Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans

Langberg, Henning; Skovgaard, Dorthe; Petersen, Lone; Bülow, Jens; Kjær, Michael

doi:10.1111/j.1469-7793.1999.00299.x

Cited by 291 publications

(309 citation statements)

References 47 publications

(88 reference statements)

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“…Collagen synthesis in the patellar tendon Pretest microdialysis was performed, with no exercise or testing done during the preceding two days (Langberg et al 1999). The post sampling was executed the day after the last training session (16-28 hours after exercise).…”

Section: Methodsmentioning

confidence: 99%

“…The catheters were perfused (CMA 100) at a rate of 2 µl/min. After the microdialysis catheters had been positioned the subjects rested for at least 90 min before starting the sampling (4 hours), to ensure that the insertion trauma was minimised (Langberg et al 1999). The samples were immediately frozen at −80° C until analyses were done.…”

Section: Methodsmentioning

confidence: 99%

“…Exercise has been shown to increase the turnover of tissue within tendons both acutely and as a result of a prolonged training intervention (Langberg et al 1999;Langberg et al 2000;Miller et al 2005;Kongsgaard et al 2007;Langberg et al 2007). Animal studies show that exercise improves the physical properties of tendons, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Effect of range of motion in heavy load squatting on muscle and tendon adaptations

et al. 2013

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This file was dowloaded from the institutional repository Brage NIH -brage.bibsys.no/nih Bloomquist, K. L., Langberg, H. C., Karlsen, S., Madsgaard, S., Boesen, M., Raastad, T. (2013 AbstractPurpose Manipulating joint range of motion during squat training may have differential effects on adaptations to strength training with implications for sports and rehabilitation. Consequently, the purpose of this study was to compare the effects of squat training with a short vs. a long range of motion.Methods Male students (n=17) were randomly assigned to 12 weeks of progressive squat training (repetition matched, repetition maximum sets) performed as either a) deep squat (0-120˚ of knee flexion); n=8 (DS) or (b) shallow squat (0-60˚ of knee flexion); n=9 (SS). Strength (1 RM and isometric strength), jump performance, muscle architecture and cross-sectional area (CSA) of the thigh muscles, as well as CSA and collagen synthesis in the patellar tendon, were assessed before and after the intervention. ResultsThe DS group increased 1RM in both the SS and DS with ~20±3%, while the SS group achieved a 36±4% increase in the SS, and 9±2% in the DS (P<0.05). However, the main finding was that DS training resulted in superior increases in front thigh muscle CSA (4-7%) compared to SS training, whereas no differences were observed in patellar tendon CSA. In parallel with the larger increase in front thigh muscle CSA, a superior increase in isometric knee extension strength at 75˚(6±2%) and 105˚(8±1%) knee flexion, and squat-jump performance (15±3%), were observed in the DS group compared to the SS group. ConclusionTraining deep squats elicited favourable adaptations on knee extensor muscle size and function compared to training shallow squats.Running title: Squat range of motion and musculotendinous adaptations 3

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effect of range of motion in heavy load squatting on muscle and tendon adaptations

et al. 2013

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“…For example, procollagen type I C-terminal peptide (PICP), a marker for type I collagen synthesis, rose 3-to 7-fold from basal level 72 h after acute exercise in human peritendinous tissue (Langberg et al, 1999(Langberg et al, , 2001Kjaer et al, 2000). Also, the role of TGF-β1 in relation to exerciseinduced type I collagen synthesis in human tendons has been reported.…”

Section: Regulation Of Gene Expression In Fibroblasts By Mechanical Lmentioning

confidence: 96%

Mechanoregulation of gene expression in fibroblasts

Wang

Thampatty

Lin

et al. 2007

Gene

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Mechanical loads placed on connective tissues alter gene expression in fibroblasts through mechanotransduction mechanisms by which cells convert mechanical signals into cellular biological events, such as gene expression of extracellular matrix components (e.g., collagen). This mechanical regulation of ECM gene expression affords maintenance of connective tissue homeostasis. However, mechanical loads can also interfere with homeostatic cellular gene expression and consequently cause the pathogenesis of connective tissue diseases such as tendinopathy and osteoarthritis. Therefore, the regulation of gene expression by mechanical loads is closely related to connective tissue physiology and pathology. This article reviews the effects of various mechanical loading conditions on gene regulation in fibroblasts and discusses several mechanotransduction mechanisms. Future research directions in mechanoregulation of gene expression are also suggested.

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“…A study of collagen turnover, measured using microdialysis in the peritendinous regions of the Achilles tendon, showed that an acute bout of exercise increased the collagen synthesis of type I collagen 72 hours after exercise (Langberg et al, 1999b). Further studies by the same researchers of the synthesis and degradation of collagen after a marathon run show that the synthesis of collagen reaches a peak three days after the run and returns to normal levels again after five days .…”

Section: Effect Of Exercise On Tendonsmentioning

confidence: 99%

Iontophoresis with or without dexamethazone in the treatment of acute Achilles tendon pain

Neeter

Thomeé

Silbernagel

et al. 2003

Scandinavian Med Sci Sports

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The purpose of this double‐blind study was to evaluate the effects of iontophoresis with dexamethazone to iontophoresis with saline solution on patients who had acute (less than 3 months) pain from the Achilles tendon, in terms of range of motion, muscular endurance, pain and symptoms. Twenty‐five patients (15 men and 10 women), aged between 18 and 76 years (mean = 38), were evaluated before and after 2 weeks of treatment with iontophoresis, as well as after 6 weeks, 3 and 6 months and 1 year. Two groups were treated for 2 weeks with iontophoresis for each treatment. Three ml of dexamethazone were used for the experiment group (n = 14) and 3 ml of saline solution for the control group (n = 11). Both groups then followed the same rehabilitation programme for 10 weeks. Good reliability was found for the toe‐raise and range of motion tests. Poor reliability was, however, found for the pain on palpation test, which was therefore excluded. No difference was found between or within groups for the toe‐raise test. Several significant improvements were seen in the experiment group but not in the control group, in the range of motion test, pain during and after physical activity, pain during walking and walking up and down stairs, morning stiffness and tendon swelling. Even though the small sample size limits the possibilities to draw definite conclusions, we conclude from the present study, using a double‐blind, randomised approach and a 1‐year follow‐up period, that positive effects from using iontophoresis with dexamethazone were found in the treatment of patients with acute Achilles tendon pain.

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Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans

Cited by 291 publications

References 47 publications

Effect of range of motion in heavy load squatting on muscle and tendon adaptations

Effect of range of motion in heavy load squatting on muscle and tendon adaptations

Mechanoregulation of gene expression in fibroblasts

Iontophoresis with or without dexamethazone in the treatment of acute Achilles tendon pain

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