Types of necroinflammation, the effect of cell death modalities on sterile inflammation

Mázló, Anett; Jenei, Viktória; Burai, Sára; Molnár, Tamás; Bácsi, Attila; Koncz, Gábor

doi:10.1038/s41419-022-04883-w

Cited by 26 publications

(21 citation statements)

References 154 publications

(121 reference statements)

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“…Meanwhile, KEGG analysis also revealed that NRGs could play a role in Th1 and Th2 cell differentiation, Antigen processing and presentation, Th17 cell differentiation, cytokine − cytokine receptor interaction, and Natural killer cell-mediated cytotoxicity pathways. Th1/Th2 imbalance was involved in necroptosis-mediated inflammation [ 47 ]. RIPK1 inhibition could down-regulate Th1 and Th17 cell levels but promote Th2 and Treg cell levels in collagen-induced arthritis [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer

Nie

Chen

et al. 2023

J Ovarian Res

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Background Necroptosis is a novel type of programmed cell death distinct from apoptosis. However, the role of necroptosis in ovarian cancer (OC) remains unclear. The present study investigated the prognostic value of necroptosis-related genes (NRGs) and the immune landscape in OC. Methods The gene expression profiling and clinical information were downloaded from the TCGA and GTEx databases. Differentially expressed NRGs (DE-NRGs) between OC and normal tissueswere identified. The regression analyses were conducted to screen the prognostic NRGs and construct the predictive risk model. Patients were then divided into high- and low-risk groups, and the GO and KEGG analyses were performed to explore bioinformatics functions between the two groups. Subsequently, the risk level and immune status correlations were assessed through the ESTIMATE and CIBERSORT algorithms. The tumor mutation burden (TMB) and the drug sensitivity were also analyzed based on the two-NRG signature in OC. Results Totally 42 DE-NRGs were identified in OC. The regression analyses screened out two NRGs (MAPK10 and STAT4) with prognostic values for overall survival. The ROC curve showed a better predictive ability in five-year OS using the risk score. Immune-related functions were significantly enriched in the high- and low-risk group. Macrophages M1, T cells CD4 memory activated, T cells CD8, and T cells regulatory infiltration immune cells were associated with the low-risk score. The lower tumor microenvironment score was demonstrated in the high-risk group. Patients with lower TMB in the low-risk group showed a better prognosis, and a lower TIDE score suggested a better immune checkpoint inhibitor response in the high-risk group. Besides, cisplatin and paclitaxel were found to be more sensitive in the low-risk group. Conclusions MAPK10 and STAT4 can be important prognosis factors in OC, and the two-gene signature performs well in predicting survival outcomes. Our study provided novel ways of OC prognosis estimation and potential treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer

Nie

Chen

et al. 2023

J Ovarian Res

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“…Activated inflammatory cells release reactive oxygen species (ROS), damaging bystander cells in a process exacerbated by restoration of oxygen delivery [3]. Cell death occurs via multiple potential pathways, releasing more DAMPs and potentiating further inflammation [4 ▪ ,5]. This can precipitate a cytokine storm [6 ▪ ] and a vicious cycle of gross disruption to many physiological processes.…”

Section: Mechanisms Of Biochemical Disturbancementioning

confidence: 99%

Biochemical disturbance in damage control resuscitation: mechanisms, management and prognostic utility

Milne¹,

Radhakrishnan²

2022

Current Opinion in Anaesthesiology

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Purpose of reviewWith advances in resuscitative techniques, trauma patients are surviving increasingly severe injuries and physiological insult. Timely recognition of futility remains important in terms of patient dignity and resource preservation yet is increasingly challenging in the face of these advances. The understanding of biochemical derangement from pathophysiological processes of trauma and iatrogenic effects of resuscitation has expanded recently.Recent findingsAcidosis and hypocalcaemia have been recognized as important contributors to mortality among trauma patients. Although less well recognized and studied, critical injury and high blood product volume resuscitation render patients vulnerable to life-threatening hyperkalaemia. The methods of correcting disruptions to acid–base and electrolyte homeostasis during damage control resuscitation have changed little recently and often rely on evidence from undifferentiated populations. Biochemical disturbances have value as ancillary predictors of futility in trauma resuscitation.SummaryThese findings will contribute to a greater understanding among anaesthesiologists of the causative mechanisms and effects of biochemical derangement after severe injury and aid them in the delivery of well tolerated and effective damage control resuscitation. Gaps in the evidence base are highlighted to encourage future work.

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“…Cell death is the primary source of extracellular DNA (ecDNA). This DNA is considered a byproduct of cell death and, generally, it will be eliminated swiftly without activation of the host’s immune system [ 6 , 7 , 8 ]. However, if the immune function is compromised or if processing capacity reaches saturation, ecDNA can be dangerous, as it interacts with various nucleic acid sensors.…”

Section: Introductionmentioning

confidence: 99%

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

Wang

Stehr

Singh

et al. 2023

IJMS

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During inflammatory responses, neutrophils enter the sites of attack where they execute various defense mechanisms. They (I) phagocytose microorganisms, (II) degranulate to release cytokines, (III) recruit various immune cells by cell-type specific chemokines, (IV) secrete anti-microbials including lactoferrin, lysozyme, defensins and reactive oxygen species, and (V) release DNA as neutrophil extracellular traps (NETs). The latter originates from mitochondria as well as from decondensed nuclei. This is easily detected in cultured cells by staining of DNA with specific dyes. However, in tissues sections the very high fluorescence signals emitted from the condensed nuclear DNA hamper the detection of the widespread, extranuclear DNA of the NETs. In contrast, when we employ anti-DNA-IgM antibodies, they are unable to penetrate deep into the tightly packed DNA of the nucleus, and we observe a robust signal for the extended DNA patches of the NETs. To validate anti-DNA-IgM, we additionally stained the sections for the NET-markers histone H2B, myeloperoxidase, citrullinated histone H3, and neutrophil elastase. Altogether, we have described a fast one-step procedure for the detection of NETs in tissue sections, which provides new perspectives to characterize neutrophil-associated immune reactions in disease.

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Types of necroinflammation, the effect of cell death modalities on sterile inflammation

Cited by 26 publications

References 154 publications

Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer

Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer

Biochemical disturbance in damage control resuscitation: mechanisms, management and prognostic utility

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

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