Type A Allatostatins from Drosophila melanogaster and Diplotera puncata Activate Two Drosophila Allatostatin Receptors, DAR-1 and DAR-2, Expressed in CHO Cells

Larsen, Martha J.; Burton, Katherine J.; Zantello, Marjorie R.; Smith, V. G.; Lowery, David E.; Kubiak, Teresa M.

doi:10.1006/bbrc.2001.5476

Cited by 76 publications

(37 citation statements)

References 23 publications

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“…The most plausible hypothesis is that the allatostatins A are released by the midgut endocrine cells and act on the allatostatin A receptors in these tissues. Allatostatins A activate receptors that couple to G i (Birgül et al 1999;Larsen et al 2001) and consistently inhibit physiological processes in insects, most notably juvenile hormone biosynthesis (Woodhead et al 1989), although not in flies, and hindgut contractions (Duve et al 1993). The expression of the allatostatin A receptor in the Malpighian tubules (Table 3) suggests that allatostatins A might function as anti-diuretic hormones directly acting on the Malpighian tubules.…”

Section: Functions Of Midgut Endocrine Cellsmentioning

confidence: 99%

Regulatory peptides in fruit fly midgut

2008

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Regulatory peptides were immunolocalized in the midgut of the fruit fly Drosophila melanogaster. Endocrine cells were found to produce six different peptides: allatostatins A, B and C, neuropeptide F, diuretic hormone 31, and the tachykinins. Small neuropeptide-F (sNPF) was found in neurons in the hypocerebral ganglion innervating the anterior midgut, whereas pigment-dispersing factor was found in nerves on the most posterior part of the posterior midgut. Neuropeptide-F (NPF)-producing endocrine cells were located in the anterior and middle midgut and in the very first part of the posterior midgut. All NPF endocrine cells also produced tachykinins. Endocrine cells containing diuretic hormone 31 were found in the caudal half of the posterior midgut; these cells also produced tachykinins. Other endocrine cells produced exclusively tachykinins in the anterior and posterior extemities of the midgut. Allatostatin-immunoreactive endocrine cells were present throughout the midgut. Those in the caudal half of the posterior midgut produced allatostatins A, whereas those in the anterior, middle, and first half of the posterior midgut produced allatostatin C. In the middle of the posterior midgut, some endocrine cells produced both allatostatins A and C. Allatostatin-C-immunoreactive endocrine cells were particularly prominent in the first half of the posterior midgut. Allatostatin B/MIP-immunoreactive cells were not consistently found and, when present, were only weakly immunoreactive, forming a subgroup of the allatostatin-C-immunoreactive cells in the posterior midgut. Previous work on Drosophila and other insect species suggested that (FM)RFamide-immunoreactive endocrine cells in the insect midgut could produce NPF, sNPF, myosuppressin, and/or sulfakinins. Using a combination of specific antisera to these peptides and transgenic fly models, we showed that the endocrine cells in the adult Drosophila midgut produced exclusively NPF. Although the Drosophila insulin gene Ilp3 was abundantly expressed in the midgut, Ilp3 was not expressed in endocrine cells, but in midgut muscle.

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Section: Functions Of Midgut Endocrine Cellsmentioning

confidence: 99%

Regulatory peptides in fruit fly midgut

2008

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“…However, many other functions of allatostatins were identi fi ed in later studies, including myoinhibitory and cardioinhibitory activities (Blackburn et al 2001 ;Price et al 2002 ) . Insect allatostatins can be divided into three different groups based on their distinct consensus amino acid sequences: allatostatin-A, allatostatin-B (or MIP, myoinhibitory peptides) and allatostatin-C. Several allatostatin receptors have been identi fi ed in D. melanogaster (Kreienkamp et al 2002 ;Johnson et al 2003a ;Larsen et al 2001 ;Lenz et al 2000aLenz et al , b, 2001Birgul et al 1999 ) .…”

Section: Neuropeptide Gpcrsmentioning

confidence: 99%

G Protein-Coupled Receptors as Target Sites for Insecticide Discovery

Bai

Palli

2012

Advanced Technologies for Managing Insect Pests

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“…In all insects examined, genes for AST-A encode several isoforms, e.g., 12-14 in various cockroaches (Donly et al 1993;Belles et al 1999), five in Aedes aegyptii , 10 in Helicoverpa armigera (Davey et al 1999), four in Drosophila melanogaster (Lenz et al 2000), and 14 putative isoforms in Gryllus bimaculatus (Meyering-Vos et al 2001). In Drosophila, two AST receptors (DAR-1 and DAR-2) that most probably have AST-A type peptides as their ligands have recently been described (Birgül et al 1999;Lenz et al 2000;Larsen et al 2001). Similar receptors have been cloned in Bombyx mori and Periplaneta americana (Auerswald et al 2001;Secher et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Development of A-type allatostatin immunoreactivity in antennal lobe neurons of the sphinx moth Manduca sexta

Utz

Schachtner

2005

Cell Tissue Res

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The antennal lobe (AL) of the sphinx moth Manduca sexta is a well-established model system for studying mechanisms of neuronal development. To understand whether neuropeptides are suited to playing a role during AL development, we have studied the cellular localization and temporal expression pattern of neuropeptides of the A-type allatostatin family. Based on morphology and developmental appearance, we distinguished four types of AST-A-immunoreactive cell types. The majority of the cells were local interneurons of the AL (type Ia) which acquired AST-A immunostaining in a complex pattern consisting of three rising (RI-RIII) and two declining phases (DI, DII). Type Ib neurons consisted of two local neurons with large cell bodies not appearing before 7/8 days after pupal ecdysis (P7/P8). Types II and III neurons accounted for single centrifugal neurons, with type II neurons present in the larva and disappearing in the early pupa. The type III neuron did not appear before P7/P8. RI and RII coincided with the rises of the ecdysteroid hemolymph titer. Artificially shifting the pupal 20-hydroxyecdysone (20E) peak to an earlier developmental time point resulted in the precocious appearance of AST-A immunostaining in types Ia, Ib, and III neurons. This result supports the hypothesis that the pupal rise in 20E plays a role in AST-A expression during AL development. Because of their early appearance in newly forming glomeruli, AST-A-immunoreactive fibers could be involved in glomerulus formation. Diffuse AST-A labeling during early AL development is discussed as a possible signal providing information for ingrowing olfactory receptor neurons.

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Type A Allatostatins from Drosophila melanogaster and Diplotera puncata Activate Two Drosophila Allatostatin Receptors, DAR-1 and DAR-2, Expressed in CHO Cells

Cited by 76 publications

References 23 publications

Regulatory peptides in fruit fly midgut

Regulatory peptides in fruit fly midgut

G Protein-Coupled Receptors as Target Sites for Insecticide Discovery

Development of A-type allatostatin immunoreactivity in antennal lobe neurons of the sphinx moth Manduca sexta

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