Typing of escherichia coli O and K antigens in patients with urinary tract infections

Abstract

In a long-term investigation in children and adult patients with urinary tract infection, 1403 Escherichia coli strains were serotyped and 266 strains were subjected to serological investigation. The most frequently occurring O groups were O6, O8, O2, O18, O4, O75, O1, O22, O7 and O9. L type antigens were predominant among the K antigens. Infants in whom pyelonephritis manifested itself for the first time exhibited an above average rate of infection with O2, O4 and O75. A reinfection rate of 84 to 91% was observed in children in follow-up investigations.

Escherichia coliin extra-intestinal infections

“…0 antigens E. coli strains of a relative small number of 0 groups, namely 0 1, 02, 04, 06, 0 7, 0 18 and 0 75, have been reported to account for a major part of 0-groupable UTI strains from different parts of the world (Ranz, 1962;Turck, Petersdorf & Furnier, 1962;Kunin, Deutscher & Paquin, 1964;Vosti et al 1964;McGeachie, 1965;0rskov & 0rskov, 1967;Griineberg, Leigh & Brumfitt, 1968). It has also been demonstrated that strains from the first infection showed a greater concentration of these 0 groups compared with strains from recurrent infections (McGeachie, 1965: Bergstrom et al 19670rskov & 0rskov, 1967;Mabeck, 0rskov & 0rskov, 1971 b;Sietzen, 1979). When UTIs were diagnosed as ABU, cystitis or pyelonephritis, it was furthermore demonstrated that strains of the above-mentioned 0 groups with the addition of 0 16 were found in 800 of pyelonephritis, in -590 of cystitis and in 31 00 of ABU strains (Lindberg et al 1975a).…”

Correlation between uropathogenic properties ofEscherichia colifrom urinary tract infections and the antibody-coated bacteria test and comparison with faecal strains

“…This is partly because there is significant geographical variation amongst E. coli from urinary tract infections (Griuneberg & Bettelheim, 1969;Sietzen, 1979). In addition, little information is available for New Zealand strains, as studies have been carried out with only limited sets of antisera (Peddie & Little, 1978).…”

Cloned hemolysin genes from Escherichia coli that cause urinary tract infection determine different levels of toxicity in mice

“…Among E. coli strains causing UTI, the production of hemolysin is often associated with other factors assumed to contribute to virulence, i.e., mannose-resistant hemagglutination (Mrh+) caused by specific protein pili (7) and specific 0and K-antigens (14,27,28). These additional factors cause adherence of the bacteria to epithelial cells and resistance to serum and phagocytosis (20,31,32).…”