Typing of Leucocyte Antigens in Man

Govallo, V. I.; Belotsky, Sandro; Trius, E. B.; Grygorieva, Maria P.

doi:10.1159/000427390

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“…The promoting effect of parenterally administered surfagon o n PHA and PHA with surfagon, injected intradermally, was probably a sign of disregulation in animals' reproductive system (e.g., repeatedly inseminated cows with infertility of uncertain etiology), thus explaining the paradoxical effect. Slight diminished T-cell activity in pregnant and lactating cows vs. nonpregnant ones corresponds with other studies (Govallo, 1987;Skopets and Skopets, 1988). while the increase in skin macrophage and B-cell activity associated with pregnant vs. nonpregnant cows disagrees with other findings (Govallo, 1987).…”

Section: Discussionsupporting

confidence: 90%

“…Slight diminished T-cell activity in pregnant and lactating cows vs. nonpregnant ones corresponds with other studies (Govallo, 1987;Skopets and Skopets, 1988). while the increase in skin macrophage and B-cell activity associated with pregnant vs. nonpregnant cows disagrees with other findings (Govallo, 1987). Higher activity of macrophages and B-lymphocytes in pregnant cows vs. nonpregnant ones may be causes by the fact that in terms of homeostasis, a decrease of the activity of one component (in this case 'I-cells) might lead t o higher activity of others (B-cell and macrophages).…”

Section: Discussionsupporting

confidence: 90%

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Effect of Biologically Active Substances Controlling Bovine Reproduction on T-Lymphocyte and Macrophage Activity

Veksler¹,

Skopets²,

Skopets³

1992

Reprod Domest Anim

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Contents: In a series of experiments with various patterns of intradermal tests, relationships of oxytocin, estrophan (a synthetic analogue of PGF2α), surfagon (a synthetic analogue of gonadotropin‐releasing hormone), bull semen extract, seminal plasma, CaCl2, Vitamin A, carotene, cortisol and bovine skin lymphocytes and macrophage activity were studied. Skin T‐lymphocyte activation was obtained by means of an intradermal injection of the mitogen, phytohemagglutinin (PHA), while that of macrophages and B‐cells, was induced by lipopolysaccharide (LPS) of Gram‐negative bacilli. It has been estabished that Ca2+ ions stimulated skin T‐cells and oxytocin controlled skin immunocyte activity. Bovine seminal plasma inhibited activity of skin T‐lymphocytes, macrophages and skin B‐lymphocytes while bovine semen extract influenced only skin macrophages and B‐lymphocytes. Skin T‐cell activity was slightly suppressed (by 26.4%) in pregnant lactating cows as compared with postpartum ones. Macrophage and B‐cell activity was increased (P < 0.05) in comparison with the period of 2 to 10 days after calving. A positive correlation was revealed between vitamin A content in blood and skin T‐lymphocyte activity (r =+0.33), vitamin A content in blood and macrophage and B‐lymphocyte activity (r =+ 0.41), carotene content in blood and skin T‐lymphocyte activity (r =+ 29) and carotene content in blood and skin macrophage and B‐lymphocyte activity (r =+42). The correlation between blood cortisol and macrophage and B‐lymphocyte activity was negative (r =−0.35). Inhalt: Einfluß biologisch aktiver Substanzen auf T‐Lymphozyten und Makrophagen‐aktivität im Hinblick auf die Steuerung des Reproduktionsverhaltens beim Rind In einer Reihe von Experimenten wurde anhand verschiedener Intradermal‐Tests die Abhangigkeit von Oxytocin, Estrophan (einem synthetischen PGF2α Analog), Surfagon (einem synthetischen Gonadotropin‐Releasing Hormon), Bullenspermaextrakt, Seminal‐plasma, Call2, Vitamin A, Carotin, Kortisol zu der Aktivität von Rinderhaut Lymphozyten und Makrophagen untersucht. Die Haut‐T‐Lymphozytenaktivierung wurde durch intradermale Injektionen des Mitogens Phytohämagglutinin (PHA) erreicht, während Makrophagen und B‐Lymphozyten durch Lipopoly Saccharide (LPS) Gram‐negative Bakterien induziert wurde. Es konnte gezeigt werden, daß Kalziumionen die T‐Zellen aktivieren und Oxytocin die Immunozyten der Haut stimulieren. Seminalplasma schränkte die Aktivität der T‐ und B‐Lymphozyten in der Haut ein. Dagegen beeinflußte das Spermaextrakt nur die Makrophagen und B‐Lymphozyten. Die Aktivität der T‐Zellen wurde geringgradig (26,4%) bei tragenden, laktierenden Kühen im Vergleich zu Post‐partum Tieren unterdrückt. Die Aktivität der Makrophagen und der B‐Lymphozyten stieg dagegen im Vergleich zu der Periode nach dem Abkalben (Tag 2–10) an (p < 0,05). Eine positive Korrelation bestand zwischen dem Vitamin A‐Gehalt im Blut zu der T‐Lymphozytenaktivität in der Haut (r =+ 0,33) und der Makrophagen und B‐Lymphozytenaktivität (r =+ 0,41). Zwischen Karotingehalt...

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%