. Some implications of our results with regard the appearance of tyrosine crystals in human tissues under pathological conditions, in tumors, and in natural products such as foods are discussed.

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