Type 2 diabetes mellitus increases the risk of penile inflammatory disorders in men aged between 30 and 49: a 5-year follow-up study

Wang, Chung‐Cheng; Wang, Ivy; Lai, Yi-Horng

doi:10.1007/s13410-022-01081-4

Cited by 1 publication

(3 citation statements)

References 22 publications

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“…However, the study disclosed that only DM, but not hypertension or hyperlipidemia, was a risk factor for circumcision in adult males. The findings from the study echoed those from a large epidemiological survey that revealed that type 2 DM, but not hypertension or hyperlipidemia, was associated with an increased risk of penile inflammatory diseases in men between 30 and 49 years of age [ 10 ]. Since compared to non-DM controls, only DM patients had more cases of balanoposthitis, we presumed that the medical need for circumcision would increase among DM patients.…”

Section: Discussionsupporting

confidence: 60%

“…This study demonstrated that T2DM, but not hypertension or hyperlipidemia, was associated with adult circumcision. A previous large longitudinal cohort study revealed that penile inflammatory disorders were more common among males with T2DM [ 6 , 10 ]. In addition, recurrent balanoposthitis and balanitis xerotica obliterans (BXO) are considered surgical indications for circumcision [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…A total of 191,601 out of 1 million patients qualified for this study, and 23,197 male patients with newly diagnosed DM between 1998 and 2005 were identified. We decided the time scale of 5 years based on our previous study which showed type 2 DM increased the risk of penile inflammatory disorders in men in a 5-year follow-up study [ 10 ]. Among the 23,197 patients with type 2 DM during the follow-up period that ended in December 2010, sixty-nine patients underwent circumcision.…”

Section: Methodsmentioning

confidence: 99%

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Type 2 diabetes mellitus increases the risk of circumcision among men aged between 30 and 69 years using a nationwide population-based dataset in Taiwan: a five-year follow-up study

Wu,

Lai,

Wang

2024

BMC Urol

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Background Diabetes is an important factor in the development of penile inflammation. We studied whether type 2 diabetes (DM), with/without hypertension and hyperlipidemia increased the risk of circumcision among men aged between 30 and 69 using a population-based dataset in Taiwan during a 5-year follow-up period. Methods The research data in this study were obtained from Taiwan’s National Health Insurance Research Database between 1997 and 2010. We identified 23,197 patients who had a new diagnosis of DM and randomly matched 115,985 subjects as controls. We observed whether circumcision was the treatment after a new DM diagnosis. The initial step involved analyzing the data using Poisson regression analysis. To address potential confounding factors, this study employed propensity score matching based on three variables. Additionally, a Cox regression with a Gamma frailty was utilized to compare outcomes between different groups. Results Poisson regression analysis showed that DM (RR = 1.75, 95CI = 0.10 ~ 1.22), but not hypertension (RR = 1.14, 95CI=-0.44 ~ 0.70), hyperlipidemia (RR = 0.94, 95CI=-0.66 ~ 0.53), or age (RR = 0.83, 95CI=-0.43 ~ 0.62), had an impact on circumcision treatment. Cox regression with a frailty model found that DM was a risk factor associated with circumcision (HR = 2.31, 95% CI = 1.74 ~ 3.06, p-value < 0.01), whereas no significant difference was noted between circumcision and hypertension (HR = 1.10, 95% CI = 0.80 ~ 1.51), hyperlipidemia (HR = 1.05, 95% CI = 0.79 ~ 1.40), or age (HR = 1.00, 95% CI = 0.99 ~ 1.02). Conclusions Type 2 diabetes mellitus, but not hypertension, hyperlipidemia or age increases the risk of circumcision in men aged between 30 and 69 years.

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Section: Discussionsupporting

confidence: 60%