Type III von Willebrand's disease in Dutch kooiker dogs

Slappendel, R.J.; Beijer, Els; Leeuwen, Martin van

doi:10.1080/01652176.1998.9694847

Cited by 18 publications

(27 citation statements)

References 22 publications

(10 reference statements)

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“…This observation differs from previous reports, wherein binding of FVIII to vWF prolonged the half-life of FVIII in the circulation, and decreased vWF concentration was associated with decreased FVIII activity. 17,29,34 However, other researchers state that aPTT can be within the reference intervals in vWD-affected dogs. 18 In a previous study, all vWDaffected dogs had reduced FVIII activity, but not to the same degree as the decrease in vWF:Ag and not severe enough to prolong the aPTT.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Von Willebrand Disease in Dogs from São Paulo State, Brazil

et al. 2010

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Abstract. The aims of the current study were to assess the prevalence of von Willebrand disease (vWD) in dogs from the region of Botucatu, Sã o Paulo State, Brazil, and to evaluate laboratory tests to diagnose this disease. The study included 350 dogs of various ages, different breeds, and both sexes. Dogs included in the study had no historical or clinical evidence of abnormal bleeding. von Willebrand factor antigen (vWF:Ag), buccal mucosal bleeding time, activated partial thromboplastin time, and factor VIII activity were evaluated in their ability to diagnose vWD. The prevalence of vWD in dogs was 1.43% in the Botucatu region of Brazil. Determination of vWF:Ag was the best laboratory test to diagnose vWD.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Von Willebrand Disease in Dogs from São Paulo State, Brazil

et al. 2010

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“…Additionally, Brooks et al [11] reported that a single vWF: Ag levels can be applied breeding dogs selection without vWD in German Wirehaired Pointers. However, Slappendel et al [22] speculated that plasma vWF: Ag levels ranged between 30 to 89% in 39 Dutch kookier dogs are obligate carriers of Type III vWD. In addition, in people for the estimates of the heritability is used as plasma vWF: Ag levels in between 35-75% [16] .…”

Section: Discussionmentioning

confidence: 99%

“…In German Wirehaired Pointers; carrier ratio reported to be 12% and disease developing ratio is reported to be 1% [11] . On the other hand, Dutch Kookier dogs this ratio determined to be 5.2% (in 717 dogs; 38 dogs had type III vWD) [22] . According to Brooks et al [19] when lower than 50% vWF: Ag concentration taken into consideration; 73% of dobermans, 30% of scotties, and 28% of shelties had abnormal vWF: Ag concentration.…”

Section: Discussionmentioning

confidence: 99%

“…As a result of the present study; relationship between MspI cutting region and vWF: Ag levels could not be determined. The reason could be; investigated each breed a vWD; the levels of vWF: Ag were different levels as reported by Slappendel et al [22] , or it was thought that the number of animals that diagnosed as vWD were too low. Furthermore, in the present study it was believed that, MspI region that used genotyping of dog breeds could not be effective in determining individuals having mutant allele.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study no correlation between the occurrence of the vWD, sex or age in dogs also determined. In vWD dogs; number of platelet, TT, PT, APTT times were reported to be in generally reference values or APTT time were slightly a bit longer than normal [2,12,14,22] . Similarly, in the present study, platelet number, TT, PT and APTT times were in reference borders and differences between two groups were not significant.…”

Section: Discussionmentioning

confidence: 99%

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Köpeklerde von Willebrand Faktör Antijen Seviyesi ve von Willebrand Faktör Geni Arasındaki İlişkinin Belirlenmesi

Aslan¹,

Arslan²,

Keleş³

et al. 2016

Kafkas Univ Vet Fak Derg

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In this study, the relationship between plasma vWF antigen level and polymorphism occurring due to the leucine (L) to proline (P) substitution at position 2380 in exon 42 in von Willebrand factor gene (VWF) in dogs was aimed to investigate. The present study was performed on 161 dogs of various breeds and ages (95 male, 66 female) referred to Faculty of Veterinary Clinics at Erciyes University between January 2014 and 2015. Blood samples were collected in EDTA and Na citrate tubes after clinical examination of the dogs. PT, APTT, TT, fibrinogen, D-dimer, thrombocyte, vWF antigen (vWF: Ag) levels and VWF were determined from the blood samples. Genotypes were examined using PCR and restriction endonucleas enzymes. In the laboratory examination, 34 (21.1%) of the cases were positive and 127 (78.9%) of the cases were negative with concern to von Willebrand. Prevalence of the disease in different dog breeds that included to the present study were Golden Retreiver (n=35) 34.3%, Kangal (n=45) 11.1%, German Shepherd (n=11) 36.4%, Labrador Retriever (n=7) 42.9%, English Cocker Spaniel (n=2) 100%, English Pointer (n=8) 25.0%, mix breed (n=8) 33.3%, Husky (n=7) 12.5%, Malinois (n=1) 100%, Dogo Argentino (n=2) 50.0%, Samoyed (n=1) 100% and some other breeds were 0%. The genotype of VWF was not statistically significant in both positive and negative dogs with concern to vWF: Ag values (P=0.675). When comparison were made in terms of proportional distribution in positive and negative dogs, statistical importance were not observed between genotype and the disease ratio (P=0.969). In conclusion, relationship between VWF and vWF antigen level were not determined in dogs. According to our knowledge; this study is the first repot on VWF and vWF: Ag relationship therefore believed to be important. Keywords: Coagulation, Dog, Haemostasis, Mutation, von Willebrand factor Köpeklerde von Willebrand Faktör Antijen Seviyesi ve von Willebrand Faktör Geni Arasındaki İlişkinin Belirlenmesi ÖzetBu çalışmada, köpeklerde von Willebrand faktör geninin 42. ekzonunun 2380. pozisyonunda meydana gelen lösin (L) -prolin (P)'nin yer değiştirmesine neden olan mutasyon sonucu oluşan polimorfizm ile plazma vWF antijen seviyeleri arasındaki ilişkinin araştırılması amaçlandı. Çalışmaya, Ocak 2014 ve 2015 yılları arasında, Erciyes Üniversitesi Veteriner Fakültesi Kliniklerine getirilen farklı ırk ve yaşta (95 erkek, 66 dişi) 161 köpek dahil edildi. Köpeklerin klinik muayeneleri yapılarak EDTA ve Na sitratlı tüplere kan örnekleri toplandı. Kan örneklerinde PT, APTT, TT, fibrinojen, D-dimer, trombosit, vWF antigen (vWF: Ag) seviyeleri belirlendi ve VWF elde edildi. Genotipler, yapılan PCR sonucunda elde edilen ürünlerin MspI endonükleaz enzimi ile kesilerek belirlendi. Laboratuar muayenesinde 34 köpek (%21.1) von Willebrand açısından pozitif olarak belirlenirken, 127 köpeğin (%78.9) negatif olduğu belirlendi. Çalışmaya dahil edilen hayvanlarda ırklara göre hastalığın görülme oranları Golden Retreiver (n=35) %34.3, Kangal (n=45) %11.1, German Shepherd...

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2018

Breed Predispositions to Disease in Dogs and Cats

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Type III von Willebrand's disease in Dutch kooiker dogs

Cited by 18 publications

References 22 publications

Prevalence of Von Willebrand Disease in Dogs from São Paulo State, Brazil

Prevalence of Von Willebrand Disease in Dogs from São Paulo State, Brazil

Köpeklerde von Willebrand Faktör Antijen Seviyesi ve von Willebrand Faktör Geni Arasındaki İlişkinin Belirlenmesi

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