Typical and atypical pulmonary carcinoids: our institutional experience

Abstract

Typical and atypical pulmonary carcinoids: our institutional experiencehttp://icvts.ctsnetjournals.org/cgi/content/full/7/3/415 located on the World Wide Web at:The online version of this article, along with updated information and services, is Abstract Pulmonary carcinoids are rare malignant neoplasms, accounting for 2-5% of all lung tumors, with an approximate annual incidence of 2.3-2.8 cases per million of the population. We relate our experience of 54 patients (21 male, 33 female, mean age 53"15 years) treated between July 1986 and April 2006. All the patients underwent preoperative fibrobronchoscopy: preoperative diagnosis was made in 28 patients (52%). Surgical treatment consisted of: 31 standard lobectomies, 6 pneumonectomies, 5 bilobectomies, 2 sleeve lobectomies, 2 anatomic segmentectomies, 6 wedge resections; two patients were managed with sleeve bronchial procedure of the left main bronchus without lung resection. Fifty-four patients were followed with a mean time of observation of 67 months: 6 (11%) deaths occurred, at a mean period of 49 months after surgery; there were no postoperative deaths. Overall, 5-year survival was 91%, 10 years 83%: 5-year survival was 91% for typical carcoinoids (TC) vs. 88% for atypical (AC), 10 years 91% for TC and 44% for AC (significant value, Ps0.0487). Carcinoid tumors are a distinct group of neuroendocrine tumors with a good prognosis in most cases. Surgery currently represents the best treatment with good results at mid-and long-term survival, according to an acceptable risk.

Tumeurs carcinoïdes bronchopulmonaires : une série tunisienne de 115 cas opérés

“…La voie d'abord standard est la thoracotomie (postéro-latérale ou latérale), notamment pour les tumeurs localement avancées ou proximales. L'abord vidéo-thoracoscopique (VATS) est de plus en plus indiqué et devenu actuellement un standard dans les cancers bronchiques de stades précoces [7,18]. Dans notre activité, la chirurgie vidéo-thoracoscopique dans les exérèses majeures a été récemment introduite, ce qui explique le nombre réduit de cas opérés par cette voie.…”

“…Dans la plupart des séries, la localisation endo-bronchique est plus fréquente. La tumeur peut être périphérique ; cette situation moins fréquente caractérise les tumeurs CA dont la taille est plus importante [18]. L'évolution métastatique à distance est possible pour les deux types de tumeurs CB mais à des degrés variables, ce qui impose une surveillance prolongée [30].…”

Outcomes after Surgical Resection of Pulmonary Carcinoid Tumors

“…Atypical carcinoid tumors do appear to have more aggressive biology, with statistically increased tumor size and propensity for lymph node metastases [9][10][11][12]. And while patients with atypical carcinoid tumors were more likely to develop recurrent disease, overall survival was not affected by typical/atypical histology.…”

Carcinóide Pulmonar: Análise de Experiência Institucional e Fatores Prognóstico

“…3 Em termos clínicos, são geralmente tumores centrais que cursam com obstrução brônquica. Os sintomas mais frequentes são a tosse ou hemoptise mas muitos doentes são assintomáti-cos. 4,5 Podem ocorrer em qualquer idade e não existe diferença entre os dois sexos. Relativamente ao prognóstico, quando comparados com outros carcinomas pulmonares de não pequenas células, os carcinóides apresentam geralmente um prognóstico favorável após ressecção cirúrgi-ca.…”