Types, frequency and impact of asthma triggers on patients’ lives: a quantitative study in five European countries

Price, David; Dale, Peter; Elder, E Scott; Chapman, Kenneth R.

doi:10.3109/02770903.2013.846369

Cited by 23 publications

(24 citation statements)

References 30 publications

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“…Ion channels on the termini of airway sensory fibres located under the airway epithelium make them capable of directly responding to a diverse range of agents, many of which correspond to triggers of asthma symptoms identified by patients, including changes in temperature, humidity, pollution and irritant chemicals such as cigarette smoke, cleaning products, perfumes, etc. [228,232], as well perhaps to changes in airway calibre during bronchospasm [233], Neuronal dysfunction in animal models of asthma can also be induced by eosinophils [234], viruses [235] and mediators such as neurotrophins [236,237] and can mediate induction of AHR by β 2 -agonists [238].…”

Section: Airway Nerves and Neural Pathwaysmentioning

confidence: 99%

Addressing unmet needs in understanding asthma mechanisms

et al. 2017

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Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

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Section: Airway Nerves and Neural Pathwaysmentioning

confidence: 99%

Addressing unmet needs in understanding asthma mechanisms

et al. 2017

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“…The reality is that the multifaceted initiatives are falling short of addressing the multifactorial issues associated with sub-optimal management in real life [2,10,11,[15][16][17][18]: issues spanning across patient, healthcare practitioners and healthcare-system domains [12,19].…”

Section: @Erspublicationsmentioning

confidence: 99%

Asthma management in primary care: caring, sharing and working together

Bosnic‐Anticevich

2016

Eur Respir J

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@ERSpublicationsWhy aren't primary care physicians and pharmacists collaborating more to manage and monitor asthma medication issues? http://ow.ly/YB2p6While historically chronic illnesses have been "stewarded" by different practitioners in different countries [1] with the increasing number of people with chronic illnesses and the ever rising costs of healthcare, the primary care setting is viewed as the long-term custodian of chronic illness management [2][3][4]. For people with asthma, quality management in primary care is a real, viable and accessible solution to asthma care. This is reflected in guidelines [2,5, 6], in research trends (as we see pragmatic research sourcing participants in primary care) [7,8] and it is evidenced in a multitude of primary healthcare initiatives established to support primary care physicians to optimally manage asthma in the community.Optimal asthma management: are we achieving it? Or is it an enigma? These are questions that primary care researchers and healthcare practitioners have been burdened with for a long time. Why? Because evidence, from large-scale and population-based studies confirms that, despite our ever-increasing knowledge and the abundance of research in the practice/clinical field, asthma remains a major health and economic burden. It is estimated that ∼300 million people live with asthma world-wide [2] and a high proportion of people living with asthma are classified as having poorly controlled disease [4,[9][10][11][12][13]. Asthma has significant economic impact both on individuals and on the healthcare system. A recent report determined that the net annual value of the burden of disease of asthma in Australia (based on disability-adjusted life years) was AUD 24.7 billion, with projected government costs for 2016-2019 being AUD 4.0 billion [14].For primary care practitioners, the current status of asthma in the community is at the very least disappointing, if not frightening; especially given the efforts put into improving asthma care at all levels (health system, research, global reports, practice initiatives, patient support and public awareness). The reality is that the multifaceted initiatives are falling short of addressing the multifactorial issues associated with sub-optimal management in real life [2,10,11,[15][16][17][18]: issues spanning across patient, healthcare practitioners and healthcare-system domains [12,19].One of the major issues in practice is asthma medication use. Medication management is a well-recognised, documented and investigated aspect of asthma management. Consistently research and practice indicate that many of the issues associated with sub-optimal management of asthma are related to the way in which people use their medicines, i.e. a high proportion of patients are nonadherent and a majority do not master or maintain correct inhaler technique [9,10]. Effective solutions to inappropriate and incorrect asthma medication use have been identified through high quality research; however, if these strategies are being implemented in...

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“…The next step could be correlating these trigger factors to disease control, symptoms, exacerbation and healthcare utilisation. Although this was done for asthma patients in prior studies, (40,41) there is a need for validation in the Asian setting. Clinically important trigger factors could be used to design management programmes that incorporate mitigation of exposure to aggravating substances.…”

Section: Discussionmentioning

confidence: 99%

Trigger factors in asthma and chronic obstructive pulmonary disease: a single-centre cross-sectional survey

See

Phua

Lim

2016

smedj

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INTRODUCTIONThe presence of trigger factors may help to distinguish asthma from chronic obstructive pulmonary disease (COPD). Knowing and avoiding trigger factors for both asthma and COPD can facilitate the design of comprehensive management programmes that can aid disease control. This study aimed to describe the relative frequency and range of various trigger factors in asthma and COPD. METHODSWe conducted a telephone-based survey involving asthma and COPD patients on follow-up at a university hospital in Singapore.RESULTS A total of 779 asthma patients and 129 COPD patients participated in this study. Among these patients, 93.8% of those with asthma and 42.6% of those with COPD had trigger factors (p < 0.001). The median number of trigger factors was greater among asthma patients than among those with COPD (3 vs. 0, p < 0.001). Trigger factors found to be significantly more prevalent among asthma patients compared to those with COPD include tobacco smoke, alcohol, upper respiratory tract infections, incense smoke, perfume, laughter, a dusty environment, air-conditioning, heavy rain, heavy traffic fumes, citrus fruits, gastro-oesophageal reflux, household pets, flowers/pollen, medications and psychological triggers. Trigger factors that were not previously described, such as bathing, fatigue, insufficient sleep, crowded places and overeating, were also reported. CONCLUSIONTrigger factors, although found in both groups of patients, were more common among asthma patients.Knowledge of these trigger factors may be useful in distinguishing between the two diseases and optimising disease management.

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Types, frequency and impact of asthma triggers on patients’ lives: a quantitative study in five European countries

Cited by 23 publications

References 30 publications

Addressing unmet needs in understanding asthma mechanisms

Addressing unmet needs in understanding asthma mechanisms

Asthma management in primary care: caring, sharing and working together

Trigger factors in asthma and chronic obstructive pulmonary disease: a single-centre cross-sectional survey

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