Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid

Chandrasekaran, Prashant; Kwok, Bryan; Han, Biao; Adams, Sheila M.; Wang, Chao; Chery, Daphney R.; Mauck, Robert L.; Dyment, Nathaniel A.; Lü, Xin; Frank, David B.; Koyama, Eiki; Birk, David E.; Han, Lin

doi:10.1016/j.matbio.2021.07.002

Cited by 11 publications

(9 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the different stages, discs at 3 w were found to have the most abundant and active ECM expression. These discs showed high expression levels of both the early-stage markers Col3a1 and Col5a1 and the late-stage markers Comp and Dcn, which are vital for the structural stability of the ECM and mechanical strength sensing of fibrocartilage [35][36][37][38] . In other words, discs at this stage, while growing in size via cell proliferation, also become sturdier in order to respond to mechanical force by secreting specific ECM components.…”

Section: Fbs Show Heterogeneity In Tmj Disc Development and Agingmentioning

confidence: 99%

A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

Yin

et al. 2023

Nat Commun

View full text Add to dashboard Cite

The biological characteristics of the temporomandibular joint disc involve complex cellular network in cell identity and extracellular matrix composition to modulate jaw function. The lack of a detailed characterization of the network severely limits the development of targeted therapies for temporomandibular joint-related diseases. Here we profiled single-cell transcriptomes of disc cells from mice at different postnatal stages, finding that the fibroblast population could be divided into chondrogenic and non-chondrogenic clusters. We also find that the resident mural cell population is the source of disc progenitors, characterized by ubiquitously active expression of the NOTCH3 and THY1 pathways. Lineage tracing reveals that Myh11+ mural cells coordinate angiogenesis during disc injury but lost their progenitor characteristics and ultimately become Sfrp2+ non-chondrogenic fibroblasts instead of Chad+ chondrogenic fibroblasts. Overall, we reveal multiple insights into the coordinated development of disc cells and are the first to describe the resident mural cell progenitor during disc injury.

show abstract

Section: Fbs Show Heterogeneity In Tmj Disc Development and Agingmentioning

confidence: 99%

A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

Yin

et al. 2023

Nat Commun

View full text Add to dashboard Cite

show abstract

“…Importantly, the increases in Col2𝛼1 and Acan, as the main ECM proteins in matured cartilage, and decreases in MMP13 and Col1a2, as important indicators for the differentiation of mature chondrocytes toward hypertrophy, illustrated that chondrocytes better maintained their phenotype on the soft micropillar substrate. In addition, the increase of Col5𝛼l, that plays a vital role in mediating the progenitor cell niche of cartilage, [45] and Col6𝛼1, that locates at the direct vicinity of chondrocytes and protects cartilage from degradation via proteolysis resistance, [46] further elucidated the phenotype maintenance on soft micropillar substrates, although the basic expression levels of these two proteins cannot be compared to Col2𝛼1 at all. [47,48] We then performed qPCR and confirmed these gene changes of Col2a1, Acan, MMP13, and Col1a2 (Figure 2i).…”

Section: Patterned Equidistant Soft Micropillar Substrates Enhance Ch...mentioning

confidence: 99%

Biomimetic Fibers Based on Equidistant Micropillar Arrays Determines Chondrocyte Fate via Mechanoadaptability

Zhou,

Yang,

Duan

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

It is recognized that the changes in the physical properties of extracellular matrix result in fine‐tuned cell responses including cell morphology, proliferation and differentiation. In this study, a novel patterned equidistant micropillar substrate based on polydimethylsiloxane (PDMS) was designed to mimic the collagen fiber‐like network of the cartilage matrix. By changing the component of the curing agent to an oligomeric base, we obtained micropillar substrates with the same topology but different stiffnesses and found that chondrocytes seeded onto the soft micropillar substrate maintain their phenotype by gathering type II collagen and aggrecan more effectively than those seeded onto the stiff micropillar substrate. Moreover, chondrocytes sensed and responded to micropillar substrates with different stiffnesses by altering the ECM‐cytoskeleton‐focal adhesion axis. We then found that the soft substrate‐preserved chondrocyte phenotype was dependent on the activation of Wnt/β‐catenin signaling at a high expression level. Finally, we indicated the changes in osteoid‐like region formation and cartilage phenotype loss in the stiffened sclerotic area of osteoarthritis mouse cartilage to validate the cell behavior changes triggered by micropillar substrates with different stiffnesses. This study provided the change in cell behaviors that are more similar to those of real chondrocytes at tissue level during the transition from a normal state to a state of osteoarthritis.This article is protected by copyright. All rights reserved

show abstract

“…Collagens are the most common family, with more than 20 distinct collagen types recognized currently [ 97 , 98 , 99 , 100 ]. Collagens are essential for the production of extracellular matrix fibrillar and microfibrillar networks, basement membranes, and other extracellular matrix structures [ 101 , 102 ].…”

Section: Recent Advancements In Biopolymers-derived Materials For Sup...mentioning

confidence: 99%

Biopolymers-Derived Materials for Supercapacitors: Recent Trends, Challenges, and Future Prospects

et al. 2022

View full text Add to dashboard Cite

Supercapacitors may be able to store more energy while maintaining fast charging times; however, they need low-cost and sophisticated electrode materials. Developing innovative and effective carbon-based electrode materials from naturally occurring chemical components is thus critical for supercapacitor development. In this context, biopolymer-derived porous carbon electrode materials for energy storage applications have gained considerable momentum due to their wide accessibility, high porosity, cost-effectiveness, low weight, biodegradability, and environmental friendliness. Moreover, the carbon structures derived from biopolymeric materials possess unique compositional, morphological, and electrochemical properties. This review aims to emphasize (i) the comprehensive concepts of biopolymers and supercapacitors to approach smart carbon-based materials for supercapacitors, (ii) synthesis strategies for biopolymer derived nanostructured carbons, (iii) recent advancements in biopolymer derived nanostructured carbons for supercapacitors, and (iv) challenges and future prospects from the viewpoint of green chemistry-based energy storage. This study is likely to be useful to the scientific community interested in the design of low-cost, efficient, and green electrode materials for supercapacitors as well as various types of electrocatalysis for energy production.

show abstract

Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid

Cited by 11 publications

References 80 publications

A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

Biomimetic Fibers Based on Equidistant Micropillar Arrays Determines Chondrocyte Fate via Mechanoadaptability

Biopolymers-Derived Materials for Supercapacitors: Recent Trends, Challenges, and Future Prospects

Contact Info

Product

Resources

About