Type of surgical treatment and recurrence of oral leukoplakia: 
A retrospective clinical study

Monteiro, Luís Silva; Barbieri, Cinzia; Warnakulasuriya, Saman; Martins, Marco; Salazar, Filomena; Pacheco, José Júlio; Vescovi, Paolo; Meleti, Marco

doi:10.4317/medoral.21645

Cited by 22 publications

(34 citation statements)

References 30 publications

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“…For patients with moderate or severe dysplasia, surgical excision is mandatory. In a European study, excision using a neodymium:yttrium aluminium garnet laser was shown to be effective for oral leukoplakia, and authors in China have recently reported similar findings for erythroplakia . The latter study reported a recurrence rate of 16.7% over 46 months (mean follow‐up).…”

Section: Potentially Malignant Oral Disordersmentioning

confidence: 81%

White, red, and mixed lesions of oral mucosa: A clinicopathologic approach to diagnosis

Warnakulasuriya

2019

Periodontology 2000

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A wide range of conditions could present as persistent white or red, or mixed white and red patches on the oral mucosa. Discussed here are some common conditions encountered in clinical practice that appear as white or red patches, together with some rare, but clinically significant, conditions. Based on pathognomonic features, major diagnostic criteria are outlined to help with the differential diagnosis, while some require further investigation (eg, biopsy and/or microbiologic or hematologic investigation) to confirm the provisional clinical diagnosis. Two conditions that require special consideration are leukoplakia and erythroplakia, as they have the potential to transform to cancer.

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Section: Potentially Malignant Oral Disordersmentioning

confidence: 81%

White, red, and mixed lesions of oral mucosa: A clinicopathologic approach to diagnosis

Warnakulasuriya

2019

Periodontology 2000

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“…In our previous study on 114 patients with OLK treated by CO 2 laser, tobacco use and betel nut chewing were factors related to postoperative recurrence [23]. However, in other studies, alcohol drinking and cigarette smoking were not factors associated with recurrence of OLK [36][37][38]. As for the role of oral habits in the development of Four pieces of missing data in the group of metformin taken (n = 140)…”

Section: Discussionmentioning

confidence: 93%

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

et al. 2021

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Objectives The tongue is identified as a high-risk site for oral leukoplakia and malignant transformation. The purpose of this study is to investigate the clinicopathological characteristics and treatment outcomes of tongue leukoplakia and assess the factors related to recurrence and malignant transformation. Materials and methods One hundred and forty-four patients who received carbon dioxide laser surgery for tongue leukoplakia from 2002 to 2019 were analyzed statistically. Results The follow-up period was 54.90 ± 54.41 months. Thirty patients showed postoperative recurrence (20.83%), and 12 patients developed malignant transformation (8.33%). The annual transformation rate was 2.28%. Univariate analysis showed that a history of head and neck cancer, size of lesion area, clinical appearance, and pathology were significant factors for both recurrence and malignant transformation. In the multivariate logistic regression, a history of head and neck cancer and size of lesion area were independent prognostic factors for recurrence, and a history of head and neck cancer was the only independent factor for postoperative malignant change. Conclusions Clinicians should adopt more aggressive strategies for tongue leukoplakia patients with a history of head and neck cancer. Clinical relevance These results may help clinicians gain a better understanding of oral tongue leukoplakia.

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“…Monteiro et al also reported that diode laser reduced recurrence and malignant transformation of oral leukoplakia [33].…”

Section: Discussionmentioning

confidence: 93%

A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser

et al. 2020

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Oral granular cell tumor (GCT) is a relatively rare, benign lesion that can easily be misdiagnosed. Particularly, the presence of pseudoepitheliomatous hyperplasia might, in some cases, lead to the hypothesis of squamous cell carcinoma. Surgical excision is the treatment of choice. Recurrence has been reported in up to 15% of cases treated with conventional surgery. Here, we reported a case of GCT of the tongue in a young female patient, which was successfully treated through 445 nm diode laser excision. Laser surgery might reduce bleeding and postoperative pain and may be associated with more rapid healing. Particularly, the vaporization effect on remnant tissues could eliminate GCT cells on the surgical bed, thus hypothetically leading to a lower rate of recurrence. In the present case, complete healing occurred in 1 week, and no recurrence was observed after 6 months. Laser surgery also allows the possibility to obtain second intention healing. Possible laser-induced histopathological artifacts should be carefully considered.

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Type of surgical treatment and recurrence of oral leukoplakia: A retrospective clinical study

Cited by 22 publications

References 30 publications

White, red, and mixed lesions of oral mucosa: A clinicopathologic approach to diagnosis

White, red, and mixed lesions of oral mucosa: A clinicopathologic approach to diagnosis

Oral tongue leukoplakia: analysis of clinicopathological characteristics, treatment outcomes, and factors related to recurrence and malignant transformation

A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser

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