Type III Secretion System Genes in Clinical
            <i>Aeromonas</i>
            Isolates

Chacón, Matilde R.; Soler, L.; Groisman, Eduardo A.; Guarro, Josep; Figueras, María José

doi:10.1128/jcm.42.3.1285-1287.2004

Cited by 74 publications

(37 citation statements)

References 32 publications

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“…Whereas the alt gene was mainly detected in strains from diarrhoea, theaexT and ascV genes were basically found among environmental strains. In contrast, a high proportion of aexT and ascV genes amongst intestinal and extraintestinal strains, has been found [40].…”

Section: Discussionmentioning

confidence: 89%

Aeromonas hydrophilaclinical and environmental ecotypes as revealed by genetic diversity and virulence genes

Aguilera‐Arreola

Hernández-Rodríguez

Zúñiga

et al. 2005

FEMS Microbiology Letters

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Aeromonas hydrophila strains recovered from clinical samples and ambient sources were phenotypically and genetically identified. In addition, the distribution of putative virulence factors was assayed. To determine the genetic diversity of these strains, random amplification of polymorphic DNA (RAPD) and enterobacterial repetitive intergenic consensus (ERIC)-PCR markers were used. The discriminatory ability of the techniques, using Simpson's index, was 0.96 for both methods. The most consistent dendrogram was obtained when RAPD and ERIC data were combined. The genetic diversity revealed a high intra-specific genetic diversity (h=0.364+/-0.024 and I=0.538+/-0.030). The strains showed a tendency to cluster according to their origin of isolation (best-cut test 0.80 and bootstrap values >50%). The present study demonstrates and quantifies the high intra-specific diversity within this species and reveals a clear differentiation of strains according to their ecological origin. The distribution of virulence-related genes confirm that A. hydrophila is a genetically heterogeneous species that harbour ecotypes which have different pathogenic potential to human and other animals.

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Section: Discussionmentioning

confidence: 89%

Aeromonas hydrophilaclinical and environmental ecotypes as revealed by genetic diversity and virulence genes

Aguilera‐Arreola

Hernández-Rodríguez

Zúñiga

et al. 2005

FEMS Microbiology Letters

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“…Homologues of genes associated with a type III secretion system (T3SS) have been identified in the aeromonads, including both clinical and environmental isolates. 17,18 The T3SS is commonly associated with pathogenesis and virulence, and is required for the injection of bacterial proteins in to eukaryotic cells. In A. hydrophila AH-3 the construction of an insertion mutant of the TTSS gene ascV resulted in reduced toxicity and virulence in comparison with the wild-type strain.…”

Section: Microbiologymentioning

confidence: 99%

Aeromonas spp. clinical microbiology and disease

Parker¹,

Shaw²

2011

Journal of Infection

326

255

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“…Aeromonas, as many other recognized patho-genic microbes, displays a variety of virulence determinants involved in the infection process, namely, colonization, invasion and proliferation, showing the ability to damage host tissues as well as to evade the host defence system [3,4]. The recent discovery of the existence of a type III secretion system (TTSS) in Aeromonas [5,6], shows that it is equipped with the same genetic machinery to deliver toxin directly into the hosts as primary pathogens such as Salmonella enterica, Yersinia spp., enteropathogenic Escherichia coli, etc. TTSS genes are prevalent in clinical strains of A. veronii, A. hydrophila and A. caviae, explaining why these are the prevalent species involved in human disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical relevance of Aeromonas sM503

Figueras¹

2005

Reviews in Medical Microbiology

118

137

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More than 100 published cases of Aeromonas infection over the last 6 years have involved both healthy and immunocompromised patients. The spectrum of clinical presentations is in line with those previously reported, namely, gastroenteritis, haemolytic uremic syndrome, urine, wound and burn infections, infections associated with leech therapy, necrotizing fasciitis, pneumonia, meningitis and eye infections. Despite that, new syndromes including intravascular gas production, epididymitis and pyelonephritis have also been reported. New data seem to indicate an increasing tendency to affect patients with hepatobiliary disease, especially those with cirrhosis, culminating in a rapid and fatal outcome. As it has traditionally been the case, A. hydrophila was still the most frequently reported species although it is not the only or most frequent species in reality. The false importance attributed to this species is due to limitations in the identification methods for other pathogenic species. Unfortunately, awareness or suspicion of the involvement of Aeromonas in the spectrum of clinical presentations reviewed is still insufficient for the correct management of the infection. ß 2005 Lippincott Williams & Wilkins Reviews in Medical Microbiology 2005, 16:145-153

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Type III Secretion System Genes in Clinical Aeromonas Isolates

Cited by 74 publications

References 32 publications

Aeromonas hydrophilaclinical and environmental ecotypes as revealed by genetic diversity and virulence genes

Aeromonas hydrophilaclinical and environmental ecotypes as revealed by genetic diversity and virulence genes

Aeromonas spp. clinical microbiology and disease

Clinical relevance of Aeromonas sM503

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