Typhoid Fever; Estimation of Serum Lipid Levels and C-Reactive Protein

Hassan, Zulfiqar-ul; Shafiq, Afrah; Saghir, Gulpash; Naseer, Rahat; Fatimah, Mufakhara; Malik, Mahwash; Hassan, Taha

doi:10.17957/tpmj/17.3621

Cited by 1 publication

(1 citation statement)

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“…In this study, patients with enteric fever showed a significant increase in the level of triglycerides compared to their controls. This finding agreed with that of a previous study which showed an elevation in the levels of triglycerides in patients with enteric fever [ 19 ]. This was unlike another study that showed hypocholesterolemia and hyper LDL-cholesterolemia as well as a non-significant change in triglyceride and HDL-cholesterol levels in typhoid fever [ 20 ].…”

Section: Discussionsupporting

confidence: 94%

Association of Biochemical and Hematological Parameters With Enteric Fever Infection at the Dschang Regional Annex Hospital, Cameroon: A Cross-Sectional Study

Etouke,

Ful Kuh,

Nzesseu

et al. 2023

Cureus

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BackgroundEnteric fever is a systemic infection in humans caused by the Gram-negative bacilli Salmonella enterica serovars Typhi and Paratyphi. Although the diagnosis typically involves the isolation of Salmonella enterica serovars, it is often determined based on laboratory findings and clinical observations. However, due to the wide variety and the non-specific character of clinical features, making a definitive diagnosis presents numerous challenges. Therefore, the aim of this study was to find the predictive hematological and biochemical parameters which would serve in the diagnosis, prognosis, and treatment of typhoid fever cases. MethodologyA cross-sectional study was conducted from November 2020 to September 2021 on 1076 consented volunteer participants. Stool culture and identification tests enabled us to distinguish three groups including 423 Salmonella Typhi positive patients, 115 S. Paratyphi positive patients, and 538 Salmonella negative participants. Biochemical and hematological parameters were evaluated using standard methods from commercial kits and Sysmex KX-21N automated hematology analyzer, respectively. A multiple logistic regression analysis was performed to identify the validity of the hematological and biochemical characteristics for enteric fever diagnosis. ResultsMultiple logistic regression showed hyper creatininemia, hypoalbuminemia, hyper total proteinemia, hyper alkaline phosphatase (ALP), hyper alanine aminotransferase (ALT), hyper total bilirubinemia, hyper conjugated bilirubinemia, hyper triglyceridemia, hyper C-reactive protein (CRP), leukopenia, thrombocytopenia, lymphopenia, monocytopenia, low hemoglobin, low hematocrit, low mean corpuscular volume (MCV), low mean corpuscular hemoglobin (MCH), low platelet, low platelet crit level, high platelet distribution width (PDW) level, high erythrocyte sedimentation rate 1 (ESR1) level as significant biological abnormalities associated (odds ratio {OR} > 1; p < 0.05) with enteric fever infection. Similarly, hyper ESR2 was an independent predictor (OR > 1; p < 0.05) of S. Typhi infection. However, a negative and significant association (OR < 1; p < 0.05) was recorded between enteric fever infection and high mean platelet volume (MPV). ConclusionOverall the results of the biochemical and hematological profiles can serve as potential diagnostic markers for typhoid fever. These markers can also be useful in the appropriate management of those with enteric fever, preventing severity and limiting outcomes of mortality.

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Section: Discussionsupporting

confidence: 94%