Type III collagen is a major component of interodontoblastic fibers of the developing mouse molar root

Ohsaki, Yasuyoshi; Nagata, Kazuhiro

doi:10.1002/ar.1092400303

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…Furthermore, TEM micrographs revealed very weak positive labelling for III‐CF of the forming collagen fibrils throughout the entire pre‐dentine layer, until the mineralization front. This is only partially in accordance with the studies of Ohsaki & Nagata (1994) that showed a strong staining for III‐CF in interodontoblastic fibres of rat molars. In human developing teeth, Lukinmaa et al.…”

Section: Discussionsupporting

confidence: 88%

“…Dentine is first deposited by the odontoblasts as a layer of non-mineralized organic matrix called pre-dentine that lines the innermost pulpal portion and that varies in thickness; however, it remains constant during ageing because the amount that calcifies is balanced by addition of newly-secreted matrix (Nanci 2003). The first sign of pre-dentine formation is the appearance of large-diameter collagen fibrils, called von Korff fibres, that appear at least during radicular circumpulpal dentine formation and mainly consist of type IIIcollagen fibrils (III-CF) (Ohsaki & Nagata 1994, Kitasako et al 2002. Although their existence Correspondence: Prof. Lorenzo Breschi, Division of Dental Sciences and Biomaterials, Department of Biomedicine, University of Trieste, Via Stuparich, 1, 34129 Trieste, Italy (Tel.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical identification of type I and type III collagen and chondroitin sulphate in human pre‐dentine: a correlative FEI‐SEM/TEM study

et al. 2007

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Immunohistochemical identification of type I and type III collagen and chondroitin sulphate in human pre‐dentine: a correlative FEI‐SEM/TEM study

et al. 2007

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“…Type I collagen is found mainly in thick fibrils, whereas type III collagen occurs in thin fibrils in the liver, skin, and tendon (Nowack et al 1976;Fleischmajer et al 1981) and is scattered throughout the tissue of human dental pulp but not as fibrils passing between the odontoblasts (Magloire et al 1982). However, investigations of the developing mouse molar have revealed collagen type III as a major component of interodontoblastic fibers (Shroff and Thomas 1992;Ohsaki and Nagata 1994). Our study has demonstrated the presence of collagen type III in the predentin layer but not as a component of the interodontoblastic fibers of the teeth examined.…”

Section: Discussionmentioning

confidence: 96%

Light-microscopical investigation of the distribution of extracellular matrix molecules and calcifications in human dental pulps of various ages

Hillmann

Geurtsen

1997

Cell and Tissue Research

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The distribution of extracellular matrix molecules, especially collagen types I, III, V, and VI, in the extracellular matrix of the connective tissue of human dental pulp of various ages was studied by polarization and indirect immunofluorescence microscopy by using a conventional fluorescence microscope and a confocal laser scanning microscope. Polarization and immunofluorescence microscopy of paraffin sections showed thick fibers of collagen type I, which represented the main component of the connective tissue matrix of the dental pulp. By indirect immunofluorescence, thin fibers and small bundles of collagen type III were determined to be one of the main fibrillar elements present in the dental pulp matrix. Collagen type IV was detected by a clear intense staining of the basement membrane of blood vessels at all ages examined. Collagens type V and VI formed a dense meshwork of thin microfibrils throughout the stroma of the connective tissue of the dental pulp. These fibers were localized around blood vessels and appeared to be enriched in the subodontoblastic layer. Investigations by means of confocal laser scanning microscopy revealed fibers of collagen type VI spiralling between fully differentiated odontoblasts toward the predentin layer. With advancing age, the connective tissue matrix appeared to be condensed and aggregates of thick fiber bundles could be observed. Furthermore, the participation of various collagen types in the composition of pulp stones was shown. These calcifications and diffuse calcifications increased in frequency with advancing age in a statistically significant manner.

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“…The von Korff fibers have been frequently reported in mantle dentin . These fibers consist of coarse, bundled collagen fibrils of type III, with a minor portion of type I , and run with their long axis parallel to that of the odontoblast processes . Mantle dentin is also different in biochemical composition : for example, it seems to be absent of phosphoproteins .…”

Section: Mantle Dentinmentioning

confidence: 99%

Dentin basic structure and composition—an overview

Tjäderhane¹,

Carrilho²,

Breschi³

et al. 2009

Endodontic Topics

127

104

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Dentin is the most voluminous structural component of human tooth. Dentin protects pulp tissue from microbial and other noxious stimuli. It also provides essential support to enamel and enables highly mineralized and thus fragile enamel to withstand occlusal and masticatory forces without fracturing. Furthermore, it is the first vital tissue to meet external irritation, and instead of being merely a passive mechanical barrier, dentin may in many ways participate in dentin–pulp complex defensive reactions. Even though dentin is usually considered as an entity, different parts of dentin may have special qualitative properties that help dentin to meet all of its required demands. The aim of this review is to provide an overview of the basic structure and composition of dentin, including the collagenous components of the dentin organic matrix and minerals. We also describe the specific structural and functional features of the dentin–enamel junction (DEJ), mantle dentin, inter‐ and peritubular dentin, and pulp stones.

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Type III collagen is a major component of interodontoblastic fibers of the developing mouse molar root

Abstract: This study presents for the first time, immunohistochemical observations which demonstrate the presence of IOF at least during root circumpulpal dentin formation and which reveal that type III collagen is a major component of IOF.

Cited by 13 publications

References 22 publications

Immunohistochemical identification of type I and type III collagen and chondroitin sulphate in human pre‐dentine: a correlative FEI‐SEM/TEM study

Immunohistochemical identification of type I and type III collagen and chondroitin sulphate in human pre‐dentine: a correlative FEI‐SEM/TEM study

Light-microscopical investigation of the distribution of extracellular matrix molecules and calcifications in human dental pulps of various ages

Dentin basic structure and composition—an overview

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