Type-specific herpes simplex virus-1 and herpes simplex virus-2 seroprevalence in Romania: comparison of prevalence and risk factors in women and men

Aramă, Victoria; Streinu-Cercel, Adrian; Vlădăreanu, Radu; Mihai, Carina; Mihăilescu, Raluca; Rankin, J.; Goschin, S.; Filipescu, Alexandru; Rafilă, Alexandru; Aramă, Ștefan Sorin; Hristea, Adriana; Malkin, Jean-Elie; Pimenta, Jeanne M.; Smith, Jennifer S.

doi:10.1016/j.ijid.2009.07.026

Cited by 18 publications

(21 citation statements)

References 19 publications

(27 reference statements)

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“…Studies from general population and low-risk populations from Eastern Europe showed an HSV-2 seroprevalence that was either comparable to [23] or lower than [24–26] what we observed. One study showed great variations in seroprevalence in Europe, from 24 % in Bulgaria, 14 % in Germany, 13 % in Finland and 11 % in Belgium, to 9 % in the Netherlands, 6 % in the Czech Republic and 4 % in England and Wales [27].…”

Section: Discussionsupporting

confidence: 69%

“…[4]. Low education has consistently been associated with HSV-2 seropositivity [24, 28, 32, 37], and smoking has been reported as a risk factor for HSV-2 infection in some studies [28, 34], but not others [24, 37]. For both sexes, we also found such associations, but it did not reach the level of statistical significance in the multivariable analyses, although close for smoking in women.…”

Section: Discussioncontrasting

confidence: 54%

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Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

et al. 2016

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BackgroundHerpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcer disease (GUD) worldwide. Mother to child transmission causes high morbidity and mortality among infants. Russia is on the brink of a generalized HIV-epidemic, but Arkhangelsk is still a low-prevalence area. HSV-2 infection is associated with a three-fold increased risk of HIV-infection. The evidence on the seroprevalence of HSV-2 in Russia is limited. The aim of this study was to assess HSV-2 seroprevalence and correlates among young adults in the city of Arkhangelsk.Methods1243 adults aged 18-39 years participated in a cross-sectional population-based study, recruited by a public opinion agency applying a quota sampling method to achieve a data set with similar age- and sex-distribution as the population in Arkhangelsk. All participants completed a standardized, self-administrated questionnaire and were tested for HSV-2. Associations between HSV-2 seropositivity and selected sociodemographic and behavioral factors, and self-reported history of sexually transmitted infections (STIs) were studied by multivariable logistic regression.ResultsHSV-2 seroprevalence was 18.8 %: 12.2 % (95 % confidence interval, CI 9.7-15.2) among men and 24.0 % (95 % CI 20.1-27.3) among women. Among men, HSV-2 positivity was associated with being divorced/widowed (OR = 2.85, 95 % CI 1.06-7.70), cohabitation (OR = 2.45, 95 % CI 1.07-5.62), and a history of STIs (OR = 2.11, 95 % CI 1.14-3.91). In women, HSV-2 positivity was associated with high income (OR = 3.11, 95 % CI 1.45-6.71) and having a lifetime number of sexual partners between 2 and 5 (OR = 2.72, 95 % CI 1.14-6.51), whereas sexual debut at age 18 years or older was inversely associated with the outcome (OR = 0.47, 95 % CI 0.31-0.72). In both sexes, increasing age was the strongest correlate of HSV-2 seropositivity in multivariable analyses.ConclusionThe HSV-2 seroprevalence was twice as high in women than in men and increased with age in both sexes, and similar to that reported from high-prevalence countries in Europe and the USA. The high prevalence of HSV-2 among women in childbearing age reveals the potential for HSV-2 transmission from mothers to infants and increased risk of acquisition HIV-infection; it also contributes to the burden GUD among both sexes. This emphasizes the public health implications of the HSV-2 epidemic in an urban population in North-West Russia.

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Section: Discussionsupporting

confidence: 69%

Section: Discussioncontrasting

confidence: 54%

Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

et al. 2016

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“…[10] Studies have found that women are more susceptible to Herpes progenitalis infection biologically. [11,12] Transmission of the virus from male-to-female was more common than from female-to-male. Moreover, the female genitalia have plenty of soft tissue that is exposed for skin contact, which was presumably more receptive to any virus or sexually transmitted disease.…”

Section: Discussionmentioning

confidence: 99%

Genital Herpes: A Possible Clinical Marker of Hiv

Dhanyasree¹,

Ajaykumar²,

Padmaja³

et al. 2016

jemds

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“…30 Studies have found that women are more susceptible to HSV-2 infection biologically. 31,32 Transmission of the virus from male to female is more likely than female to male. Moreover, the female genitalia have plenty of soft tissue that is exposed for skin contact, which is presumably more receptive to any virus or STD.…”

Section: Discussionmentioning

confidence: 99%

Herpes simplex virus 2 infection in HIV seropositive individuals in Tamil Nadu, India

Jacob

Gopal

Kanagasabai

et al. 2015

Int J Community Med Public Health

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Type-specific herpes simplex virus-1 and herpes simplex virus-2 seroprevalence in Romania: comparison of prevalence and risk factors in women and men

Abstract: In Romania, HSV-2 seroprevalence was higher in women than men, and was within European limits and lower than that in Africa and the USA. In contrast, HSV-1 seroprevalence was generally higher than that previously recorded in similarly aged populations in Western Europe.

Cited by 18 publications

References 19 publications

Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

Genital Herpes: A Possible Clinical Marker of Hiv

Herpes simplex virus 2 infection in HIV seropositive individuals in Tamil Nadu, India

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