Type-specific Antigen of Streptococcus rattus Strains (KAY1, FA1 and BHT)

Ota, Fusao; Minato, Yoshihiro; Senesi, Sonia; Nagamune, Hideaki; Satomi, Yasuhiko; Kato, Hirohisa; Akiyama, Yasuyuki; Ono, Miwako; Hirota, Kaoru; Fukui, Komei

doi:10.1016/s0934-8840(89)80066-0

Cited by 2 publications

(1 citation statement)

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“…One possible candidate is cell‐wall‐attached TA. The type‐specific cell wall polysaccharides of Streptococcus rattus are present over the entire outer surface of the cell (Ota et al , 1989) and are serologically distinct from those of the closely related Streptococcus mutans (Pritchard & Rener, 1991), which may explain the observed species difference in zoocin A binding. Treatment of cells with trichloroacetic acid is reported to remove peptidoglycan‐associated cell‐wall polymers from Gram‐positive bacteria (Gopal & Reilly, 1995) and zoocin A did bind to trichloroacetic acid treated Streptococcus rattus peptidoglycan substrates.…”

Section: Resultsmentioning

confidence: 99%

Targeting of streptococci by zoocin A

Åkesson

Dufour

Sloan

et al. 2007

FEMS Microbiology Letters

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Zoocin A is a domain-structured peptidoglycan hydrolase produced by Streptococcus equi ssp. zooepidemicus 4881. [(14)C]-zoocin A was used to measure the amount of zoocin A bound to the surface of cells and to purified peptidoglycan. The sensitivity of various streptococci to zoocin A correlated with the amount of zoocin A bound (R(2)=0.8609). Peptidoglycan purified from Streptococcus oralis and Streptococcus rattus were able to bind zoocin A but remained resistant to hydrolysis. All Streptococcus pyogenes strains were extremely sensitive to zoocin A with minimum inhibition concentrations of 31.5 ng mL(-1) or less, suggesting that zoocin A may have potential for use as an enzybiotic.

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Section: Resultsmentioning

confidence: 99%