Type 2 diabetic patients and their offspring show altered parameters of iron status, oxidative stress and genes related to mitochondrial activity

Blanc, Solange Le; Villarroel, Pía; Candia, Valeria; Gavilán, Natalia; Soto, Néstor; Pérez-Bravo, Francisco; Arredondo, Miguel

doi:10.1007/s10534-012-9540-z

Cited by 15 publications

(7 citation statements)

References 46 publications

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“… * A study by Le Blanc et al . 2012 was excluded from the sTfR meta‐analysis as investigated particiants likely overlap with the study by Arredondo et al . 2011 .…”

Section: Resultsmentioning

confidence: 99%

Association of iron indices and type 2 diabetes: a meta‐analysis of observational studies

Orban

Schwab

Thorand

et al. 2014

Diabetes Metabolism Res

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The literature on the role of body iron status in the development of type 2 diabetes (T2D) in humans is inconsistent. We aimed to assess the association between iron indices and T2D by a meta-analysis of previously published studies. A systematic literature search was conducted in PubMed and EMBASE. Observational studies on the association of ferritin (when controlled for age and sex), transferrin saturation, soluble transferrin receptor and transferrin with T2D were included. Pooled association estimates were calculated using a random effects model. Forty-six eligible studies were identified. The pooled multivariable adjusted relative risks of T2D in the highest versus lowest quartile of ferritin levels were significantly elevated in both cross-sectional as well as prospective studies and after restriction to inflammation-adjusted studies [overall: 1.67 (95% CI 1.41-1.99)]. The mean difference indicated 43.54 ng/mL (95% CI 28.14-58.94) higher ferritin levels in type 2 diabetic individuals. The relative risk for a transferrin saturation ≥ 50% was 1.59 (95% CI 1.28-1.97), the mean difference was -1.92% [95% CI -2.99-(-0.85)]. Study-specific results of soluble transferrin receptor and transferrin levels were extremely heterogeneous. Ferritin and clinically elevated transferrin saturation were strongly associated with an increased risk of T2D, overall and in prospective studies. Ferritin was also significantly associated after multivariable adjustment including inflammation. Thus, the current evidence hints at a causal effect; however, publication bias and unmeasured confounding cannot be excluded.

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“… * A study by Le Blanc et al . 2012 was excluded from the sTfR meta‐analysis as investigated particiants likely overlap with the study by Arredondo et al . 2011 .…”

Section: Resultsmentioning

confidence: 99%

Association of iron indices and type 2 diabetes: a meta‐analysis of observational studies

Orban

Schwab

Thorand

et al. 2014

Diabetes Metabolism Res

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“…Several studies have examined sTfR levels in subjects with metabolic syndrome, but their results are quite inconsistent [11, 28–30]. In addition, a meta-analysis of prospective studies demonstrated a negative relationship between transferrin saturation and cardiovascular events such as coronary heart disease and acute myocardial infarction [31].…”

Section: Discussionmentioning

confidence: 99%

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study

Zhu

Xiao

et al. 2019

Lipids Health Dis

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BackgroundInformation on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association between iron metabolism and dyslipidaemia risk.MethodIn total, 1866 children and adolescents aged 7–18 were enrolled in this study, including 912 boys and 954 girls. In this cross-sectional study, parameters for anthropometry, lipids and iron metabolism including transferrin, soluble transferrin receptor (sTfR), ferritin and serum iron (SF) were evaluated. Data regarding demographic characteristics, diet, and physical activity were collected by self-reported questionnaires.ResultsThe prevalence of dyslipidaemia and iron deficiency in children and adolescents increased based on BMI categories (both P < 0.05) and were 58.3 and 8.9% in subjects with obesity, respectively. The lowest SF and the highest ferritin levels were observed in subjects who were obese (both P < 0.001). Subjects with dyslipidaemia had lower SF, transferrin and sTfR levels by different BMI categories, and those who were obese had higher ferritin levels (all P < 0.05). Most importantly, higher concentrations of transferrin and sTfR were related to lower dyslipidaemia risk (OR for transferrin: 0.49, 95% CI: 0.33–0.71; OR for sTfR: 0.68, 95% CI: 0.46–0.99).ConclusionsA downward trend in SF level by BMI categories and the highest ferritin level in subjects with obesity suggested that iron storage was associated with BMI in children and adolescents. Moreover, an inverse relationship was observed between transferrin and sTfR concentrations and dyslipidaemia risk in children with different BMI.

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“…The potential use of DFOB in the treatment of chronic inflammation, such as in diabetes, is also well documented. Some studies reveal an association between the occurrence of iron overload diseases and type-2 diabetes, together with an increased risk of diabetic complications [ 79 , 80 ]. The benefit of iron chelation therapy is likely associated with the improvement of coronary microvasculature function [ 81 ].…”

Section: Dfob In Medicinal Chemistry and Other Applicationsmentioning

confidence: 99%

Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator

Bellotti

Remelli

2021

Molecules

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Deferoxamine B is an outstanding molecule which has been widely studied in the past decade for its ability to bind iron and many other metal ions. The versatility of this metal chelator makes it suitable for a number of medicinal and analytical applications, from the well-known iron chelation therapy to the most recent use in sensor devices. The three bidentate hydroxamic functional groups of deferoxamine B are the centerpiece of its metal binding ability, which allows the formation of stable complexes with many transition, lanthanoid and actinoid metal ions. In addition to the ferric ion, in fact, more than 20 different metal complexes of deferoxamine b have been characterized in terms of their chemical speciation in solution. In addition, the availability of a terminal amino group, most often not involved in complexation, opens the way to deferoxamine B modification and functionalization. This review aims to collect and summarize the available data concerning the complex-formation equilibria in solutions of deferoxamine B with different metal ions. A general overview of the progress of its applications over the past decade is also discussed, including the treatment of iron overload-associated diseases, its clinical use against cancer and neurodegenerative disorders and its role as a diagnostic tool.

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Type 2 diabetic patients and their offspring show altered parameters of iron status, oxidative stress and genes related to mitochondrial activity

Cited by 15 publications

References 46 publications

Association of iron indices and type 2 diabetes: a meta‐analysis of observational studies

Association of iron indices and type 2 diabetes: a meta‐analysis of observational studies

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study

Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator

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