Type III procollagen is the major collageneous component produced by a continuous rhabdomyosarcoma cell line

Krieg, Thomas; Timpl, Rupert; Alitalo, Kari; Kurkinen, Markku; Vaheri, Antti

doi:10.1016/0014-5793(79)80863-7

Cited by 56 publications

(24 citation statements)

References 26 publications

(6 reference statements)

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“…Alternatively, it could have a stromal cell origin, thus aiding the host by walling off the invading tumor . This is in accordance with cell line studies published in the literature …”

Section: Discussionsupporting

confidence: 93%

“…Kreig et al . proposed that a continuous cell line derived from human embryonal rhabdomyosarcoma synthesizes mainly type III procollagen with a small amount of type IV.…”

Section: Discussionmentioning

confidence: 99%

“…25 Studies on osteosarcomas have also found the presence of both types I and III collagen in the fibroblastic areas of tumors: type III in anaplastic areas and type II in chondroblastic areas of osteosarcomas. 27 Kreig et al 28 proposed that a continuous cell line derived from human embryonal rhabdomyosarcoma synthesizes mainly type III procollagen with a small amount of type IV. Similarly, in his study of collagen III in ovarian tumors, Stenbäck demonstrated that the propeptide type III procollagen positive stromal meshwork that surrounded individual cells in thecomas was absent in diffuse granulosa cell tumors and distinctly developed in malignant stromal neoplasms.…”

Section: Junqueiramentioning

confidence: 99%

“…10 This is in accordance with cell line studies published in the literature. 28,31,32 The behavior of OSCC indicates that neoplastic growth requires a functional stroma. The ability of neoplastic cells to induce the formation of such a stroma is of great importance.…”

Section: Junqueiramentioning

confidence: 99%

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Expression of type III collagen correlates with poor prognosis in oral squamous cell carcinoma

Kumari

Ghosh

Patil

et al. 2016

J of Invest & Clin Dent

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“…Alternatively, it could have a stromal cell origin, thus aiding the host by walling off the invading tumor . This is in accordance with cell line studies published in the literature …”

Section: Discussionsupporting

confidence: 93%

“…Kreig et al . proposed that a continuous cell line derived from human embryonal rhabdomyosarcoma synthesizes mainly type III procollagen with a small amount of type IV.…”

Section: Discussionmentioning

confidence: 99%

Section: Junqueiramentioning

confidence: 99%

Section: Junqueiramentioning

confidence: 99%

See 2 more Smart Citations

Expression of type III collagen correlates with poor prognosis in oral squamous cell carcinoma

Kumari

Ghosh

Patil

et al. 2016

J of Invest & Clin Dent

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show abstract

“…14 and unpublished data). The possibility that type IV procollagen sequences might also be represented in these libraries was explored, since type IV is synthesized by the CCL136 cell line (18) as well as by a fibroblast culture (GM2962) from an osteogenesis imperfecta patient (19).…”

Section: Resultsmentioning

confidence: 99%

Restricted homology between human alpha 1 type IV and other procollagen chains.

Brinker¹,

Gudas²,

Loidl³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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Screening of a human fibroblast cDNA library with a mouse type IV procollagen done resulted in one 1.05-kilobase isolate that was used to identify a 1.7-kilobase clone overlapping the former by <150 nucleotides. EcoRl digestion revealed that the larger clone exhibited the pattern characteristic of DNA coding for a collagenous sequence. Blot hybridization to RNA from mouse F9 stem cells and from these cells treated with retinoic acid and N',02'-dibutyryl-cAMP

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Extracellular matrix proteins characterize human tumor cell lines

Alitalo

Keski‐Oja

Vaheri

1981

Intl Journal of Cancer

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Extracellular matrix proteins synthesized and secreted by adherent human tumor cell lines were analyzed using metabolic labelling with glycine and proline in the presence of ascorbate, polypeptide analysis and polyacrylamide gel electrophoresis, affinity chromatography, collagenase digestion, and immunofluorescence staining. The results showed a characteristic pattern of matrix proteins for each tumor cell type. Tumor cell lines of mesenchymal origin produced mostly interstitial types (I and II) of collagen and fibronectin. Carcinoma cell lines secreted only basement membrane proteins, type IV collagen, laminin and fibronectin, but not interstitial collagen. A melanoma and a rhabdomyosarcoma cell line produced type V of procollagen that has not previously been described in cell culture. Neuroblastoma cells were shown to be phenotypically heterogeneous also with respect to matrix protein production. We propose that the analysis of extracellular matrix proteins may serve as an adjunct in the classification of human tumors.

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Type III procollagen is the major collageneous component produced by a continuous rhabdomyosarcoma cell line

Cited by 56 publications

References 26 publications

Expression of type III collagen correlates with poor prognosis in oral squamous cell carcinoma

Expression of type III collagen correlates with poor prognosis in oral squamous cell carcinoma

Restricted homology between human alpha 1 type IV and other procollagen chains.

Extracellular matrix proteins characterize human tumor cell lines

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