Typhoid and Paratyphoid Fever in 192 Hospitalized Children in Thailand

A Reappraisal of Clinical Characteristics of Typhoid Fever

“…However, its clinical presentation, pathological and biochemical manifestations and antimicrobial sensitivity pattern have changed significantly posing problem to diagnosis and management 5 . Agarwal and associates 6 reported clinical features of typhoid fever to be in conformity with earlier studies 7,8 and noted spleenomegaly in only less than one third of the cases. Multidrug resistant enteric fever is associated with prolonged duration of fever, hepatomegaly, more complication and higher mortality [9][10][11] .…”

Clinical profile and Outcome of Enteric Fever in hospitalized children aged 6 months to 2 years

“…21 A n emia (70%) as well as abdominal distention (75%) were common in our study population. Abdominal tenderness, which can be diagnostically important in children 22 was present in 20% of cases. Hepatomegaly was noted in 37.5% of children which is similar (35%) to that of an Ethiopian study while it was the feature of 42% in South African and 27% in Nigerian children with typhoid fever.…”

Enteric Fever Due To Multi-Resistant Salmonella Typhi

“…Due to the rare but dreadful bone marrow toxicity of chloramphenicol and the worldwide spread of strains of S. typhi resistant to this antibiotic, other drugs were tried in the treatment of typhoid and paratyphoid fevers [6]. Ampicillin, amoxicillin, and cotrimoxazole gave comparable efficacy to chloramphenicol [16,17]. In addition, these three first line drugs were also successfully used in the treatment of chloramphenicol-resistant typhoid fever [1,18] and the management of carriers [6].…”