The greater reactivity in Type A subjects is a controversial issue. It is possible that anxiety, neuroticism and depression interact with Type A behaviour pattern, giving rise to different psychophysiological reactivity. To evaluate this hypothesis we studied 70 Italian healthy male volunteers. All were blue‐collar workers. Cardiac health was confirmed by a detailed family and medical history. Individual assessment included the Structured Interview, the Eysenck Personality Questionnaire (EPQ), the State‐Trait Anxiety Inventory (STAI) and the Depression Questionnaire (QD). To assess cardiac (rate‐pressure product) and electrodermic (skin conductance level) psychophysiological reactivity we used the following tasks: (1) Interactive Concentration Test (ICT); (2) Mental Arithmetic (MAT); (3) Workside Noises (WN). In Type A (A1 + A2) subjects a higher neuroticism score was associated with greater reactivity whereas in non A (X + B) subjects a lower neuroticism score was associated with greater reactivity. Subjects classified as Type A with lower depression scores had greater cardiovascular responses, whereas in non A subjects higher depression scores were associated with greater reactivity.