Type I hypersensitivity reactions in intestinal mucosae from rats infected with Fasciola hepatica

O'Malley, Kate; Sloan, T. B. M.; Joyce, Patrick; Baird, Alan W.

doi:10.1111/j.1365-3024.1993.tb00630.x

Cited by 19 publications

(6 citation statements)

References 18 publications

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“…This might be due to the fact that mast cells in the intestine are continuously activated as flukes present in the liver shed antigen. This finding contradicts the findings of Doy et al (1981) andO'Malley et al (1993), who reported an anaphylactic response in the gut after challenge with the parasite itself or with F. hepatica antigen.…”

Section: Figurecontrasting

confidence: 99%

Protection against Fasciola hepatica in the intestine is highly correlated with eosinophil and immunoglobulin G1 responses against newly excysted juveniles

Milligen¹,

Cornelissen²,

Bokhout³

1999

Parasite Immunology

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Rats were infected with Fasciola hepatica and challenged at regular intervals up to 38 weeks using an ex vivo gut loop, a technique developed in our laboratory. The kinetics of the observed immune responses against F. hepatica in gut tissue and serum were investigated and correlated to protection. Immunohistochemical methods were used to measure the frequency of eosinophils, immunoglobulin (Ig)E-positive cells, and mucosal mast cells in the gut loop, and to determine whether the newly excysted juveniles were coated with IgG antibodies or surrounded by eosinophils, or both. Enzyme-linked immunosorbent assays and a radioimmuno assay were used to measure serum antibody reactive with newly excysted juveniles. Results showed that protection was highly correlated with the frequency of eosinophils and IgE-positive cells in the gut, but was only moderately correlated with the frequency of mucosal mast cells. Newly excysted juveniles taken from rats exhibiting high levels of protection were always coated with IgG antibodies and surrounded by eosinophils. Protection was highly correlated with titers of serum IgG1 antibodies directed against newly excysted juveniles, but was only weakly correlated with titers of serum IgA and IgE antibodies. Because protection was highly correlated with IgG1 in gut tissue and serum, and with eosinophils in gut tissue, we suggest that IgG1 and eosinophils are important in protecting rats against F. hepatica.

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Section: Figurecontrasting

confidence: 99%

Protection against Fasciola hepatica in the intestine is highly correlated with eosinophil and immunoglobulin G1 responses against newly excysted juveniles

Milligen¹,

Cornelissen²,

Bokhout³

1999

Parasite Immunology

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“…Functionally, mast cell and eosinophil activation caused by an antigenic trigger, affects both the secretory and motor functions of the intestines [15]. These defensive reactions can be modulated by the enteric nervous system [16]. It has been recently recognised that not just regular mucosa without PPs and ILFs, but also the area of PPs are richly innervated [17].…”

Section: The Organization Of the Mucosa-associated Lymphoid Tissuementioning

confidence: 99%

The Possible Role of Isolated Lymphoid Follicles in Colonic Mucosal Repair

Sípos

Műzes

Galamb

et al. 2009

Pathol. Oncol. Res.

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The continuous reformation and rapid repair of the colonic mucosa is essential for avoiding the aggregation of pernicious mutations induced by bacterial, toxic, or mitogenic factors. Gut-associated lymphoid tissue is supposed to play a central role in the organization of the repair mechanisms. In inflammatory conditions, the number, the diameter and the density of isolated lymphoid follicles (ILFs) are increasing. They are involved not just in immune surveillance, but their presence is also indispensable in normal mucosal regeneration of the colon. The relation of ILFs to the components of mucosal renewal such as bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts or crypt formation has not been directly studied, and data about their putative organizer role are scattered in scientific literature. Whether they act as a regenerative pool containing stem cells in case of mucosal damage, or they are responsible only for the optimal cytokine milieu for the differentiation of immigrating stem cells is a question under debate. Our aim is to review the relation of ILFs to the different elements of colonic mucosal repair.

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“…Researchers have reported the effect of other intestinal parasites on ion transport in the gastrointestinal tract, including the effect of T. spiralis infections on intestinal ion transport in the colon in the domestic guinea pig Cavia porcellus , and the effect of F. hepatica infection on ion transport in the rat intestine [76,77,78]. Research by Kosik-Bogacka et al (2010, 2011) [70,71] showed that infection with H. diminuta causes changes in the transport of ions in the host’s small and large intestines.…”

Section: Rat Tapeworm Hymenolepis Diminuta Rudolphi 1819mentioning

confidence: 99%

Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepis diminuta–Rattus norvegicus

Kapczuk

Kosik-Bogacka

Łanocha-Arendarczyk

et al. 2018

IJMS

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The rat tapeworm Hymenolepis diminuta is a parasite of the small intestine of rodents (mainly mice and rats), and accidentally humans. It is classified as a non-invasive tapeworm due to the lack of hooks on the tapeworm’s scolex, which could cause mechanical damage to host tissues. However, many studies have shown that metabolites secreted by H. diminuta interfere with the functioning of the host’s gastrointestinal tract, causing an increase in salivary secretion, suppression of gastric acid secretion, and an increase in the trypsin activity in the duodenum chyme. Our work presents the biochemical and molecular mechanisms of a parasite-host interaction, including the influence on ion transport and host intestinal microflora, morphology and biochemical parameters of blood, secretion of antioxidant enzymes, expression of Toll-like receptors, mechanisms of immune response, as well as the expression and activity of cyclooxygenases. We emphasize the interrelations between the parasite and the host at the cellular level resulting from the direct impact of the parasite as well as host defense reactions that lead to changes in the host’s tissues and organs.

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Type I hypersensitivity reactions in intestinal mucosae from rats infected with Fasciola hepatica

Cited by 19 publications

References 18 publications

Protection against Fasciola hepatica in the intestine is highly correlated with eosinophil and immunoglobulin G1 responses against newly excysted juveniles

Protection against Fasciola hepatica in the intestine is highly correlated with eosinophil and immunoglobulin G1 responses against newly excysted juveniles

The Possible Role of Isolated Lymphoid Follicles in Colonic Mucosal Repair

Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepis diminuta–Rattus norvegicus

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