Type IV Collagen, Type IV Collagenase Activity and Ability of Cell Proliferation in Human Thyroid Tumours

Kusunoki, Takeshi; Nishida, Shozo; Kimoto-Kinoshita, Saori; Murata, Kiyotaka; Satou, Takao; Tomura, Takanori

doi:10.1016/s1015-9584(09)60196-2

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…We believe that the following hypothesis explains why HTTs show this characteristic von Kossa staining pattern. It has been already demonstrated by immunostaining that collagen type IV is abundantly present in the stroma of HTT . The stroma of HTTs was positive for collagen type IV immunostaining in this study.…”

Section: Discussionsupporting

confidence: 78%

“…Kossa positivity seemed to be observed especially around small vessels in HTT stroma. Immunostaining for type IV collagen reveals that there is a basement membranous constituent in HTT stroma, because type IV collagen is a component of the basement membrane and HTT stroma has been reported to be composed of type IV collagen . Kossa‐positive abundant tiny black dots were distributed in the basement membranous component.…”

Section: Discussionmentioning

confidence: 97%

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Stromal tiny black dots, like “sugar‐coated”, of von Kossa stain is a diagnostic clue to hyalinizing trabecular tumor of the thyroid gland

Hino

Motoi

Toda

et al. 2018

Pathology International

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Hyalinizing trabecular tumor (HTT) is a rare low-grade tumor, and a prominent feature is the basement membranous stroma. We assume that such characteristic stromal findings of HTT are related to calcium deposition, and examined HTT samples by von Kossa special staining. There has been no report describing von Kossa special staining for such stroma. We collected 12 cases of HTT and 30 cases of papillary thyroid carcinoma (PTC) that had matched age, gender, tumor size, and surgical procedure characteristics as a control group. We compared the staining pattern and degree of von Kossa positivity between HTT and PTC, and a grading system of von Kossa stain was adopted to highlight differences between them. On von Kossa staining, all HTT revealed many tiny black dots around vessels in the hyalinized stroma, like "sugar-coated", and a high degree of calcium deposition in most cases, whereas PTC showed sparse stromal calcification in some cases. The degree of von Kossa staining was significantly different between the two groups. This is the first report describing abundant tiny black dots, like a "sugar-coated" appearance, of von Kossa stain in HTT. Here, we propose this finding can be a useful diagnostic clue to HTT.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 97%

Stromal tiny black dots, like “sugar‐coated”, of von Kossa stain is a diagnostic clue to hyalinizing trabecular tumor of the thyroid gland

Hino

Motoi

Toda

et al. 2018

Pathology International

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“…The activity of base membrane COL4 indicates the cell proliferation and metastatic abilities of thyroid cancer (46). Kusunoki et al (47) showed that the level of COL4 collagenase in patients with thyroid cancer was higher, compared with that in the normal thyroid, and COL4 may assist in predicting the invasion and metastasis of thyroid cancer. The expression of COL5A1 is suppressed by microRNA-145 in anaplastic meningionas (48).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile

Huang

Tao

et al. 2016

Oncology Letters

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Anaplastic thyroid carcinoma (ATC) is an aggressive malignant disease in older adults with a high mortality rate. The present study aimed to examine several key genes and pathways, which are associated with ATC. The GSE33630 gene expression profile was downloaded from the Gene Expression Omnibus database, which included 11 ATC and 45 normal thyroid samples. The differentially expressed genes (DEGs) in ATC were identified using the Limma package in R. The Gene Ontology functions and Kyoto Encyclopedia of Genes and Genomes pathways of the selected DEGs were enriched using the Database for Annotation, Visualization and Integrated Discovery. A protein-protein interaction (PPI) network of the DEGs was constructed to select significant modules. Furthermore, a latent pathway interactive network was constructed to select the significant pathways associated with ATC. A total of 665 DEGs in the ATC samples were screened, and four significant modules were selected from the PPI network. The DEGs in the four modules were enriched in several functions and pathways. In addition, 29 significant pathways associated with ATC were selected, and he Toll-like receptor (TLR) signaling pathway, extracellular matrix (ECM)-receptor interaction and cytokine-cytokine interaction pathway were identified as important pathways. FBJ murine osteosarcoma viral oncogene homolog (FOS), chemokine C-X-C motif ligand 10 (CXCL10), collagen type V α1 (COL5A1) and chemokine (C-C motif) ligand 28 (CCL28) were the key DEGs involved in these significant pathways. The data obtained in the present study revealed that the TLR signaling pathway, ECM-receptor interaction and cytokine-cytokine receptor interaction pathway, and the FOS, CXCL10, COL5A1, COL11A1 and CCL28 genes have different roles in the progression of ATC, and these may be used as therapeutic targets for ATC.

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“…Multiple enzymes are involved in basement membrane degradation including the matrix metalloproteinases (MMPs), a group of nine Zn +2 ‐dependent endopeptidases. The main component of basement membrane architecture is type 4 collagen, making MMP‐2 and MMP‐9 the main foci in the study of basement membrane degradation 18 . MMPs are balanced by the tissue inhibitors of MMPs, which act to prevent MMP protein digestion.…”

Section: Biologies Of Invasionmentioning

confidence: 99%

“…The main component of basement membrane architecture is type 4 collagen, making MMP-2 and MMP-9 the main foci in the study of basement membrane degradation. 18 MMPs are balanced by the tissue inhibitors of MMPs, which act to prevent MMP protein digestion.…”

Section: Basement Membrane Disruptionmentioning

confidence: 99%

Aerodigestive Tract Invasion by Well‐Differentiated Thyroid Carcinoma: Diagnosis, Management, Prognosis, and Biology

McCaffrey¹

2006

The Laryngoscope

107

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Basic science: there is a decrease in membrane expression of E-cadherin in IWDTC, and loss of this tumor suppressor adhesion molecule may contribute to the invasive nature of well-differentiated thyroid carcinomas. Clinical: laryngotracheal invasion is a significant independent prognostic factor for survival. Patients undergoing shave excision had similar survival when compared with those undergoing radical tumor resection if gross tumor did not remain. Gross intraluminal tumor should be resected completely. Shave excision is adequate for minimal invasion not involving the intraluminal surfaces of the aerodigestive tract.

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Type IV Collagen, Type IV Collagenase Activity and Ability of Cell Proliferation in Human Thyroid Tumours

Abstract: These findings suggest that staining for type IV collagen and type IV collagenase activity reflect the ability of cell proliferation, and help predict the aggressiveness of invasion and metastasis in human thyroid tumours.

Cited by 5 publications

References 6 publications

Stromal tiny black dots, like “sugar‐coated”, of von Kossa stain is a diagnostic clue to hyalinizing trabecular tumor of the thyroid gland

Stromal tiny black dots, like “sugar‐coated”, of von Kossa stain is a diagnostic clue to hyalinizing trabecular tumor of the thyroid gland

Bioinformatics analysis of key genes and latent pathway interactions based on the anaplastic thyroid carcinoma gene expression profile

Aerodigestive Tract Invasion by Well‐Differentiated Thyroid Carcinoma: Diagnosis, Management, Prognosis, and Biology

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