1986
DOI: 10.1016/0014-4800(86)90048-1
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Type II cell proliferation related to migration of inflammatory cells into the lung

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Cited by 30 publications
(9 citation statements)
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“…The in situ proliferation of lung macrophages after damage induced by bleomycin and hyperoxia in hamsters (39) as well as an increase in the proportion of proliferating macrophages in chronic lung inflammation in humans (40) have been demonstrated. Conversely, the migration of inflammatory cells through the vasculature into the lung induced proliferation of type II cells in the absence of morphological injury to the lung (41). Studies of the response to intratracheal antigen challenge in mice demonstrated that the recruitment of inflammatory cells into lung parenchyma and alveoli was dependent on CD4 ϩ T cells, underlining the importance of antigen-driven responses in amplifying the inflammatory response (42).…”
Section: Discussionmentioning
confidence: 99%
“…The in situ proliferation of lung macrophages after damage induced by bleomycin and hyperoxia in hamsters (39) as well as an increase in the proportion of proliferating macrophages in chronic lung inflammation in humans (40) have been demonstrated. Conversely, the migration of inflammatory cells through the vasculature into the lung induced proliferation of type II cells in the absence of morphological injury to the lung (41). Studies of the response to intratracheal antigen challenge in mice demonstrated that the recruitment of inflammatory cells into lung parenchyma and alveoli was dependent on CD4 ϩ T cells, underlining the importance of antigen-driven responses in amplifying the inflammatory response (42).…”
Section: Discussionmentioning
confidence: 99%
“…1977) and bleomycin (Adamson & Bowden 1974b, 1979) or as a consequence of inflammatory infiltration, e.g. following particle inhalation (Shami et al . 1986).…”
Section: Stem Cell Nichesmentioning
confidence: 99%
“…In subsequent experiments it was shown that, indeed, migration of inflammatory cells across the blood-air barrier was sufficient to trigger a proliferative response in the alveolar epithelium (19). Mice were made leukopenic by internal radiation with 89Sr and challenged with an intratracheal instillation of biologically inert carbon particles.…”
Section: Introductionmentioning
confidence: 99%