Type IV P-Type ATPases: Recent Updates in Cancer Development, Progression, and Treatment
Eugenia M. Yazlovitskaya,
Todd R. Graham
Abstract:Adaptations of cancer cells for survival are remarkable. One of the most significant properties of cancer cells to prevent the immune system response and resist chemotherapy is the altered lipid metabolism and resulting irregular cell membrane composition. The phospholipid distribution in the plasma membrane of normal animal cells is distinctly asymmetric. Lipid flippases are a family of enzymes regulating membrane asymmetry, and the main class of flippases are type IV P-type ATPases (P4-ATPases). Alteration i… Show more
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