Type III Mixed Cryoglobulinemia Associated with Digital Necrotic Ulcer Successfully Treated with Intermittent Intravenous Pulse Cyclophosphamide

Çakır, Ömer; Ayyıldız, Orhan; Işıkdoğan, Abdurrahman

doi:10.1177/000331970505600418

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…(2005) have reported a case of type 3 mixed cryoglobulinemia with digital necrosis which was successfully treated with intermittent IV pulse cyclophosphomide. [9] The reported case was successfully treated with broad-spectrum antibiotics, anticoagulants, and systemic steroids.…”

Section: Discussionmentioning

confidence: 99%

Cryoglobulinemia in a child

Rao

2010

Indian J Dermatol

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Cryoglobulinemia is a rare condition. We report a case of cryoglobulinemia in 1.5-year-old boy, who presented with bluish black discoloration of hands and feet. Serum was positive for cryoglobulins. The serum cryoglobulin level was 70 μg/ml (normal <20 μg). Serum protein electrophoresis revealed the presence of M-spike. Serum immunofixation and assessment of clonality could not be done as these specialized investigations are not available here. Investigations did not reveal any systemic involvement. He was treated with anticoagulants, broad-spectrum antibiotics, and systemic steroids with which he recovered completely.

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Section: Discussionmentioning

confidence: 99%

Cryoglobulinemia in a child

Rao

2010

Indian J Dermatol

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“…Se debe realizar enfásis en las manifestaciones cutáneas de la crioglobulinemia mixta, dado que son síntomas típicos descritos la presencia de púrpura ortostática intermitente hasta lesiones úlcerosas en piernas y especialmente en área maleolar con cambios de coloración ocre en dichas áreas (5,6). Estos hallazgos son evidentes en las imágenes previamente expuestas en el artículo.…”

Section: Reporte De Casounclassified

Crioglobulinemia esencial como causa de hemorragia alveolar - reporte de caso y revisión de la literatura

et al. 2015

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ResumenPresentamos el caso de una paciente quien ingresa por la presencia de lesiones petequiales, artralgias y una úlcera en miembro inferior. La presencia de azoados en ascenso progresivo se documenta durante su estancia. Se instaura manejo con corticoide IV sin respuesta y se obtienen mejoría con plasmaféresis. Posteriormente se observa la presencia de deterioro del patrón respiratorio, disnea sumado a la presencia de compromiso pulmonar en parches por medio de tomografía de tórax y con evidencia de hemorragia alveolar. Se descartan causas autoinmunes e infecciosas, así como neoplasias hematológicas. Se concluye que la presencia de crioglobulinemia es la única causa de dicha entidad.Palabras clave: Crioglobulinas, hemorragia alveolar, insuficiencia renal, disnea, autoinmunidad. AbstractWe report the case of a patient who is admitted by the presence of petechial lesions, arthralgia and an ulcer in lower limb. The presence of progressively increasing creatinine is documented while staying. Unanswered management with corticosteroid IV was instituted and there was an improvement with plasmapheresis. Later, the presence of impaired breathing pattern was notice, dyspnea combined with the presence of lung involvement in patches through chest tomography and evidence of alveolar hemorrhage. Autoimmune and infectious causes and hematological malignancies were dismissed. The presence of cryoglobulinemia was identified as the unique cause of such entity.

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Neurologic manifestations associated with cryoglobulinemia: A single center experience

Feldman

Dhamne

2019

Journal of the Neurological Sciences

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Type III Mixed Cryoglobulinemia Associated with Digital Necrotic Ulcer Successfully Treated with Intermittent Intravenous Pulse Cyclophosphamide

Cited by 5 publications

References 4 publications

Cryoglobulinemia in a child

Cryoglobulinemia in a child

Crioglobulinemia esencial como causa de hemorragia alveolar - reporte de caso y revisión de la literatura

Neurologic manifestations associated with cryoglobulinemia: A single center experience

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