Types, Clinical Features, and Survival Outcomes of Patients with Acute Myeloid Leukemia in Thailand: A 3-Year Prospective Multicenter Study from the Thai Acute Leukemia Study Group (TALSG)

Wanitpongpun, Chinadol; Utchariyaprasit, Eakkapol; Owattanapanich, Weerapat; Tantiworawit, Adisak; Rattarittamrong, Ekarat; Niparuck, Pimjai; Puavilai, Teeraya; Julamanee, Jakrawadee; Saelue, Pirun; Chanswangphuwana, Chantiya; Polprasert, Chantana; Nakhakes, Chajchawan; Limvorapitak, Wasithep; Kanitsap, Nonglak; Prayongratana, Kannadit; Sriswasdi, Chantrapa

doi:10.1016/j.clml.2021.03.004

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…The biopsy confirmed the presence of an AML-MD, which the skin biopsy confirmed by showing dermal leukaemia cutis, which is an infrequent phenomenon [ 5 ] . It is even more unusual for a patient with AML not to have circulating myeloblasts at the time of diagnosis; it has also been demonstrated especially in acute promyelocytic leukaemia [ 6 , 7 ] . Some cases are described where skin presentation precedes the appearance of immature cells in the blood [ 8 ] .…”

Section: Discussionmentioning

confidence: 99%

Acute Myeloid Leukaemia Presenting as B12 Vitamin Deficiency When Multiple Horses Become a Zebra

Ferrão

Gonçalves

Almeida

2022

European Journal of Case Reports in Internal Medicine

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Vitamin B12 deficiency is a common finding in medical practice. It is easily treated with supplementation and typically has a favourable prognosis. In rare circumstances, it can hide a severe disease that should be promptly addressed. We report the case of an acute myeloid leukaemia presenting as an initially predictable B12 deficiency in a vegetarian patient with chronic gastritis. The supplementation rapidly corrected the deficit and the accompanying cytopenias. However, in the following month the cell counts fell once again, leading to the suspicion that other aetiology could be lying beneath the surface. Maintaining a normal peripheral blood smear, the bone marrow biopsy showed myeloblasts and extensive fibrosis compatible with the diagnosis of acute myeloid leukaemia. The neoplasm justified the vitamin deficit by excessive cellular turnover, a vicious cycle only uncovered after supplementation and that ultimately led to the patient’s death.

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Section: Discussionmentioning

confidence: 99%

Acute Myeloid Leukaemia Presenting as B12 Vitamin Deficiency When Multiple Horses Become a Zebra

Ferrão

Gonçalves

Almeida

2022

European Journal of Case Reports in Internal Medicine

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The cost–utility analysis of antifungal prophylaxis for invasive fungal infections in acute myeloid leukaemia patients receiving chemotherapy: a study from a middle-income country

Pungprasert,

Dhirachaikulpanich,

Phutthasakda

et al. 2024

Journal of Hospital Infection

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Simplified predictive scores for thrombosis and bleeding complications in newly diagnosed acute leukemia patients

Owattanapanich,

Rungjirajittranon,

Jantataeme

et al. 2023

Thrombosis J

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Background Bleeding and thrombotic complications are the leading causes of death in acute leukemia patients. The Conventional International Society of Thrombosis and Haemostasis Disseminated Intravascular Coagulation (ISTH DIC) scoring system is utilized to assess DIC diagnoses in various conditions. Nevertheless, limited studies have tested the system’s accuracy in predicting thrombo-hemorrhagic events in individuals with acute leukemia. This study aimed to (1) validate the ISTH DIC scoring system and (2) propose a new Siriraj Acute Myeloid/Lymphoblastic Leukemia (SiAML) bleeding and thrombosis scoring system for thrombohemorrhagic risk assessment in acute leukemia. Methods We conducted a retro-prospective observational study of newly diagnosed acute leukemia patients between March 2014 and December 2019. We recorded thrombohemorrhagic episodes within 30 days postdiagnosis and DIC profiles, including prothrombin time, platelet level, D-dimer, and fibrinogen. The sensitivities, specificities, positive and negative predictive values, and areas under receiver operating characteristic curves for the ISTH DIC and SiAML scoring systems were calculated. Results In all, 261 acute leukemia patients were identified: 64% with acute myeloid leukemia, 27% with acute lymphoblastic leukemia, and 9% with acute promyelocytic leukemia. Overall bleeding and thrombotic events were 16.8% and 6.1%, respectively. With a cutoff of 5 for the ISTH DIC score, the sensitivity and specificity for bleeding prediction were 43.5% and 74.4%, respectively, while the corresponding values for thrombotic prediction were 37.5% and 71.8%, respectively. D-dimer > 5000 µg FEU/L and fibrinogen ≤ 150 mg/dL were significantly associated with bleeding. A SiAML-bleeding score was calculated using these factors, with a sensitivity and specificity of 65.2% and 65.6%, respectively. Conversely, D-dimer > 7000 µg FEU/L, platelet > 40 × 109/L, and white blood cell level > 15 × 109/L were significant variables related to thrombosis. Using these variables, we established a SiAML-thrombosis score with a sensitivity and specificity of 93.8% and 66.1%, respectively. Conclusions The proposed SiAML scoring system might be valuable for prognosticating individuals at risk for bleeding and thrombotic complications. Prospective validation studies are needed to verify its usefulness.

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Types, Clinical Features, and Survival Outcomes of Patients with Acute Myeloid Leukemia in Thailand: A 3-Year Prospective Multicenter Study from the Thai Acute Leukemia Study Group (TALSG)

Cited by 3 publications

References 41 publications

Acute Myeloid Leukaemia Presenting as B12 Vitamin Deficiency When Multiple Horses Become a Zebra

Acute Myeloid Leukaemia Presenting as B12 Vitamin Deficiency When Multiple Horses Become a Zebra

The cost–utility analysis of antifungal prophylaxis for invasive fungal infections in acute myeloid leukaemia patients receiving chemotherapy: a study from a middle-income country

Simplified predictive scores for thrombosis and bleeding complications in newly diagnosed acute leukemia patients

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