Typing of Bact. coli

Wright, Joyce

doi:10.1136/bmj.2.4676.460

Cited by 7 publications

(12 citation statements)

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“…In general, the results of these studies showed that heparin has no effect on platelet adhesiveness in vitro or in normal subjects except in high concentrations, and that its effect in patients with ischaemic heart disease is uncertain. However, these results do not necessarily apply to the situation after operation when there is an acute increase in platelet adhesiveness (Wright, 1942;Moolten, Vroman, and Vroman, 1949;Ham and Slack, 1967).…”

mentioning

confidence: 90%

The effect of small doses of heparin on platelet adhesiveness and lipoprotein-lipase activity before and after operation

Ham

Slack

1968

Journal of British Surgery

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confidence: 90%

The effect of small doses of heparin on platelet adhesiveness and lipoprotein-lipase activity before and after operation

Ham

Slack

1968

Journal of British Surgery

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“…the dog, was followed by an even more rapid disappearance and permanent elimination of the microorganisms as shown by our results and those of others (17). Rabbits immunized actively against pneumococci reacted in essentially the same manner as the dog and exhibited pneumococcidal activity in the blood (15).…”

Section: Discussionmentioning

confidence: 83%

“…This is true for both virulent and avirulent bacteria and for naturally resistant and susceptible animals. Observations on pneumococcemia in the rabbit (15,15,18,19), an animal which exhibits very little natural resistance to infection with virulent strains of pneumococci and lacks blood bactericidal power, have demonstrated that these microorganisms injected intravenously, in quantities greatly in in excess of the lethal dose, were removed quickly and almost completely from the circulating blood. Such restraint of bacteremia was only temporary, however, since the rabbits thus treated always died of an overwhelming pneumococcemia.…”

Section: Discussionmentioning

confidence: 99%

On the Nature of Bacteremia in Experimental Pneumococcal Pneumonia in the Dog

Gregg

Robertson

1953

Journal of Experimental Medicine

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In the preceding study of the relationship of the natural pneumococcidalpromoting activity of the serum to bacteremia in dogs with experimental pneumococcal pneumonia (1), it was found that the blood of non-bacteremic dogs retains its natural humoral immunity with a remarkable degree of constancy. The occurrence of bacteremia was followed by wide individual variations in the concentration of these antipneumococcal properties, ranging from complete disappearance in the presence of relatively few circulating pneumococci to their persistence in blood containing great numbers of microorganisms. These fluctuations were interpreted to signify differences in the body's capacity to elaborate new antibodies in response to the continued escape of pneumococci from the pulmonary lesion. That the observed variation in pneumococcal immune substances represented corresponding degrees of pneumococcidal power of the blood seemed evident from our tests performed with the shed blood; but to what degrees this action of the blood in vitro reflects the ability of the body to deal with pneumococci in the circulation, our observations failed to elucidate, nor did they provide any data as to whether the pneumococcusclearing action of the blood is more or less effective in the diseased animal than in the normal one.It was felt that a profitable approach to these questions could be made by observing the effects of artificially induced pneumococcemia in normal and diseased (pneumonic) animals and that such information would contribute to the solution of certain other fundamental problems presented by the bacteremic state, such as the rate of escape of pneumococci from pulmonary lesions, the capacity of the blood stream to dispose of them, and the mechanism by which the body controls the degree of blood invasion in the absence of demonstrable humoral immunity.

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“…The nature of platelet adhesion is at present unknown. It was supposed by some authors (Lenggenhager, 1936;Wright, 1946) to be the result, rather than the cause, of coagulation, being due to a film of fibrin forming on the platelet surface. The demonstration of platelet adhesion by Pinniger and Prunty (1946) in the blood of a case of congenital total absence of fibrinogen appears to dispose of this explanation.…”

Section: Hcreditarymentioning

confidence: 99%

Normal and Abnormal Blood Coagulation: A Review

Macfarlane¹

1948

J Clin Pathol

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IntroductionAs one of the lesser problems of physiology, the nature of blood coagulation has received more than its share of investigation. There is now an insurmountable mass of literature dealing with its various aspects, contributed over the greater part of a century by some of the foremost experimentalists of their time, and embodying theories, even whole schools-of thought, that have produced little but acrimony and confusion. The reasons for this activity are not at once apparent, though no doubt there is something provocative to the curious mind in the spontaneous conversion of fluid blood to solid clot. More attractive, perhaps, is the ease with which experiments in blood coagulation can be devised and carried out. The requirements for such work in technique, apparatus, and even in time are seemingly not exacting. The real or imaginary components of a theoretical mechanism can be separated to the investigator's satisfaction with little difficulty and allowed to interact in endless permutations and combinations. Each experiment suggests another; always the intangible solution seems just within reach and the experimenter is led deeper and deeper into his own, often unjustified, interpretations of his findings. Thus it is that elaborate theories have grown up which, aided by the confusion of rival terminologies, have so obscured-and entangled basic facts that these are now scarcely recognizable.Within the last decade this hitherto rather academic problem has taken on a more practical aspect; the discovery of vitamin K and the use of anticoagulants to reduce the danger of post-operative thrombosis, both advances of fundamental importance, have demanded the reliable quantitative assay of coagulation factors. This development has necessarily clarified

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Typing of Bact. coli

Cited by 7 publications

References 0 publications

The effect of small doses of heparin on platelet adhesiveness and lipoprotein-lipase activity before and after operation

The effect of small doses of heparin on platelet adhesiveness and lipoprotein-lipase activity before and after operation

On the Nature of Bacteremia in Experimental Pneumococcal Pneumonia in the Dog

Normal and Abnormal Blood Coagulation: A Review

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