Type 2 diabetes mellitus outcomes after laparoscopic gastric bypass in patients with BMI &lt;35 kg/m2 using strict remission criteria: early outcomes of a prospective study among Mexicans

Espinosa, Omar; Pineda, Omar; Maydón, Hernán; Sepúlveda, Elisa; Guilbert, Laure; Amado, Mónica; Zerrweck, Carlos

doi:10.1007/s00464-017-5815-3

Cited by 9 publications

(1 citation statement)

References 44 publications

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“…Durante la última década, se ha establecido que los factores más importantes para favorecer dicha remisión son los cambios neurohumorales que afectan la regulación de la energía, el apetito, la homeostasis de la glucosa; los cambios inducidos en la microbiota 11 , y los cambios en el metabolismo de los ácidos biliares y sus interacciones con el receptor X farsenoid (FXR) además del cambio en los patrones de dieta y ejercicio.…”

Section: Mecanismos Responsables De La Remisión De Diabetes Mediante ...unclassified

Bipartición de tránsito intestinal, la nueva era de la cirugía metabólica para la diabetes mellitus de tipo 2

Kunz-Martinez

Pérez-Pacheco

2018

rev. colomb. cir.

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Background: Diabetes mellitus type 2 (DM2) is a major public health challenge that we face today; it is the first cause of disability and is associated with the main causes of death in our country. In Mexico City, it was reported that more than 79% of diabetic patients did not have optimal levels of HbA1c (<6.5%), while 47% are not properly controlled (HbA1c> 9%). Metabolic surgery is the best treatment option for DM2, yet the presumed involved mechanisms are not traditionally considered. Objective: To provide an update on the mechanisms involved in the remission of DM2 following metabolic surgery. Methods: Narrative review of the literature, using MeSH terms, until June 1, 2018, encountering 83 articles considered pertinent. Methods: Narrative review of the literature, using MeSH terms, until June 1, 2018, encountering 83 articles considered pertinent. Results: DM2 remission after surgery depends on complex interactions between the microbiota, biliary acids and the intestinal epithelium, more so than of malabsortion or restrictive processes. Bipartition of the intestinal transit constitutes a surgical option based on the physiologic principles responsible of the remission of diabetes, and it is a simple and most secure procedure for the management of diabetes. Mechanisms include restoration/ enhancement of incretin secretion; as well as an improvement of bile acid concentration and microbiome manipulation, rather than the commonly accepted restriction and malabsorption. Intestinal transit bipartition is a novel and simple procedure that complies with the actual involved mechanisms, with comparable results in terms of safety and efficacy with the more complex and demanding techniques, such as the gastric bypass. Conclusions: Metabolic surgery is the best treatment for DM2 in terms of remission and prevention of complications, modifying the secretion of enterohormones, the concentration of biliary acids, and the modification of the microbiota

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Section: Mecanismos Responsables De La Remisión De Diabetes Mediante ...unclassified

Bipartición de tránsito intestinal, la nueva era de la cirugía metabólica para la diabetes mellitus de tipo 2

Kunz-Martinez

Pérez-Pacheco

2018

rev. colomb. cir.

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Metabolic and Bariatric Surgery in Diabetes Management

Valadez¹,

Frigolet

Domínguez³

et al. 2023

The Diabetes Textbook

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Type 2 Diabetes Mellitus Remission Models Following Laparoscopic Gastric Bypass: a 4-Model Analysis in a Latino Population

et al. 2020

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Type 2 diabetes mellitus outcomes after laparoscopic gastric bypass in patients with BMI <35 kg/m2 using strict remission criteria: early outcomes of a prospective study among Mexicans

Abstract: Laparoscopic gastric bypass is a safe and effective method to improve the metabolic profile of mildly obese Mexican patients with type 2 diabetes mellitus, inducing high remission rates even when the strictest model is used.

Cited by 9 publications

References 44 publications

Bipartición de tránsito intestinal, la nueva era de la cirugía metabólica para la diabetes mellitus de tipo 2

Bipartición de tránsito intestinal, la nueva era de la cirugía metabólica para la diabetes mellitus de tipo 2

Metabolic and Bariatric Surgery in Diabetes Management

Type 2 Diabetes Mellitus Remission Models Following Laparoscopic Gastric Bypass: a 4-Model Analysis in a Latino Population

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