Tyrosinase Inhibition and Antimelanogenic Effects of Resorcinol‐Containing Compounds
Morane Beaumet,
Leticia M. Lazinski,
Marc Maresca
et al.
Abstract:Tyrosinases (TYRs) are copper‐containing metalloenzymes present in a large diversity of species. In human, hTYR is responsible for pivotal steps in melanogenesis, catalysing the oxidation of l‐tyrosine to l‐DOPA and further to dopaquinone. While numerous TYR inhibitors have been reported, polyphenolic compounds tend to dominate the literature. However, many of these compounds, particularly monophenols and catechols, have been identified as alternative substrates rather than true inhibitors, given their structu… Show more
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