Abstract:Upon viral infection, the release of type I interferons (IFNs) plays a crucial role in limiting viral replication, reducing tissue damage, and boosting both innate and adaptive immune responses. A plasmacytoid dendritic cell (pDC) is a professional type I IFN-producing cell with the ability to produce large amounts of type I IFN quickly. However, when pDCs experience dysfunction or impairment in their ability to produce type I IFNs, the susceptibility to severe viral infections increases. Patients with severe … Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.