Type I photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy

Pan, Chao; Zhao, Weijun; Zhao, Xiaolei; Liu, Zhengxin; Li, Xiangyu; Lv, Yanting; Wu, Xupeng; Zhu, Zhirong; Zhu, Weihong; Wang, Qi

doi:10.1016/j.gce.2022.07.004

Cited by 6 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As one of the most advanced PSs, aggregation-induced emission photosensitizers (AIE PSs) have received great attention due to their inherent advantages of high efficiency, good photostability, and excellent biocompatibility [28][29][30][31][32]. Precise molecular design by tuning the π-conjugation and electron donor-acceptor (D-A) moiety allowed AIE luminogens (AIEgens) to possess both Type I and Type II ROS generation abilities [33][34][35]. And the aggregation-induced intersystem crossing (AI-ISC) mechanism [36,37] has made AIE PSs more efficient in ROS generation in their aggregate state, which is pivotal for photodynamic-based masks.…”

Section: Introductionmentioning

confidence: 99%

Self-cleaning wearable masks for respiratory infectious pathogen inactivation by type I and type II AIE photosensitizer

Sun¹,

Bai²,

Yu³

et al. 2022

Biomaterials

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Self-cleaning wearable masks for respiratory infectious pathogen inactivation by type I and type II AIE photosensitizer

Sun¹,

Bai²,

Yu³

et al. 2022

Biomaterials

View full text Add to dashboard Cite

Dual‐Responsive and Aggregation‐Induced‐Emission Probe for Selective Imaging of Infectious Urolithiasis

Li,

Wang,

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Identifying infected stones is crucial due to their rapid growth and high recurrence rate. Our study presents the calcium‐magnesium dual‐responsive aggregation‐induced emission (AIE)‐active probe TCM‐5COOH, distinctively engineered to distinguish high‐threat infection calculi from metabolic stones. Upon incorporation of flexible alkyl carboxyl group, TCM‐5COOH featuring five carboxyl moieties demonstrates excellent water solubility and enhanced penetration into porous infectious stones. The robust chelation of TCM‐5COOH with stone surface‐abundant Ca2+ and Mg2+inhibits vibrational relaxation, thus triggering intense AIE signals. Remarkably, the resulting complex exhibits high insolubility, effectively anchoring within the porous structure of the infection calculi and offering prolonged illumination. Jobs’ plot method revealed similar responses characteristics for Ca2+ and Mg2+, with a 1:2 coordination number for both ions. Isothermal titration calorimetry (ITC) results demonstrated higher enthalpy change (ΔH) and lower entropy change (ΔS) for the reaction, indicating enhanced selectivity compared to TCM‐4COOH lacking the alkyl carboxyl group. Synchrotron X‐ray absorption fine spectroscopy (XAFS) validated TCM‐5COOH's interaction with Ca2+ and Mg2+ at the micro level. This dual‐responsive probe excels in identifying infectious and metabolic calculi, compatible with endoscopic modalities and laser excitation, thereby prompting clinical visualization and diagnostic assessment.This article is protected by copyright. All rights reserved

show abstract

Microalbuminuria sensitive near‐infrared AIE probe for point‐of‐care evaluating kidney diseases

Zhu,

Chen,

Liao

et al. 2024

Aggregate

Self Cite

View full text Add to dashboard Cite

Urinary microalbumin (mALB) serves as an exceptionally sensitive indicator for the early detection of kidney damage, playing a pivotal role in identifying chronic renal failure and kidney lesions in individuals. Nevertheless, the current fluorescent methodologies for point‐of‐care (POC) diagnosis of mALB in real urine still exhibit suboptimal performance. Herein, the development and synthesis of QM‐N2, an albumin‐activated near‐infrared (NIR) aggregation‐induced emission (AIE) fluorescent probe, are presented. The strategic incorporation and positioning of quaternary ammonium salts within the quinoline‐malononitrile (QM) scaffold significantly influence solubility and luminescence characteristics. Specifically, the quaternary ammonium salt‐free variant, QM‐OH, and the quaternary ammonium salt integrated at the donor function group (DFG) site, QM‐N1, display limited solubility in aqueous solutions while demonstrating a distinct fluorescence signal. Conversely, the incorporation of quaternary ammonium salt at the conformational functional group (CFG) site in QM‐N2 imparts superior dispersibility in water and reduces the initial fluorescence. Furthermore, the integration of a well‐defined D‐π‐A structure within QM‐N2 enables itself with near‐infrared emission, which is crucial for mitigating interference from autofluorescence present in urine samples. Upon interaction with albumin, QM‐N2 forms a tight bond with the IIA site of the subdomain of human serum albumin (HSA), inducing alterations in protein configuration and constraining the intrinsic motion of fluorescent molecules. This interaction induces fluorescence, facilitating the sensitive detection of trace albumin. Ultimately, QM‐N2 is applied for POC testing of mALB using portable equipment, particularly in the diagnosis of mALB‐related diseases, notably chronic renal failure. This positioning underscores its potential as an ideal candidate for self‐health measurement at home or in community hospitals.

show abstract

Type I photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy

Cited by 6 publications

References 54 publications

Self-cleaning wearable masks for respiratory infectious pathogen inactivation by type I and type II AIE photosensitizer

Self-cleaning wearable masks for respiratory infectious pathogen inactivation by type I and type II AIE photosensitizer

Dual‐Responsive and Aggregation‐Induced‐Emission Probe for Selective Imaging of Infectious Urolithiasis

Microalbuminuria sensitive near‐infrared AIE probe for point‐of‐care evaluating kidney diseases

Contact Info

Product

Resources

About