2021
DOI: 10.1016/j.foodchem.2020.127948
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Tyrosinase/caffeic acid cross-linking alleviated shrimp (Metapenaeus ensis) tropomyosin-induced allergic responses by modulating the Th1/Th2 immunobalance

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Cited by 20 publications
(11 citation statements)
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“…Enzymatic treatments can further improve the digestibility of TM and dramatically reduce the recognitions of IgG/IgE of the digested crosslinked TM samples. The secretions of cytokines and mediators from KU812 and RBL-2H3 cells could be significantly inhibited upon stimulation with crosslinked TM, thereby revealing the abridged stimulation abilities upon enzymatic crosslinking (Ahmed et al, 2020(Ahmed et al, , 2021.…”
Section: Shellfish Allergymentioning
confidence: 95%
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“…Enzymatic treatments can further improve the digestibility of TM and dramatically reduce the recognitions of IgG/IgE of the digested crosslinked TM samples. The secretions of cytokines and mediators from KU812 and RBL-2H3 cells could be significantly inhibited upon stimulation with crosslinked TM, thereby revealing the abridged stimulation abilities upon enzymatic crosslinking (Ahmed et al, 2020(Ahmed et al, , 2021.…”
Section: Shellfish Allergymentioning
confidence: 95%
“…Enzyme to substrate ratio and reaction conditions such as temperature, time, and pH are imperative factors in obtaining maximum polymerization of allergenic proteins. The addition of small phenolic mediators in combination with oxidative enzymes has shown higher efficacy to improve the crosslinking ability of enzymes by providing additional functional groups and reactive sites (Ahmed et al, 2021;Heck et al, 2013;Isaschar-Ovdat & Fishman, 2018). Figure 2 presents the proposed underlying mechanism of crosslinking of food allergens catalyzed by crosslinking enzymes in the presence and absence of phenolic mediators.…”
Section: Application Of Crosslinking Enzymes For Alleviating Food Allergenicitymentioning
confidence: 99%
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