Tyrosinase Inhibitory Effects of Sargachromanol G, Sargachromanol I and Mojabanchromanol b isolated from Myagropsis myagroides

Abstract

Kim et al.: Tyrosinase Inhibitory Effects of Chromenes from Myagropsis myagroidesThe aim of this study was to elucidate the effect of Myagropsis myagroides extract on tyrosinase activity. Inhibition of tyrosinase was observed in the presence of an n-hexane fraction of Myagropsis myagroides. Separation of the n-hexane fraction using silica gel column chromatography yielded the chloroform:methanol (50:1) fraction, which showed the highest tyrosinase inhibitory activity. After several separation and purification steps, sargachromanol G, sargachromanol I, and mojabanchromanol b were obtained. These 3 chromene compounds displayed strong tyrosinase inhibitory activity. It could be concluded that Myagropsis myagroides is a potential source of natural antimelagenic compounds.

Seaweed-Based Molecules and Their Potential Biological Activities: An Eco-Sustainable Cosmetics

“…Many brown seaweed species, including Laminaria sp., Saccharina sp., Ascophyllum sp., Fucus sp., Sargassum sp., and Undaria sp., are well-known for laminaran properties, such as antitumor, anti-inflammatory, antiviral, antioxidant, anticoagulant, and anti-cellulite properties [ 147 , 148 , 149 ]. Among all, sulfated polysaccharides have attractive considerable attention in cosmeceutical activities: UV protector, anti-inflammatory, anticoagulant antithrombotic, tyrosinase inhibitor, antitumoral, antibacterial, antidiabetic, and antioxidative [ 150 , 151 , 152 , 153 ]. Moon et al [ 154 ] found the role of fucoidan in an inhibition of matrix metalloproteinase induced by UVB radiation.…”

Cosmeceutical Significance of Seaweed: A Focus on Carbohydrates and Peptides in Skin Applications

“…According to Senni et al [146], fucoidan shows promise in preventing photoaging of the skin. Additionally, it acts as a tyrosinase inhibitor, reducing skin pigmentation when utilized in skin-whitening formulations [147,148]. Ulvan, as suggested by Carvalho and Pereira [149], is considered a desirable raw material for cosmeceuticals due to its beneficial moisturizing, protective, antitumor, and antioxidative properties, particularly in gel formu-lations [150,151].…”

Ligularia fischeri ethanol extract: An inhibitor of alpha‐melanocyte‐stimulating hormone‐stimulated melanogenesis in B16F10 melanoma cells

“…5 Tyrosinase is a rate-limiting enzyme that plays an important role as the first step in generating melanin, and the development of various tyrosinase inhibitors to suppress the generation of excessive melanin is being actively pursued. 6 In addition, microphthalmia-associated transcription factor (MITF) expression is controlled by phosphorylation of mitogenactivated protein kinase, and mitotic signals leading to intensive and continuous activation of extracellular signal-regulated kinase (ERK) reduce MITF protein levels. 7,8 Therefore, interest in skin whitening is continuously increasing, not only in terms of skin health but also in terms of beauty, and research on the development of skin whitening agents is being actively pursued.…”

“…Using tyrosine as a substrate, it is converted to DOPA‐quinone by tyrosinase, tyrosinase‐related protein (TRP)‐1, and TRP‐2, and then synthesized into melanin 5 . Tyrosinase is a rate‐limiting enzyme that plays an important role as the first step in generating melanin, and the development of various tyrosinase inhibitors to suppress the generation of excessive melanin is being actively pursued 6 …”