Type I interferons provide additive signals for murine regulatory B cell induction by <i>Schistosoma mansoni</i> eggs

Obieglo, Katja; Costain, Alice; Webb, Lauren M.; Ozir‐Fazalalikhan, Arifa; Brown, None Shelia L.; MacDonald, Andrew S.; Smits, Hermelijn H.

doi:10.1002/eji.201847858

Cited by 16 publications

(13 citation statements)

References 48 publications

(88 reference statements)

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“…Alternatively, the type I IFN response could induce regulatory B cells that protect against immunopathology. 43 Thus, through diverse potential mechanisms, enteric helminths can confer host resistance against respiratory viral infections and disease pathogenesis ( Table 1 ).…”

Section: Beneficial Outcomesmentioning

confidence: 99%

Helminth–virus interactions: determinants of coinfection outcomes

2021

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Viral infections are often studied in model mammalian organisms under specific pathogen-free conditions. However, in nature, coinfections are common, and infection with one organism can alter host susceptibility to infection with another. Helminth parasites share a long coevolutionary history with mammalian hosts and have shaped host physiology, metabolism, immunity, and the composition of the microbiome. Published studies suggest that helminth infection can either be beneficial or detrimental during viral infection. Here, we discuss coinfection studies in mouse models and use them to define key determinants that impact outcomes, including the type of antiviral immunity, the tissue tropism of both the helminth and the virus, and the timing of viral infection in relation to the helminth lifecycle. We also explore the current mechanistic understanding of how helminth-virus coinfection impacts host immunity and viral pathogenesis. While much attention has been placed on the impact of the gut bacterial microbiome on immunity to infection, we suggest that enteric helminths, as a part of the eukaryotic macrobiome, also represent an important modulator of disease pathogenesis and severity following virus infection.

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Section: Beneficial Outcomesmentioning

confidence: 99%

Helminth–virus interactions: determinants of coinfection outcomes

2021

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“…A proposed mechanism for this IL‐10 induction involves type 1 interferons that helminths can induce. Type 1 interferons are able to serve as an additive signal to induce IL‐10 production in Bregs cells but are unlikely to participate in the development of Bregs in response to S mansoni eggs, since this signal is dispensable for activation 104 . Surprisingly, despite the strong Th2 responses to these helminths, S mansoni eggs can protect against the development of allergic airway inflammation by reducing lung eosinophilia and allergen‐specific IgG1 and IgE antibodies 105 …”

Section: How To Induce Breg Cellsmentioning

confidence: 99%

B regulatory cells in allergy

Satitsuksanoa

Jansen

et al. 2020

Immunological Reviews

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B cells have classically been recognized for their unique and indispensable role in the production of antibodies. Their potential as immunoregulatory cells with anti‐inflammatory functions has received increasing attention during the last two decades. Herein, we highlight pioneering studies in the field of regulatory B cell (Breg) research. We will review the literature on Bregs with a particular focus on their role in the regulation of allergic inflammation.

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“…It would be interesting to know if IFNs are generally more important in single-cellular parasitic infections. That said, the multicellular helminth Schistosoma mansoni can induce a systemic type I IFN signature in mice and activate TLR3 in DCs in vitro , suggesting that a role for type I IFNs in parasitic worm infections is certainly possible ( 220 , 221 ). Continued work to delineate the cellular sources and functions of type I IFNs in malaria and other parasitic diseases may reveal novel opportunities for therapeutic intervention and help uncover novel functions of type I IFNs.…”

Section: Infectious Diseasesmentioning

confidence: 99%

Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease

Fox

Locke

Lenschow³

2020

Front. Immunol.

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Type I interferons (IFNs) are critical effector cytokines of the immune system and were originally known for their important role in protecting against viral infections; however, they have more recently been shown to play protective or detrimental roles in many disease states. Type I IFNs consist of IFNα, IFNβ, IFNϵ, IFNκ, IFNω, and a few others, and they all signal through a shared receptor to exert a wide range of biological activities, including antiviral, antiproliferative, proapoptotic, and immunomodulatory effects. Though the individual type I IFN subtypes possess overlapping functions, there is growing appreciation that they also have unique properties. In this review, we summarize some of the mechanisms underlying differential expression of and signaling by type I IFNs, and we discuss examples of differential functions of IFNα and IFNβ in models of infectious disease, cancer, and autoimmunity.

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Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs

Cited by 16 publications

References 48 publications

Helminth–virus interactions: determinants of coinfection outcomes

Helminth–virus interactions: determinants of coinfection outcomes

B regulatory cells in allergy

Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease

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