Types of T-cell lymphoma-a cytogenetic perspective

Samad, Muhammad Ammar; Mahboob, Eman; Shafiq, Aimen; Rehman, Mohammad Hassam Ur; Sheikh, Ayesha; Tharwani, Zoaib Habib

doi:10.1016/j.amsu.2022.104844

Cited by 4 publications

(3 citation statements)

References 91 publications

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“…Furthermore, this lymphoma tends to progress rapidly. Initial treatment is often successful, but recurrence of the lymphoma is common 9 , 10 .…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Molla,

Answar,

Worku

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction and importance: Paraneoplastic pemphigus is an uncommon autoimmune mucocutaneous disease characterized by severe stomatitis, polymorphous skin eruptions, and the presence of underlying neoplasms. Unique histopathological features include suprabasal acantholysis and clefts with scattered necrotic keratinocytes. Case presentation: A 27-year-old female patient presented with a three-month history of a painless swelling, approximately the size of a pea, on the left lateral aspect of her neck and axillary area. This swelling progressively increased in size and number. Additionally, she had reddish, itchy, raised skin lesions over her elbows bilaterally, which gradually spread to involve most of her body, including her lips, tongue, and buccal mucosa. These skin lesions were associated with difficulty swallowing both liquid and solid foods. A diagnostic test, including a biopsy, confirmed the diagnosis of paraneoplastic pemphigus. Subsequently, the patient was managed with chemotherapy and other supportive measures, leading to improvement and eventual discharge. Clinical discussion: Paraneoplastic pemphigus is a rare blistering disorder associated with neoplasms, often presenting diagnostic and treatment challenges. Patients with PNP may develop a diverse range of lesions. It is crucial to promptly recognize and manage the underlying malignancy for improved patient outcomes. Conclusion: This case highlights the rare association between T-cell lymphoma and paraneoplastic pemphigus. Clinicians should also remain vigilant for the possibility of paraneoplastic pemphigus in lymphomas that are not of B-cell lineage.

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“…Furthermore, this lymphoma tends to progress rapidly. Initial treatment is often successful, but recurrence of the lymphoma is common 9 , 10 .…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Molla,

Answar,

Worku

et al. 2024

Annals of Medicine &Amp; Surgery

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“…Firstly, animals showed signs of anxiety -/depression-like behavior. Numerous reports describe such effects of arsenic [117][118][119], although those effects were observed after a longer time of exposure. These findings indicate the complexity of As's effects, in that the aforementioned behavioral symptoms are regulated by a wide variety of brain regions, among them the loss of interest in feed-uptake involves the hypothalamus and its "hunger cells" (AgRP neurons) and "satiety cells" (POMC neurons).…”

Section: Mitochondrial Ultrastructurementioning

confidence: 99%

Analysis of arsenic-modulated expression of hypothalamic estrogen receptor, thyroid receptor, and peroxisome proliferator-activated receptor gamma mRNA and simultaneous mitochondrial morphology and respiration rates in the mouse

Alymbaeva,

Szabo,

Jocsak

et al. 2024

PLoS ONE

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Arsenic has been identified as an environmental toxicant acting through various mechanisms, including the disruption of endocrine pathways. The present study assessed the ability of a single intraperitoneal injection of arsenic, to modify the mRNA expression levels of estrogen- and thyroid hormone receptors (ERα,β; TRα,β) and peroxisome proliferator-activated receptor gamma (PPARγ) in hypothalamic tissue homogenates of prepubertal mice in vivo. Mitochondrial respiration (MRR) was also measured, and the corresponding mitochondrial ultrastructure was analyzed. Results show that ERα,β, and TRα expression was significantly increased by arsenic, in all concentrations examined. In contrast, TRβ and PPARγ remained unaffected after arsenic injection. Arsenic-induced dose-dependent changes in state 4 mitochondrial respiration (St4). Mitochondrial morphology was affected by arsenic in that the 5 mg dose increased the size but decreased the number of mitochondria in agouti-related protein- (AgRP), while increasing the size without affecting the number of mitochondria in pro-opiomelanocortin (POMC) neurons. Arsenic also increased the size of the mitochondrial matrix per host mitochondrion. Complex analysis of dose-dependent response patterns between receptor mRNA, mitochondrial morphology, and mitochondrial respiration in the neuroendocrine hypothalamus suggests that instant arsenic effects on receptor mRNAs may not be directly reflected in St3-4 values, however, mitochondrial dynamics is affected, which predicts more pronounced effects in hypothalamus-regulated homeostatic processes after long-term arsenic exposure.

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“…miRNAs for diagnosis have been of research interest in cancers for a long time now. Its application in the diagnosis of T-cell malignancies is, however, of more importance given the wide range of pathobiological, clinical, and cytogenetic variations in its malignant subtypes ( 150 ). To avoid inaccurate clinical judgment ( 151 ), it is essential to devise new methods of diagnosis that cannot only capture specific tumor markers but also quantify molecular variations among overlapping clinical features.…”

Section: Applicability Of Mirna-based Diagnosis and New Avenuesmentioning

confidence: 99%

Diagnostic significance of dysregulated miRNAs in T-cell malignancies and their metabolic roles

et al. 2023

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T-cell malignancy is a broad term used for a diverse group of disease subtypes representing dysfunctional malignant T cells transformed at various stages of their clonal evolution. Despite having similar clinical manifestations, these disease groups have different disease progressions and diagnostic parameters. The effective diagnosis and prognosis of such a diverse disease group demands testing of molecular entities that capture footprints of the disease physiology in its entirety. MicroRNAs (miRNAs) are a group of noncoding RNA molecules that regulate the expression of genes and, while doing so, leave behind specific miRNA signatures corresponding to cellular expression status in an altered stage of a disease. Using miRNAs as a diagnostic tool is justified, as they can effectively distinguish expressional diversity between various tumors and within subtypes of T-cell malignancies. As global attention for cancer diagnosis shifts toward liquid biopsy, diagnosis using miRNAs is more relevant in blood cancers than in solid tumors. We also lay forward the diagnostic significance of miRNAs that are indicative of subtype, progression, severity, therapy response, and relapse. This review discusses the potential use and the role of miRNAs, miRNA signatures, or classifiers in the diagnosis of major groups of T-cell malignancies like T-cell acute lymphoblastic lymphoma (T-ALL), peripheral T-cell lymphoma (PTCL), extranodal NK/T-cell lymphoma (ENKTCL), and cutaneous T-cell lymphoma (CTCL). The review also briefly discusses major diagnostic miRNAs having prominent metabolic roles in these malignancies to highlight their importance among other dysregulated miRNAs.

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Types of T-cell lymphoma-a cytogenetic perspective

Cited by 4 publications

References 91 publications

Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Paraneoplastic pemphigus in a patient with T-cell lymphoma, a case report

Analysis of arsenic-modulated expression of hypothalamic estrogen receptor, thyroid receptor, and peroxisome proliferator-activated receptor gamma mRNA and simultaneous mitochondrial morphology and respiration rates in the mouse

Diagnostic significance of dysregulated miRNAs in T-cell malignancies and their metabolic roles

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