Type I collagen homotrimers: A potential cancer‐specific interventional target

Zhou, Ying; Zhang, Linzhu; Xie, Jiang; Han, Junhong

doi:10.1002/mog2.16

MedComm – Oncology

2022

DOI: 10.1002/mog2.16

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Type I collagen homotrimers: A potential cancer‐specific interventional target

Ying Zhou

Linzhu Zhang

Jiang Xie

et al.

Abstract: Pancreatic cancer cell‐derived homotrimer type 1 collagen plays an important role in the pathogenesis of pancreatic cancer. Homotrimer type 1 collagen produced by pancreatic cancer cells upregulated proliferation‐related pathways through the integrin α3β1 axis. Deletion of homotrimer type 1 collagen in genetically engineered mouse models altered the intratumoral microbiome, increased T‐cell infiltration, enhanced anti‐PD‐1 therapy, and ultimately inhibited tumor growth.

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Mechanisms by which the intestinal microbiota affects gastrointestinal tumours and therapeutic effects

He,

Li,

Jia

et al. 2023

Mol Biomed

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The intestinal microbiota is considered to be a forgotten organ in human health and disease. It maintains intestinal homeostasis through various complex mechanisms. A significant body of research has demonstrated notable differences in the gut microbiota of patients with gastrointestinal tumours compared to healthy individuals. Furthermore, the dysregulation of gut microbiota, metabolites produced by gut bacteria, and related signal pathways can partially explain the mechanisms underlying the occurrence and development of gastrointestinal tumours. Therefore, this article summarizes the latest research progress on the gut microbiota and gastrointestinal tumours. Firstly, we provide an overview of the composition and function of the intestinal microbiota and discuss the mechanisms by which the intestinal flora directly or indirectly affects the occurrence and development of gastrointestinal tumours by regulating the immune system, producing bacterial toxins, secreting metabolites. Secondly, we present a detailed analysis of the differences of intestinal microbiota and its pathogenic mechanisms in colorectal cancer, gastric cancer, hepatocellular carcinoma, etc. Lastly, in terms of treatment strategies, we discuss the effects of the intestinal microbiota on the efficacy and toxic side effects of chemotherapy and immunotherapy and address the role of probiotics, prebiotics, FMT and antibiotic in the treatment of gastrointestinal tumours. In summary, this article provides a comprehensive review of the pathogenic mechanisms of and treatment strategies pertaining to the intestinal microbiota in patients with gastrointestinal tumours. And provide a more comprehensive and precise scientific basis for the development of microbiota-based treatments for gastrointestinal tumours and the prevention of such tumours.

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Mechanisms by which the intestinal microbiota affects gastrointestinal tumours and therapeutic effects

He,

Li,

Jia

et al. 2023

Mol Biomed

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show abstract

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Type I collagen homotrimers: A potential cancer‐specific interventional target

Cited by 1 publication

References 6 publications

Mechanisms by which the intestinal microbiota affects gastrointestinal tumours and therapeutic effects

Mechanisms by which the intestinal microbiota affects gastrointestinal tumours and therapeutic effects

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