Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

Section: Conclusion These Observations Suggest That T Cell Activatiomentioning

confidence: 99%

Section: Conclusion These Observations Suggest That T Cell Activatiomentioning

confidence: 99%

Suppression of autoimmune arthritis in interleukin‐1‐deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells

Saijo

Asano

Horai

et al. 2002

“…However, DBA/1 mice are sensitive to collageninduced arthritis (CIA), which resembles RA in humans, and they are commonly used experimentally (10). The development of CIA is significantly influenced by the major histocompatibility complex (MHC) Aq gene and, to a lesser extent, by other susceptibility loci.…”

mentioning

confidence: 99%

Accelerating effect of an MRL gene locus on the severity and onset of arthropathy in DBA/1 mice

Oishi¹,

Miyazaki²,

Mizuki³

et al. 2005

Objective. To analyze the influence of the genetic background of an arthritis-prone strain of mice, MRL, on the spontaneous development of arthropathy in DBA/1 mice, which histopathologically resembles enthesopathy in humans, and to clarify the strain-specific gene loci and their interactions that confer susceptibility to arthropathy.Methods. MRL, DBA/1, (MRL ؋ DBA/1)F 1 , and (MRL ؋ DBA/1)F 2 intercross mice were prepared, and the severity and onset of arthropathy of the ankle joints in individual mice were quantified (0-3 and 0-5 scale, respectively). A genome-wide scan of 271 male F 2 intercross mice with polymorphic microsatellite markers was performed.Results. Only male DBA/1, (MRL ؋ DBA/1)F 1 , and (MRL ؋ DBA/1)F 2 mice developed arthropathy. The macroscopic and histopathologic findings of arthropathy in the F 2 mice were similar to those in the parental DBA/1 mice, but the onset was significantly earlier. In the quantitative trait locus analysis of male F 2 mice, 1 susceptibility locus for both the severity and early onset of the disease in the region of an MRL allele, Amd1, was located at marker D10Mit259 (map position 40.0 cM), which was common to 1 of the sialadenitis susceptibility loci in MRL mice, Asm1. Another susceptibility locus for the severity and early onset of arthropathy in the region of a DBA allele, Amd2, was located at D3Mit46 (29.5 cM). These loci manifested an additive effect on the development of arthropathy.Conclusion. Arthropathy in DBA/1 mice is under the control of an allelic combination of gene loci, one of which is common to the locus for sialadenitis in MRL/ MpJ-lpr/lpr mice.

“…Interestingly, the DBA/l mouse appears to be particularly susceptible to both collagen-induced arthritis (7) and oil-induced arthritis (6). This susceptibility appears to be dependent on both sex-linked genes (males being more susceptible than females [S]) and non-sex-linked genes (mainly major histocompatibility complex [MHC] class I1 [6,7]), and there are no reports of any generalized immunologic aberration in this mouse strain.…”

mentioning

confidence: 99%

Characterization of a spontaneously occurring arthritis in male DBA/1 mice

Nordling

Karlsson‐Parra

Jansson

et al. 1992

Objective. We studied the incidence, severity, histopathologic features, and status of infection in a spontaneous polyarthritis which occurs in male DBAll mice.Methods. Over a 25-week period, the arthritis was evaluated macroscopically in naive mice of different strains. The histopathology was evaluated at different phases of the disease. Virologic and bacterioiogic investigations were performed.Results. The arthritis occurs in -80% of aging male DBM1 mice. The disease is chronic and destructive, and the affected joints are characterized by synovial lining proliferation and infiltration of inflammatory cells, mainly mononuclear. The susceptibility appears to be dependent on both sex-linked and nonsex-linked genes, since female DBM1 mice are not From the