Type II cell proliferation related to migration of inflammatory cells into the lung

Shami, Susan G.; Evans, Michael J.; Martinez, Larry A

doi:10.1016/0014-4800(86)90048-1

Cited by 30 publications

(9 citation statements)

References 11 publications

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“…The in situ proliferation of lung macrophages after damage induced by bleomycin and hyperoxia in hamsters (39) as well as an increase in the proportion of proliferating macrophages in chronic lung inflammation in humans (40) have been demonstrated. Conversely, the migration of inflammatory cells through the vasculature into the lung induced proliferation of type II cells in the absence of morphological injury to the lung (41). Studies of the response to intratracheal antigen challenge in mice demonstrated that the recruitment of inflammatory cells into lung parenchyma and alveoli was dependent on CD4 ϩ T cells, underlining the importance of antigen-driven responses in amplifying the inflammatory response (42).…”

Section: Discussionmentioning

confidence: 99%

The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide.

Panoskaltsis‐Mortari¹,

Taylor²,

Yaeger³

et al. 1997

J. Clin. Invest.

117

119

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We have hypothesized that lung damage occurring in the peri-bone marrow transplant (BMT) period is critical for the subsequent generation of idiopathic pneumonia syndrome (IPS), a major complication following human BMT. The proinflammatory events induced by a common pre-BMT conditioning regimen, cyclophosphamide (Cytoxan ® ) (Cy) and total body irradiation, were analyzed in a murine BMT model. Electron microscopy indicated that Cy exacerbated irradiation-induced epithelial cell injury as early as day 3 after BMT. Allogenicity was an important contributing factor to lung injury as measured by lung wet and dry weights and decreased specific lung compliance. The most significant pulmonary dysfunction was seen in mice receiving both allogeneic T cells and Cy conditioning. IPS was associated with an influx of T cells, macrophages, and neutrophils early post-BMT. Hydroxyproline levels were not increased, indicating that the injury was not fibrotic early post-BMT. As early as 2 h after chemoradiation, host macrophages increased in number in the lung parenchyma.

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Section: Discussionmentioning

confidence: 99%

The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide.

Panoskaltsis‐Mortari¹,

Taylor²,

Yaeger³

et al. 1997

J. Clin. Invest.

117

119

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“…1977) and bleomycin (Adamson & Bowden 1974b, 1979) or as a consequence of inflammatory infiltration, e.g. following particle inhalation (Shami et al . 1986).…”

Section: Stem Cell Nichesmentioning

confidence: 99%

Pulmonary epithelial stem cells

Bishop

2004

Cell Proliferation

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Classically, the stem/progenitor cells of the pulmonary epithelium are considered to be the basal and mucous cells of the proximal airways, Clara cells in the bronchioles and type II pneumocytes in the alveoli. Recent data suggest that there is a variant of Clara cells, lying in pulmonary neuroendocrine bodies, that meets several stem cell criteria and that type II pneumocytes exist in at least two populations, one of which is more resistant to injury. However, a complete revision of our understanding of pulmonary stem cell biology is underway as a result of the discovery of pulmonary epithelium derived from blood-borne cells. In addition, the existence in the lung of a 'universal' pluripotent cell has long been speculated upon and now some initial evidence has emerged with the identification of a spore-like cell that can differentiate in vitro to bronchiolar tissue.

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“…In subsequent experiments it was shown that, indeed, migration of inflammatory cells across the blood-air barrier was sufficient to trigger a proliferative response in the alveolar epithelium (19). Mice were made leukopenic by internal radiation with 89Sr and challenged with an intratracheal instillation of biologically inert carbon particles.…”

Section: Introductionmentioning

confidence: 99%