Type I hair cell degeneration in the utricular macula of the waltzing guinea pig

Severinsen, Stig Åvall; Raarup, Merete K.; Ulfendahl, Mats; Wogensen, Lise; Nyengaard, Jens Randel; Kirkegaard, Mette

doi:10.1016/j.heares.2007.11.009

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Similar declines have been observed in mouse and guinea pig [85, 86]. In several of the aforementioned studies, aged maculae showed less hair cell loss than the cristae, suggesting the utricle and saccule might be less susceptible.…”

Section: Vestibular Cell Types and Subtypes Might Exhibit Differensupporting

confidence: 73%

Development and regeneration of vestibular hair cells in mammals

Burns

Stone

2017

Seminars in Cell & Developmental Biology

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Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity. The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small organs in the inner ear. Damage to hair cells and their innervating neurons can cause crippling symptoms such as vertigo, visual field oscillation, and imbalance. In adult rodents, some Type II hair cells are regenerated and become re-innervated after damage, presenting opportunities for restoring vestibular function after hair cell damage. This article reviews features of vestibular sensory cells in mammals, including their basic properties, how they develop, and how they are replaced after damage. We discuss molecules that control vestibular hair cell regeneration and highlight areas in which our understanding of development and regeneration needs to be deepened.

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Section: Vestibular Cell Types and Subtypes Might Exhibit Differensupporting

confidence: 73%

Development and regeneration of vestibular hair cells in mammals

Burns

Stone

2017

Seminars in Cell & Developmental Biology

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“…Kirkegaard et al used a stereo optical method, i.e. a dissector technique, and they followed the cells through the depth of 30 mm sections (Gundersen et al, 1999;Severinsen et al, 2008). In the work of Kirkegaard et al every eighth section in each macula of the thickness described above was analyzed.…”

Section: Discussionmentioning

confidence: 99%

Morphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants

et al. 2012

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“…Thus, vestibular deprivation before or during this period delays and alters motor development 2 . Several strains of mutant rats 3,4 and guinea pigs 5 with genetic alterations of inner‐ear development present abnormal motor behavior. A much larger number of such strains exists among mutant mice 6–12 .…”

Section: Introductionmentioning

confidence: 99%

Vestibular Critical Period, Maturation of Central Vestibular Neurons, and Locomotor Control

Eugène

Deforges

Vibert

et al. 2009

Annals of the New York Academy of Sciences

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Mutant mice are a good model to study to what extent the postnatal activity of sensory afferents is necessary for the maturation of central neurons. In particular, the question arises whether the signals carried by the first-order vestibular neurons, which encode information on the head movement of pups, are necessary for the maturation of second-order vestibular neurons. To address that question, juvenile and adult transgenic, vestibular-deficient mutants where a null mutation of the KCNE1 potassium-channel gene leads to degeneration of all hair cells of the inner ear just after birth were studied. These KCNE1(-/-) mutants are deaf and show quasi-constant head bobbing and a permanent shaker/waltzer phenotype. This behavior is not due to persistent abnormalities of the membrane properties of central vestibular neurons, because their maturation is delayed but not impaired by the absence of sensory vestibular information. On the other hand, the data shed light on how the membrane properties of vestibular neurons might be modified according to functional requirements or following lesions. The expression levels of the protein calretinin that regulates the intracellular free-calcium concentration in central vestibular neurons could play a major role both in intact animals and following labyrinthectomy. By comparing the KCNE1(-/-) mutant mice to other vestibular-deficient animals, it was concluded that the suppression of vestibular inputs during a "critical period" of postnatal development can induce a permanent circling behavior, but that this phenotype is not always due to congenital vestibular deficiency.

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Type I hair cell degeneration in the utricular macula of the waltzing guinea pig

Cited by 3 publications

References 34 publications

Development and regeneration of vestibular hair cells in mammals

Development and regeneration of vestibular hair cells in mammals

Morphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants

Vestibular Critical Period, Maturation of Central Vestibular Neurons, and Locomotor Control

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