volume 191, issue 5, P2771-2779 2013
DOI: 10.4049/jimmunol.1301093
View full text
Abhisake Kole, JianPing He, Aymeric Rivollier, Danielle D. Silveira, Kazuya Kitamura, Kevin J. Maloy, Brian L. Kelsall

Abstract: We explored the function of endogenous type I interferons (IFN-1) in the colon using the T cell adoptive transfer model of colitis. Colon mononuclear phagocytes (MP) constitutively produced IFN-1 in a TRIF-dependent manner. Transfer of CD4+CD45RBhi T cells from wild type (WT) or interferon α/β receptor subunit 1 knockout (IFNAR1−/−) mice into RAG−/− hosts resulted in similar onset and severity of colitis. In contrast, RAG−/− x IFNAR1−/− double knockout (DKO) mice developed accelerated severe colitis compared …

expand abstract