Typical dietary habits and elevated intestinal permeability in people with excess body weight and IBS

Fedorin, M. M.; Гаус, О. В.; Ливзан, М. А.; Sukhanova, S. A.

doi:10.31146/1682-8658-ecg-190-6-50-56

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…В условиях пандемии ожирения особый интерес для изучения особенностей течения СРК и механизмов формирования симптомов представляет когорта больных СРК, страдающих избыточной массой тела и ожирением [2,3].…”

Section: актуальностьunclassified

Features of the course of irritable bowel syndrome in overweight and obese people

Fedorin,

Livzan,

Gaus

2024

jour

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The aim of the study: to study the characteristics of the course of irritable bowel syndrome (IBS), associated with overweight and obesity, to optimize the management of this group of patients. Material and methods. An open-label cross-sectional study was performed including 175 participants aged 18 to 44 years (mean age 30.06 ± 6.15 years). Group 1 included 100 patients with IBS aged 18 to 44 years (mean age 30.63 ± 6.37 years, BMI 25.88 ± 6.28 kg/m2). In group 1, subgroup 1A included 50 people with IBS associated with overweight or obesity. Subgroup 1B included 50 IBS patients with normal weight. Group 2 included 75 people who did not suffer from IBS, aged from 19 to 43 years (mean age 29.31 ± 5.81 years, BMI 27.80 ± 6.20 kg/m2). Subgroup 2A included 50 participants who did not suffer from IBS and were overweight or obese. Subgroup 2B included 25 apparently healthy participants. The presence and severity of IBS symptoms were assessed using a 10-point scale. The severity of gastrointestinal symptoms, the presence of anxiety and depression, the level of specific anxiety, quality of life and eating habits were assessed using verified questionnaires. All participants underwent a study of the levels of leptin and adiponectin in the blood serum and zonulin in the feces. Results. The characteristic clinical stigmas in patients suffering from IBS associated with overweight and obesity are described: IBS with a predominance of constipation, severe course of the disease, high incidence of signs of depressive and anxiety disorders, special eating habits characterized by the predominance of flour, sweet, fatty and salty foods in the diet food, severe disturbances in the permeability of the intestinal epithelial barrier. High concentrations of leptin and low levels of adiponectin in the blood serum of such patients may play a significant role in the formation of IBS symptoms. Conclusion. The results obtained open up opportunities for research into the pathogenetic mechanisms of the formation of IBS in people with overweight and obesity, as well as modification of existing treatment regimens for patients with IBS.

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Section: актуальностьunclassified

Features of the course of irritable bowel syndrome in overweight and obese people

Fedorin,

Livzan,

Gaus

2024

jour

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Atrial fibrillation and the gut microbiota: is there a link?

Zor’kina¹,

Skirdenko²,

Gorbenko³

et al. 2022

Profil. med.

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Potential role of short-chain fatty acids in irritable bowel syndrome in overweight and obese individuals

Fedorin,

Livzan,

Gaus

et al. 2024

Medicinskij sovet

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Due to increasing prevalence of functional diseases of the colon in obese patients, the mechanisms by which the intestinal microbiota affects the development of symptoms of irritable bowel syndrome (IBS) in the setting of metabolic activity of adipose tissue should be investigated. The quantitative and qualitative changes in the pool of synthesized short-chain fatty acids, which have a multidirectional impact on the colonic motility is one of the key mechanisms by which the intestinal microbiota affects the occurrence and features of the course of irritable bowel syndrome. But as regards the issue of whether individual short-chain fatty acids have an impact on the severity of abdominal pain and characteristics of colonic motility dysfunction, it remains a subject of discussions. The study of the mechanisms of impact of short-chain fatty acids on the development and progression of obesity deserves special attention. Increased serum and faecal short-chain fatty acid levels in obese patients can either be a result of changes in the intestinal microflora composition associated with special eating habits and lifestyle, or have an independent effect on the development of obesity in individuals due to intestinal microflora composition disorders that have been already developed. Due to special features of the course of irritable bowel syndrome associated with overweight and obesity, studying the intestinal microbiota composition and the short-chain fatty acids produced by it in this cohort of IBS patients is of particular interest. This publication has been prepared to describe and systematize the possible mechanisms of impact of short-chain fatty acids on the development of abdominal pain and impaired colonic motility in IBS patients with overweight and obesity. The literature search was conducted in the databases Embase, PubMed and Google Scholar using the keywords “irritable bowel syndrome”, “obesity”, “short-chain fatty acids”, “gut microbiota”.

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Typical dietary habits and elevated intestinal permeability in people with excess body weight and IBS

Cited by 6 publications

References 14 publications

Features of the course of irritable bowel syndrome in overweight and obese people

Features of the course of irritable bowel syndrome in overweight and obese people

Atrial fibrillation and the gut microbiota: is there a link?

Potential role of short-chain fatty acids in irritable bowel syndrome in overweight and obese individuals

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