Type 2 Diabetes Mellitus, Independent of Insulin Use, is Associated with an Increased Risk of Cardiac Complications after Vascular Surgery

Abstract

Previous reports on the prognostic value of diabetes mellitus for cardiac complications after vascular surgery show divergent results, especially in regards to the role of type 2 diabetes as a cardiac risk factor, which remains unclear. The aim of this study was to assess the impact of type 2 diabetes on 30-day cardiac complications after vascular surgery.Patients undergoing elective vascular surgery between 2002 and 2011 were included in this retrospective cohort study. Previous diagnosis of type 1 and 2 diabetes and use of oral glucose-lowering medications and insulin were recorded. Patients with type 1 diabetes were excluded from the analysis. The main outcome parameter was cardiac complications, a composite of cardiovascular death, non-fatal myocardial infarction, congestive heart failure, severe arrhythmia and asymptomatic troponin release within 30 days of surgery. in multivariate analysis, corrections were made for comorbidities, demographics, medication use and surgical risk.Of 1462 patients, 329 (22.5%) patients had type 2 diabetes. Cardiac complications occurred in 155 (13.7%) patients without diabetes and in 68 (20.7%) with type 2 diabetes. in multivariate analysis, type 2 diabetes was associated with a significantly increased risk of 30-day cardiac complications (odds ratio 1.80; 95% confidence interval 1.25 to 2.60). Results were similar for type 2 diabetes patients managed with (odds ratio 1.84; 95% confidence interval 1.01 to 3.37) and without (odds ratio 1.79; 95% confidence interval 1.19 to 2.70) insulin.Type 2 diabetes is an independent risk factor for cardiac complications after vascular surgery and should be treated as such in preoperative cardiac risk stratification.

Fasting Hyperglycemia Increases In-Hospital Mortality Risk in Nondiabetic Female Patients with Acute Myocardial Infarction: A Retrospective Study

“…In the present study, we defined fasting hyperglycemia in acute myocardial infarction phase to be ≥7.0 mmol/L and admission hyperglycemia to be ≥11.1 mmol/L. This glycaemia cutoff point was convergent with other authors' reports [19]. Moreover, this cutoff point was recommended by worldwide standards for a tool for carbohydrate metabolism disorder diagnosis [20].…”

Major Cardiac Events in Patients Admitted to Intensive Care After Vascular Noncardiac Surgery: A Retrospective Cohort

“…Patients submitted to vascular noncardiac surgery (VS) have several cardiovascular risk factors that are associated with MACE. 3 The risk depends not only on patient or surgical factors but also on intra-or postoperative parameters. 1,3,4 Hemodynamic instability, blood loss, aortic cross clamping, reperfusion phenomena, and arterial embolism may increase the risk of complications after VS. 4 Perioperative myocardial injury is often undetected because it does not exhibit typical symptoms of myocardial ischemia, such as chest pain, angina pectoris, or dyspnea.…”

“…3 The risk depends not only on patient or surgical factors but also on intra-or postoperative parameters. 1,3,4 Hemodynamic instability, blood loss, aortic cross clamping, reperfusion phenomena, and arterial embolism may increase the risk of complications after VS. 4 Perioperative myocardial injury is often undetected because it does not exhibit typical symptoms of myocardial ischemia, such as chest pain, angina pectoris, or dyspnea. 5 Acute myocardial infarction (MI) after major VS may 1 São João Hospital Centre, Porto, Portugal 2 Universidade do Porto, Porto, Portugal range from 0.3% to 36%.…”

Aging and Neuropathy

“…5,40 Yet the contribution of diabetes to perioperative outcomes is likely underreported and underappreciated. 5,40 Yet the contribution of diabetes to perioperative outcomes is likely underreported and underappreciated.…”

“…5,40 Yet the contribution of diabetes to perioperative outcomes is likely underreported and underappreciated. 40 All-cause mortality for diabetics has been reported to be up to 20 times higher than in nondiabetics. [41][42][43] In 1978, Page and Watkins 44 reported 12 cardiac arrests in diabetic patients with autonomic neuropathy.…”