Type-dependent differential expression of neuropeptide Y in chicken hypothalamus (Gallus domesticus)

Chen, Guiqian; Hu, Xiufang; Sugahara, Kunio; Chen, Jishuang; Song, Xuemei; Zheng, Huichao; Jiang, Yongqing; Huang, Xin; Jiang, Jingwei; Zhou, Weidong

doi:10.1631/jzus.2007.b0839

Cited by 16 publications

(13 citation statements)

References 29 publications

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“…These results suggest that endogenous NPY in the brain may function as an orexigenic neuropeptide in chicks. Furthermore, the NPY content in the hypothalamus of embryos and the mRNA expression level of NPY in the hypothalamic nuclei in chickens are different between layers and broilers (Zhou et al, 2006; Chen et al, 2007). It is therefore possible that NPY contributes to the difference in food intake and growth rate in chickens.…”

Section: Orexigenic Neuropeptidesmentioning

confidence: 99%

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

Tachibana

Tsutsui

2016

Front. Neurosci.

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Feeding is an essential behavior for animals to sustain their lives. Over the past several decades, many neuropeptides that regulate feeding behavior have been identified in vertebrates. These neuropeptides are called “feeding regulatory neuropeptides.” There have been numerous studies on the role of feeding regulatory neuropeptides in vertebrates including birds. Some feeding regulatory neuropeptides show different effects on feeding behavior between birds and other vertebrates, particularly mammals. The difference is marked with orexigenic neuropeptides. For example, melanin-concentrating hormone, orexin, and motilin, which are regarded as orexigenic neuropeptides in mammals, have no effect on feeding behavior in birds. Furthermore, ghrelin and growth hormone-releasing hormone, which are also known as orexigenic neuropeptides in mammals, suppress feeding behavior in birds. Thus, it is likely that the feeding regulatory mechanism has changed during the evolution of vertebrates. This review summarizes the recent knowledge of peptidergic feeding regulatory factors in birds and discusses the difference in their action between birds and other vertebrates.

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Section: Orexigenic Neuropeptidesmentioning

confidence: 99%

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

Tachibana

Tsutsui

2016

Front. Neurosci.

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“…Besides the PVN and IN, the LHy is also thought to be involved in the regulation of food intake and body weight. 37 However, this study showed that a limited number of NPY-ir neurons were found within the IH-IN, and no NPY-ir neurons were observed in the LHy. Our results correspond with the findings that neither NPY-ir neurons nor NPY mRNA were found in the IN of quails, 26,28 pigeons, 30 and chickens.…”

Section: Discussionmentioning

confidence: 53%

“…27,35,36 Besides the PVN and IN, the lateral hypothalamus (LHy) is also involved in the regulation of food intake in birds. 1,37…”

Section: Introductionmentioning

confidence: 99%

“…38 To date, the possible role(s) of NPY in the regulation of body weight and feeding behavior during the reproductive cycle of the native Thai chicken has never been described and it has been suggested that NPY functions differently in the brain of broilers and layers. 37,39 Thus, the objective of the study is to elucidate whether changes in body weight correlate with the number of NPY-ir neurons across the reproductive stages in female native Thai chickens. The numbers of NPY-ir neurons in the hypothalamic areas and body weight were compared among four reproductive stages.…”

Section: Introductionmentioning

confidence: 99%

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Distribution and variation of neuropeptide Y in the brain of native Thai chicken

Sartsoongnoen

Kamkrathok

Songserm

et al. 2020

Avian Biology Research

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Neuropeptide Y (NPY) plays a pivotal role in food intake and body weight regulation in both birds and mammals. Unlike imported broilers and layers, native Thai chicken, a tropical non-seasonal breeding species, has lower body weight and exhibits strongly maternal behaviors which, in turn, affect feeding behavior during the reproductive cycle. The aim of this study was to investigate the role(s) of NPY that might be associated with the reproductive cycle of female native Thai chickens using immunohistochemistry technique. The distributions of NPY-immunoreactive (-ir) neurons and fibers in the brain of laying and fasted chickens was also elucidated. Changes in body weight and number of NPY-ir neurons in the nucleus paraventricularis magnocellularis (PVN) were compared across reproductive stages. The results revealed that NPY-ir neurons and fibers were distributed throughout the brain with the greatest density located in the PVN. Differences in the number of NPY-ir neurons in the PVN were found across reproductive stages. The numbers were lowest in non-egg laying and egg laying stages and significantly higher during egg-incubating and chick-rearing stages. Changes in body weight were inversely related to the number of NPY-ir neurons across reproductive stages. In addition, food restriction caused an increase in NPY immunoreactivity, confirming the role of NPY in response to food restriction. Taken together, the present findings suggest that the NPYergic system in the PVN plays an important role in the regulation of food intake during the reproductive cycle in this non-seasonal breeding tropical species.

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“…In a hungry or food-restricted state, the transcription of NPY was significantly enhanced in the hypothalamus of broilers, and the activity of neurons was also increased. Additionally, the ICV injection of NPY could significantly promote feeding behavior [ 53 ]. AgRP is a natural antagonist of melanocortin, which competes with α-MSH, an agonist of melanocortin, to bind to MC4R and inhibit its anorexic effects [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative transcriptome analysis of hypothalamus-regulated feed intake induced by exogenous visfatin in chicks

Zhang

Han

et al. 2018

BMC Genomics

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BackgroundThe intracerebroventricular injection of visfatin increases feed intake. However, little is known about the molecular mechanism in chicks. This study was conducted to assess the effect of visfatin on the feeding behavior of chicks and the associated molecular mechanism.ResultsIn response to the intraventricular injection of 40 ng and 400 ng visfatin, feed intake in chicks was significantly increased, and the concentrations of glucose, insulin, TG, HDL and LDL were significantly altered. Using RNA-seq, we identified DEGs in the chick hypothalamus at 60 min after injection with various doses of visfatin. In total, 325, 85 and 519 DEGs were identified in the treated chick hypothalamus in the LT vs C, HT vs C and LT vs HT comparisons, respectively. The changes in the expression profiles of DEGs, GO functional categories, KEGG pathways, and PPI networks by visfatin-mediated regulation of feed intake were analyzed. The DEGs were grouped into 8 clusters based on their expression patterns via K-mean clustering; there were 14 appetite-related DEGs enriched in the hormone activity GO term. The neuroactive ligand-receptor interaction pathway was the key pathway affected by visfatin. The PPI analysis of DEGs showed that POMC was a hub gene that interacted with the maximum number of nodes and ingestion-related pathways, including POMC, CRH, AgRP, NPY, TRH, VIP, NPYL, CGA and TSHB.ConclusionThese common DEGs were enriched in the hormone activity GO term and the neuroactive ligand-receptor interaction pathway. Therefore, visfatin causes hyperphagia via the POMC/CRH and NPY/AgRP signaling pathways. These results provide valuable information about the molecular mechanisms of the regulation of food intake by visfatin.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-4644-7) contains supplementary material, which is available to authorized users.

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Type-dependent differential expression of neuropeptide Y in chicken hypothalamus (Gallus domesticus)

Cited by 16 publications

References 29 publications

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

Distribution and variation of neuropeptide Y in the brain of native Thai chicken

Comparative transcriptome analysis of hypothalamus-regulated feed intake induced by exogenous visfatin in chicks

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