Type I interferon induces TCR-dependent and -independent antimicrobial responses in γδ intraepithelial lymphocytes
Matthew A. Fischer,
Luo Jia,
Karen L. Edelblum
Abstract:Intraepithelial lymphocytes (IEL) expressing the γδ T cell receptor (TCR) survey the intestinal epithelium to limit the invasion of microbial pathogens. The production of type I interferon (IFN) is a central component of an antiviral immune response, yet how these pro-inflammatory cytokines contribute to γδ IEL effector function remains unclear. Based on the unique activation status of IELs, and their ability to bridge innate and adaptive immunity, we investigated the extent to which type I IFN signaling modul… Show more
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