Types of Endoscopic Endonasal Resections for Sinonasal Malignancies

Tosun, Fuat; Yildizoglu, Uzeyir; Polat, Bahtiyar; Durmaz, Abdullah

doi:10.1097/scs.0000000000000455

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tosun et al. divided 20 patients with SNM treated with EEA into four categories by type of resection: en bloc ( n = 5), piecemeal resection of intranasal and en bloc resection of the tumor origin site ( n = 6), piecemeal resection of both intranasal and tumor origin sites with curative intent ( n = 4), and resection with palliative intent or removal with a positive margin ( n = 5) 134 . Local recurrence was observed only in the final group at mean follow‐up of 4 years, suggesting that piecemeal resection does not lead to an increase in local recurrence.…”

Section: Principles Of Surgical Treatmentmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

show abstract

Section: Principles Of Surgical Treatmentmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

“…Despite early concerns regarding the oncologic acceptability of piecemeal rather than en bloc tumor resection utilized in EEAs, 9 there is now broad consensus that the goal of complete resection, rather than the method of resection, should guide a surgeon's approach. 10,11 As such, efforts are ongoing to continue to delineate indications, limitations, and techniques of entirely EEAs. However, there remain significant gaps in knowledge due in part to variations among different institutions' familiarity, surgical aggressiveness, and operative goals.…”

Section: Introductionmentioning

confidence: 99%

Extent of Endoscopic Resection for Anterior Skull Base Tumors: An MRI-Based Volumetric Analysis

et al. 2016

View full text Add to dashboard Cite

To determine the volume of ventral skull base tumor removed following endoscopic endonasal (EEA) resection using MRI-based volumetric analysis and to evaluate the inter-rater reliability of such analysis. Retrospective case series. Academic tertiary care hospital. EEA patients November 2012 to August 2015. Volumetric analysis of pre- and immediately postoperative MR imaging was performed independently by two investigators. The percentage of total tumor resected was evaluated according to resection goal and tumor type. A total of 39 patients underwent resection. Intraclass correlation coefficients between the raters were 0.9988 for preoperative and 0.9819 for postoperative images. Tumors (and average percentage removed) included 17 nonsecreting pituitary adenomas (95.3%), 8 secreting pituitary adenomas (86.2%), 4 meningiomas (81.6%), 3 olfactory neuroblastomas (100%), 2 craniopharyngiomas (100%), 1 large B-cell lymphoma (90.5%), 1 germ cell neoplasm (48.3), 1 benign fibrous connective tissue mass (93.4%), 1 epidermoid cyst (68.4%), and 1 chordoma (100%). For tumors treated with intent for gross total resection, 96.9 ± 4.8% was removed. EEAs achieved tumor resection rates of ∼97% when total resection was attempted. The radiographic finding of residual tumor is of uncertain clinical significance. The volumetric analysis employed in this study demonstrated high inter-rater reliability and could facilitate further study.

show abstract

Hypoxia regulates IL-17A secretion from nasal polyp epithelial cells

et al. 2017

View full text Add to dashboard Cite

Hypoxia creates a microenvironment conducive to polypogenesis by regulating immune responses of the nasal polyp (NP) epithelium. We explored the immunocompetence of NP and control epithelial cells in response to hypoxia, to investigate potential relationships with polypogenesis. Three groups of tissue samples were collected: inferior turbinate (IT)and NP from individuals with chronic rhinosinusitis with NPs (CRSwNP), and control IT. A positive relationship was detected between HIF1α, HIF2α protein expression in epithelial cells and endoscope score in NP samples, while there was a negative correlation between HIF1α expression and degree of eosinophil infiltration. Epithelial IL-17A expression was lower in NPs than in IT samples from either controls or patients with CRSwNP. Primary human nasal epithelial cells were cultured under hypoxic or normoxic conditions. Enzyme-linked immunosorbent assays demonstrated decreased IL-17A expression upon prolonged exposure to hypoxia in both IT and NP samples from patients with CRSwNP, while IL-17A increased in control IT epithelial cells; correlation and time-dependency were observed between HIF1α and IL-17A expression in both IT and NP samples from patients with CRSwNP. These observations suggest that hypoxia is involved in the pathogenesis of NPs through regulation of IL-17A secretion and HIF1α and HIF2α expression in the NP epithelium.

show abstract

Types of Endoscopic Endonasal Resections for Sinonasal Malignancies

Abstract: Classification of endoscopic tumor resection used in the present study may help preoperative planning.

Cited by 3 publications

References 13 publications

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Extent of Endoscopic Resection for Anterior Skull Base Tumors: An MRI-Based Volumetric Analysis

Hypoxia regulates IL-17A secretion from nasal polyp epithelial cells

Contact Info

Product

Resources

About