Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

Kodama, Tatsuhiko; Freeman, Mason W.; Rohrer, Lucia; Zabrecky, James R.; Matsudaira, Paul; Krieger, Monty

doi:10.1038/343531a0

Cited by 989 publications

(531 citation statements)

References 40 publications

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“…7b). These results suggest Endocytic uptake of GA-BSA by mesangial cells from SR-A knock-out mice Among the scavenger receptors, SR-A [17], CD36 [18], SR-BI [19], and LOX-1 [20] have been identified as the AGE receptors. In this study we determined the extent of contribution of SR-A to the endocytic degradation of GA-BSA by mesangial cells.…”

Section: Resultsmentioning

confidence: 77%

“…These cellular responses to AGE proteins are believed to be mediated by AGE receptors which include the receptor for AGE (RAGE) [15], oligosaccharyltransferase-48 (OST-48), 80K-H, galectin-3 complex [16], and scavenger receptors such as the class A scavenger receptor (SR-A) [17], CD36 [18], SR-BI [19], and LOX-1 [20]. Several AGE receptor(s) in mesangial cells were characterised from the potential link to diabetic nephropathy [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

et al. 2005

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Aims/hypothesis: Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. Methods: Glycolaldehyde-modified BSA (GA-BSA) and methylglyoxalmodified BSA (MG-BSA) were prepared as model AGE proteins, and their in vivo plasma clearance was examined in mice, and renal uptake by in vitro studies with isolated renal mesangial cells. Results: Both 111 In-GA-BSA and 111

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Section: Resultsmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

et al. 2005

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“…A detailed developmental analysis of the gonadal expression pattern of Tesr was undertaken to help understand its potential role in testis development. Kangas et al, 1999Elomaa et al, 1995Kodama et al, 1990 Human MARCO NP_006761 46% / 65% …”

Section: Resultsmentioning

confidence: 99%

Novel scavenger receptor gene is differentially expressed in the embryonic and adult mouse testis

Sarraj

McClive

Wilmore

et al. 2005

Developmental Dynamics

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In an effort to understand the mechanisms that underpin gonadal differentiation at the time of sex determination, we identified a cDNA encoding a putative novel testis expressed scavenger receptor, Tesr. Based on its domain structure, we hypothesize that the function of Tesr is similar to that of other scavenger receptors that play roles in phagocytosis of apoptotic cells, cell-cell adhesion, and defense. Tesr mRNA was detected in fetal mouse gonads of both sexes at 11.5 days post coitum (dpc). From 12.0 dpc, Tesr expression rapidly decreased in the female and was maintained in the male. Expression was seen in embryonic mouse sites other than the testis, such as in brain, eye, head, heart, neural arch, and cartilage primordium. Tesr expression in the newborn testis was faint to undetectable, but it increased from 2 days postpartum (dpp) until 15 dpp and was found in a subset of interstitial cells and in germ and Sertoli cells. Tesr mRNA in the adult mouse testis was observed in Sertoli cells, spermatogonia, spermatocytes, round spermatids, and in a subset of interstitial cells. We conclude that Tesr is differentially expressed in the male vs. female embryonic gonad and is expressed in both the ovary and the testes postnatally after 2 dpp. Developmental Dynamics 234:1026 -1033, 2005.

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“…Its primary sequence was already determined in 1990 [1]. But the role of SRA1 in foam cell formation is still not well understood.…”

Section: Introductionmentioning

confidence: 99%

Mimicking phosphorylation at Ser‐48 strongly reduces surface expression of human macrophage scavenger receptor class A: implications on cell motility

Heider

Wintergerst

2001

FEBS Letters

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The role of human macrophage scavenger receptor A1 (SRA1) in the development of atherosclerotic lesions is still scarcely defined. Substituting serine 48 in human SRA1 by an aspartate demonstrated that (1) surface expression of the mutated receptor was 13-fold decreased; (2) the amount of cell-associated Texas red-labeled acetylated low density lipoprotein (LDL) in mutant receptor-expressing cells was almost threefold reduced; (3) the migration of mutant receptor-transfected cells towards surfaces coated with oxidized LDL decreased by almost 60% compared to cells that were transfected with the wild type receptor. Phosphorylation of the cytoplasmic part of SRA1 may help to modulate the residence time of macrophages in atherosclerotic lesions. ß

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Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

Cited by 989 publications

References 40 publications

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

Novel scavenger receptor gene is differentially expressed in the embryonic and adult mouse testis

Mimicking phosphorylation at Ser‐48 strongly reduces surface expression of human macrophage scavenger receptor class A: implications on cell motility

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